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Molecules
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Application of Paper-Based Analytical Devices
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Application of Paper-Based Analytical Devices

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (31 July 2019) | Viewed by 26378

Special Issue Editor

Prof. Dr. Sungsu Park

E-Mail Website
Guest Editor
School of Mechanical Engineering, Sungkyunkwan University, Suwon, Republic of Korea
Interests: microfluidic chip; detection; automated system; spheroid; cancer drug resistance; stretching device; paper-based analytical device

Special Issue Information

Dear Colleagues,

There is a growing need for low-cost technologies that can easily detect and monitor diseases and environmental contaminants in the field. Thus, microfluidic paper-based analyzers (μPAD) have attracted much attention because they are cheap, easy to use, and do not require external power. Recently, Martinez et al. reported the first μPAD for multiplexed chemical analysis. Even more recently, Park et al. reported a 3D printing method to improve the signal uniformity and sensitivity of the mPADs.

In this context, it is my pleasure to invite you to submit an article for a Special Issue dedicated to the subject of “2D- and 3D-microfluidic paper-based analytical devices (µPADs)”. All previously unpublished manuscripts covering all topics, including applications, fabrication, multiplex analysis, theoretical studies of flow in uPADs are welcome, as well as reviews and mini-review articles. I do hope that you accept this invitation and join in the continuing success of this area of expertise.

Prof. Dr. Sungsu Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • 2D-uPADs
  • 3D-uPADs
  • simulation
  • fabrication
  • multiplex analysis
  • transport
  • environmental monitoring
  • POCTs

Published Papers (3 papers)

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Research

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10 pages, 2449 KiB  
Article
Magnetized Carbon Nanotube Based Lateral Flow Immunoassay for Visual Detection of Complement Factor B
by Yan Huang, Tingting Wu, Fang Wang, Kun Li, Lisheng Qian, Xueji Zhang and Guodong Liu
Molecules 2019, 24(15), 2759; https://doi.org/10.3390/molecules24152759 - 30 Jul 2019
Cited by 10 | Viewed by 4202
Abstract
The authors describe a magnetized carbon nanotube (MCNT) based lateral flow immunoassay (LFI) for visual detection of complement factor B (CFB) in blood. MCNT was prepared by decorating magnetic Fe3O4 nanoparticles on multi-walled CNT surface and used as a colored [...] Read more.
The authors describe a magnetized carbon nanotube (MCNT) based lateral flow immunoassay (LFI) for visual detection of complement factor B (CFB) in blood. MCNT was prepared by decorating magnetic Fe3O4 nanoparticles on multi-walled CNT surface and used as a colored tag for LFI. Monoclonal antibody (mAb, Ab1) of CFB was covalently immobilized on the MCNT surface via diimide-activated conjugation between the carboxyl groups on the MCNT surface and amino groups of antibodies. Polyclonal antibody of CFB (Ab2) and the secondary antibody were used to prepare the lateral flow test strips. The assay involved: (1) the capture of CFB in blood with the mAb-functionalized MCNT; (2) magnetic separation of the formed CFB-mAb-MCNT and excess of mAb-MCNT from the blood with an external magnet; (3) lateral flow test to capture the CFB-mAb-MCNT complex on the test zone and the excess of mAb-MCNT on the control zone; (4) Recording the intensities of the produced the characteristic brown bands with a portable strip reader and quantitating the concentration of CFB. The proof-of-concept was demonstrated by testing CFB in the buffer, and the detection limit was 5 ng mL−1 under the optimized analytical parameters. CFB in 1 μL of human blood was detected successfully in 30 min with this LFI and the results had a high correlation with commercial ELISA kit. Thence, the MCNT-based LFI offers a rapid and low-cost tool for detecting CFB in human blood directly. Full article
(This article belongs to the Special Issue Application of Paper-Based Analytical Devices)
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Review

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32 pages, 4775 KiB  
Review
Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices
by Hosub Lim, Ali Turab Jafry and Jinkee Lee
Molecules 2019, 24(16), 2869; https://doi.org/10.3390/molecules24162869 - 7 Aug 2019
Cited by 111 | Viewed by 13366
Abstract
Paper-based microfluidic devices have advanced significantly in recent years as they are affordable, automated with capillary action, portable, and biodegradable diagnostic platforms for a variety of health, environmental, and food quality applications. In terms of commercialization, however, paper-based microfluidics still have to overcome [...] Read more.
Paper-based microfluidic devices have advanced significantly in recent years as they are affordable, automated with capillary action, portable, and biodegradable diagnostic platforms for a variety of health, environmental, and food quality applications. In terms of commercialization, however, paper-based microfluidics still have to overcome significant challenges to become an authentic point-of-care testing format with the advanced capabilities of analyte purification, multiplex analysis, quantification, and detection with high sensitivity and selectivity. Moreover, fluid flow manipulation for multistep integration, which involves valving and flow velocity control, is also a critical parameter to achieve high-performance devices. Considering these limitations, the aim of this review is to (i) comprehensively analyze the fabrication techniques of microfluidic paper-based analytical devices, (ii) provide a theoretical background and various methods for fluid flow manipulation, and (iii) highlight the recent detection techniques developed for various applications, including their advantages and disadvantages. Full article
(This article belongs to the Special Issue Application of Paper-Based Analytical Devices)
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22 pages, 11839 KiB  
Review
Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations
by Yi Zhao, Ranjith Kumar Kankala, Shi-Bin Wang and Ai-Zheng Chen
Molecules 2019, 24(4), 675; https://doi.org/10.3390/molecules24040675 - 14 Feb 2019
Cited by 85 | Viewed by 8365
Abstract
With advantageous features such as minimizing the cost, time, and sample size requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from researchers for their ability for real-time monitoring of physical parameters by mimicking the in vivo microenvironment and the precise responses of xenobiotics, [...] Read more.
With advantageous features such as minimizing the cost, time, and sample size requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from researchers for their ability for real-time monitoring of physical parameters by mimicking the in vivo microenvironment and the precise responses of xenobiotics, i.e., drug efficacy and toxicity over conventional two-dimensional (2D) and three-dimensional (3D) cell cultures, as well as animal models. Recent advancements of OOC systems have evidenced the fabrication of ‘multi-organ-on-chip’ (MOC) models, which connect separated organ chambers together to resemble an ideal pharmacokinetic and pharmacodynamic (PK-PD) model for monitoring the complex interactions between multiple organs and the resultant dynamic responses of multiple organs to pharmaceutical compounds. Numerous varieties of MOC systems have been proposed, mainly focusing on the construction of these multi-organ models, while there are only few studies on how to realize continual, automated, and stable testing, which still remains a significant challenge in the development process of MOCs. Herein, this review emphasizes the recent advancements in realizing long-term testing of MOCs to promote their capability for real-time monitoring of multi-organ interactions and chronic cellular reactions more accurately and steadily over the available chip models. Efforts in this field are still ongoing for better performance in the assessment of preclinical attributes for a new chemical entity. Further, we give a brief overview on the various biomedical applications of long-term testing in MOCs, including several proposed applications and their potential utilization in the future. Finally, we summarize with perspectives. Full article
(This article belongs to the Special Issue Application of Paper-Based Analytical Devices)
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