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Molecules 2014, 19(12), 19292-19349;

Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity

Departamento de Química y Biología, División de Ciencias Básicas, Universidad del Norte, Km. 5 vía Puerto Colombia, Barranquilla 081007, Colombia
Received: 20 October 2014 / Revised: 14 November 2014 / Accepted: 18 November 2014 / Published: 25 November 2014
(This article belongs to the Special Issue Cinnamic Acids Hybrids with Biological Interest)
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Antimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides, aldehydes and alcohols, show significant growth inhibition against one or several bacterial and fungal species. Of particular interest is the potent antitubercular activity observed for some of these cinnamic derivatives, which may be amenable as future drugs for treating tuberculosis. This review intends to summarize the literature data on the antimicrobial activity of the natural cinnamic acids and related derivatives. In addition, selected hybrids between cinnamic acids and biologically active scaffolds with antimicrobial activity were also included. A comprehensive literature search was performed collating the minimum inhibitory concentration (MIC) of each cinnamic acid or derivative against the reported microorganisms. The MIC data allows the relative comparison between series of molecules and the derivation of structure-activity relationships. View Full-Text
Keywords: cinnamic acid; coumaric acids; hybrids; antimicrobial; tuberculosis cinnamic acid; coumaric acids; hybrids; antimicrobial; tuberculosis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Guzman, J.D. Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity. Molecules 2014, 19, 19292-19349.

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