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Terpenes and Their Derivatives: From Nature to Medical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 925

Special Issue Editors


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Guest Editor
College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China
Interests: marine natural products; marine invertebrates; structure elucidation; anti-diabetic bioactivity; terpene biosynthesis
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Guest Editor
Drug Discovery Informatics Laboratory, Qasemi Research Center, Al-Qasemi Academic College, P.O. Box 124, Baqa El-Gharbia 30100, Israel
Interests: natural products; antibacterial activity; antidiabetic activity; anticancer activity; anti-inflammatory activity; drug discovery informatics; QSAR
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Guest Editor
Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Interests: antioxidants; bioactive compounds; small molecules; polyphenols; antibacterial activity; anticancer activity; medicinal chemistry; synthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Terpenes are an important and abundant group of natural products. They can be extracted and isolated from many natural sources, including terrestrial plants, mangroves, marine algae, insects, marine invertebrates, bacterial, fungi, and others. They display various structural features, which can be grouped as monoterpenes, sesquiterpenes, diterpenes, sesterterpenes, triterpenes, tetraterpenes, and others. Some terpenes are dimeric, trimeric, and even tetrameric. These structures are established by extensive spectral data, and in some cases, chemical modifications and synthesis are used to assist the structure elucidation. Moreover, chemical synthesis and biosynthesis are performed to produce large quantities or novel types of terpenes. Notably, terpenes show multiple pharmaceutical effects, such as anti-diabetes, anti-inflammatory, anti-microbial, anti-tumor, and antioxidant activity, and some are clinically used, such as paclitaxel and artemisinin.

The aim of this Special Issue is to cover all the aspects of the chemistry and biology of these promising molecules, comprising their extraction and isolation, structure elucidation, chemosynthetic and biosynthetic studies, metabolomic properties, semisynthetic transformations and total synthesis, pharmaceutical effects, and mechanisms of action.

As Guest Editors of this Special Issue, we encourage researchers to help develop the field of terpenes via contributions including research articles, reviews, and other types of works.

Dr. Linfu Liang
Dr. Anwar Rayan
Dr. Barbara De Filippis
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • terpenes
  • plants
  • animals
  • microbes
  • extraction technologies
  • structure elucidation
  • chemical synthesis and biosynthesis
  • biological investigation

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Published Papers (2 papers)

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Research

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14 pages, 3698 KB  
Article
Natural Tyrosinase Inhibitors from Lycopodium japonicum
by Zeng-Yue Ge, Ya-Qing Wang, Qi-Bin Yang, Xian-Yun Yan, Lei Wu, Min Zhang and Lin-Fu Liang
Molecules 2025, 30(19), 4024; https://doi.org/10.3390/molecules30194024 - 9 Oct 2025
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Abstract
Natural tyrosinase inhibitors are an important group of compounds with cosmetical and medicinal applications. With the aim of finding new types of natural tyrosinase inhibitors from ornamental and medicinal plants, Lycopodium japonicum was selected and studied. As a result, fifteen structurally diverse secondary [...] Read more.
Natural tyrosinase inhibitors are an important group of compounds with cosmetical and medicinal applications. With the aim of finding new types of natural tyrosinase inhibitors from ornamental and medicinal plants, Lycopodium japonicum was selected and studied. As a result, fifteen structurally diverse secondary metabolites 115 were isolated and identified. Their chemical structures were identified by analysis of their spectral data and compared with those reported in the literature. In the tyrosinase inhibitory bioassay, five phytochemicals, 4, 12, 13, 14, and 15, exhibited significant inhibitory effects, with half-maximal inhibitory concentration (IC50) values ranging from 1.46 to 6.82 mM. Additionally, molecular docking studies disclosed that Lys376, Lys379, Gln307, and other amino acid residues played key roles in the potential binding interactions between the active compounds and the tyrosinase. These findings suggest that the species L. japonicum is a warehouse of natural tyrosinase inhibitors. Full article
(This article belongs to the Special Issue Terpenes and Their Derivatives: From Nature to Medical Applications)
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Review

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45 pages, 4749 KB  
Review
Molecular Diversity of Lupane Hybrids in Drug Design and Materials Science
by Victoria V. Lipson, Maria G. Shirobokova, Mustafa Kemal Gümüş, Arda Ozturkcan and Valentyn A. Chebanov
Molecules 2025, 30(20), 4108; https://doi.org/10.3390/molecules30204108 - 16 Oct 2025
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Abstract
The need for new, more effective drugs to treat cancer, infectious diseases, various parasitic infestations, and metabolic disorders requires innovative approaches to the design of promising molecules. One of these areas is the creation of hybrid structures. Lupane triterpenoids are of significant interest [...] Read more.
The need for new, more effective drugs to treat cancer, infectious diseases, various parasitic infestations, and metabolic disorders requires innovative approaches to the design of promising molecules. One of these areas is the creation of hybrid structures. Lupane triterpenoids are of significant interest for such research due to their high abundance in natural sources and their renewable nature, their molecular architecture, presence of several easily modifiable functional groups, enantiomeric purity, broad spectrum of biological activity, and low toxicity. Active research into the biological properties of new pentacyclic triterpenoid derivatives, not only of the lupane series but also of the oleonane and ursane series, is evidenced by the large number of reviews and experimental studies devoted to this topic. Our interest in the modification of lupanoids stems not only from the search for biologically active compounds but also from the development of functional materials. However, the materials science aspects of lupanoid applications are virtually unknown in literature. We have tried to fill this gap and examined the possibility of using betulin derivatives to create advanced materials. The high lipophilicity and nanoscale molecular structure of these compounds make them highly promising as chiral dopants in liquid crystal compositions and organogel components. Full article
(This article belongs to the Special Issue Terpenes and Their Derivatives: From Nature to Medical Applications)
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