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Special Issue "Application of Paper-Based Analytical Devices"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 31 July 2019

Special Issue Editor

Guest Editor
Prof. Dr. Sungsu Park

School of Mechanical Engineering, Sungkyunkwan University, Suwon, Korea
Website | E-Mail
Interests: microfluidic chip; detection; automated system; spheroid; cancer drug resistance; stretching device; paper-based analytical device

Special Issue Information

Dear Colleagues,

There is a growing need for low-cost technologies that can easily detect and monitor diseases and environmental contaminants in the field. Thus, microfluidic paper-based analyzers (μPAD) have attracted much attention because they are cheap, easy to use, and do not require external power. Recently, Martinez et al. reported the first μPAD for multiplexed chemical analysis. Even more recently, Park et al. reported a 3D printing method to improve the signal uniformity and sensitivity of the mPADs.

In this context, it is my pleasure to invite you to submit an article for a Special Issue dedicated to the subject of “2D- and 3D-microfluidic paper-based analytical devices (µPADs)”. All previously unpublished manuscripts covering all topics, including applications, fabrication, multiplex analysis, theoretical studies of flow in uPADs are welcome, as well as reviews and mini-review articles. I do hope that you accept this invitation and join in the continuing success of this area of expertise.

Prof. Dr. Sungsu Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • 2D-uPADs
  • 3D-uPADs
  • simulation
  • fabrication
  • multiplex analysis
  • transport
  • environmental monitoring
  • POCTs

Published Papers (1 paper)

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Review

Open AccessReview
Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations
Molecules 2019, 24(4), 675; https://doi.org/10.3390/molecules24040675
Received: 8 January 2019 / Revised: 6 February 2019 / Accepted: 11 February 2019 / Published: 14 February 2019
PDF Full-text (11839 KB) | HTML Full-text | XML Full-text
Abstract
With advantageous features such as minimizing the cost, time, and sample size requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from researchers for their ability for real-time monitoring of physical parameters by mimicking the in vivo microenvironment and the precise responses of xenobiotics, [...] Read more.
With advantageous features such as minimizing the cost, time, and sample size requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from researchers for their ability for real-time monitoring of physical parameters by mimicking the in vivo microenvironment and the precise responses of xenobiotics, i.e., drug efficacy and toxicity over conventional two-dimensional (2D) and three-dimensional (3D) cell cultures, as well as animal models. Recent advancements of OOC systems have evidenced the fabrication of ‘multi-organ-on-chip’ (MOC) models, which connect separated organ chambers together to resemble an ideal pharmacokinetic and pharmacodynamic (PK-PD) model for monitoring the complex interactions between multiple organs and the resultant dynamic responses of multiple organs to pharmaceutical compounds. Numerous varieties of MOC systems have been proposed, mainly focusing on the construction of these multi-organ models, while there are only few studies on how to realize continual, automated, and stable testing, which still remains a significant challenge in the development process of MOCs. Herein, this review emphasizes the recent advancements in realizing long-term testing of MOCs to promote their capability for real-time monitoring of multi-organ interactions and chronic cellular reactions more accurately and steadily over the available chip models. Efforts in this field are still ongoing for better performance in the assessment of preclinical attributes for a new chemical entity. Further, we give a brief overview on the various biomedical applications of long-term testing in MOCs, including several proposed applications and their potential utilization in the future. Finally, we summarize with perspectives. Full article
(This article belongs to the Special Issue Application of Paper-Based Analytical Devices)
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