Cinnamic Acids Hybrids with Biological Interest

Dear Colleagues,

Cinnamic acid derivatives from natural and synthetic sources have attracted much attention due to their significant biological activities (e.g., antioxidant, antitumor, antimicrobial activities). Recently, intensive research has been conducted on cinnamic acid hybrids, with the goal of creating new polyfunctional drugs based on them. Piplartin, an alkaloid and a trans-cinnamic acid derivative, which is isolated from Piper tuberculatum, has been shown to have antitumor and antiproliferative properties. A whole series of drugs has been created on the basis of cinnamic acid presenting antiallergic activity (e.g., Cinnarizine, Cinanserin, Tranilast).

Molecular hybridization consists of a molecular modification approach to obtain multifunctional ligands and drugs with better pharmacokinetic properties and the concomitant administration of two different agents. The design principle is aimed at combining the synergistic property of cinnamic acid with the sequestering activity of other biologically active chemical entities or molecules, so as to get compounds with better activities.

In this issue, we will present a number of several cinnamic hybrids, their syntheses, and biological evaluation, as well as reviews in related subjects.

Prof. D. Hadjipavlou-Litina
Guest Editor

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