Medicinal Chemistry Studies of Neglected Diseases

Dear Colleagues,

The reemergence of neglected tropical diseases, in particular in Subsaharian Africa due to unique resistance mechanisms of parasites, provides a challenge for medicinal chemistry in the future. Novel compounds containing new scaffolds might offer one way to tackle the problem. Secondly, specificity of parasitic target inhibition is necessary, in particular when a paralogue of the target is present in the human host. Thus, the introduction of chemical modifications into a scaffold might be of interest for lead optimization. Thirdly, rapid and robust analytical assays are necessary to predict the efficacy of a small molecule. Currently, the available big data for drug targets will facilitate the design of specific inhibitors on the basis of medicinal chemistry. Preclinical studies presenting in vitro or in vivo technologies are of further interest. Please, feel free to contact Lucy Chai (lucy.chai@mdpi.com) if you would like to contribute to this special issue.

Prof. Dr. Annette Kaiser
Guest Editor

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