Synthesis and Pharmacochemistry of New Pleiotropic Pyrrolyl Derivatives

Dear Colleagues,

Nowadays, there is great interest in the use of pleiotropic/multifunctional/multitarget drugs for the treatment of complex diseases, in which more than one target is implicated. Multifactorial disorders like inflammation, cancer, and Alzheimer’s disease can be characterised as complex diseases. Inflammation is the natural response of the biological system to various stimuli. Excessive chronic inflammation is linked to reactive oxygen species and oxidative stress and leads to pathological disorders, such as atherosclerosis, rheumatoid arthritis, neurogenerative diseases and various types of cancer. Thus, molecules acting against several biological targets implicated in inflammation presenting anti-inflammatory and/or, antioxidant and/or anticoagulant activities will be useful.

Pyrrole is a privileged chemical scaffold correlated with interesting bioactivities. The pyrrole ring is an imperative structural framework found in a variety of biologically-active natural products and pharmaceutically-active molecules. The ability to form chelate complexes with metals explains the significance of pyrrole derivatives in biological systems. Pyrrolyl derivatives are referred to act as effective pleiotropic bioactive agents and for this reason there is great interest in these substances within medicinal chemistry.

Prof. Dr. Dimitra Hadjipavlou-Litina
Guest Editor

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