Synthesis and Pharmacochemistry of New Pleiotropic Pyrrolyl Derivatives
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (1 December 2019) | Viewed by 4327
Special Issue Editor
Interests: synthesis and biological studies on anti-inflammatory and antioxidant agents, on inhibitors of enzymes implicated in the inflammation and in the coagulation process in general; correlation of inflammation with cancer; neurodegeneration; antioxidant activity; theoretical and experimental calculation of physicochemical parameters implicated in biological response; use of computational chemistry in drug design as well as bioactive compounds of natural origin, e.g., essential oils
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nowadays, there is great interest in the use of pleiotropic/multifunctional/multitarget drugs for the treatment of complex diseases, in which more than one target is implicated. Multifactorial disorders like inflammation, cancer, and Alzheimer’s disease can be characterised as complex diseases. Inflammation is the natural response of the biological system to various stimuli. Excessive chronic inflammation is linked to reactive oxygen species and oxidative stress and leads to pathological disorders, such as atherosclerosis, rheumatoid arthritis, neurogenerative diseases and various types of cancer. Thus, molecules acting against several biological targets implicated in inflammation presenting anti-inflammatory and/or, antioxidant and/or anticoagulant activities will be useful.
Pyrrole is a privileged chemical scaffold correlated with interesting bioactivities. The pyrrole ring is an imperative structural framework found in a variety of biologically-active natural products and pharmaceutically-active molecules. The ability to form chelate complexes with metals explains the significance of pyrrole derivatives in biological systems. Pyrrolyl derivatives are referred to act as effective pleiotropic bioactive agents and for this reason there is great interest in these substances within medicinal chemistry.
Prof. Dr. Dimitra Hadjipavlou-Litina
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pyrrole derivatives
- hybrids
- multifunctional/pleiotropic/multitarget agents
- synthesis
- quantitative structure/activity relationships QSAR
- modelling
- drug design
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
