molecules-logo

Journal Browser

Journal Browser

Characterization, and Protective Effects on Metabolic Syndrome of Functional Components in Food

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 3927

Special Issue Editors

Institute for Advanced Study, Shenzhen University, No. 3688 Nanhai Avenue, Shenzhen 518060, China
Interests: food chemistry and toxicology; chronic disease prevention; food additives; instrumental analysis; natural products

E-Mail Website
Guest Editor
Department of Technique and Food Development, Institute of Human Nutrition Sciences, Nowoursynowska 159c Street, 02-776 Warsaw, Poland
Interests: microencapsulation of bioactive compounds; processing of food products of plant origin and their compounds (vegetables, fruits, and cereals); experimental design in food technology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic syndrome, also known as syndrome X, is a cluster of pathological conditions that occur together, increasing the risk of obesity, heart disease, stroke, type 2 diabetes, and other disabilities. These conditions include abnormal fat around the waist, hyperlipidemia, hypertension, and insulin resistance. The basic force spreading this syndrome can be attributed to the modern lifestyle, which is characterized by increased consumption of fast food and decreased physical activity. Additionally, the global epidemic of metabolic syndrome has laid a heavy burden on families and governments, causing a loss of economic activity in the trillions. Because of that, there have been increased efforts in the prevention and management of this malady. It is worth noting that recent research has exemplified the critical role of functional food components (e.g., polyphenols, polysaccharides, and peptides) in metabolic syndrome. However, there are still some research gaps in this field that need to be unraveled.

The Special Issue of “Characterization, and Protective Effects on Metabolic Syndrome of Functional Components in Food” welcomes cutting-edge research and review articles to address these issues:

  1.  Identify novel functional foods with potential for metabolic syndrome;
  2.  Characterize the active components by traditional methods or by high-throughput sequencing;
  3.  Unravel the underlying mechanism and make clear the target gene/signaling pathway;
  4.  Understand the structural activity relationship to offer prospective information for future studies.

Dr. Qian Zhou
Dr. Marcin A. Kurek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic syndrome
  • functional food
  • obesity
  • type 2 diabetes
  • polyphenols
  • polysaccharides
  • bioactive peptides

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 3928 KiB  
Article
Biodirected Screening and Preparation of Larimichthys crocea Angiotensin-I-Converting Enzyme-Inhibitory Peptides by a Combined In Vitro and In Silico Approach
by Zhizhi Yang, Changrong Wang, Baote Huang, Yihui Chen, Zhiyu Liu, Hongbin Chen and Jicheng Chen
Molecules 2024, 29(5), 1134; https://doi.org/10.3390/molecules29051134 - 3 Mar 2024
Cited by 4 | Viewed by 1505
Abstract
Food-derived angiotensin-I-converting enzyme (ACE)-inhibitory peptides have gained attention for their potent and safe treatment of hypertensive disorders. However, there are some limitations of conventional methods for preparing ACE-inhibitory peptides. In this study, in silico hydrolysis, the quantitative structure–activity relationship (QSAR) model, LC-MS/MS, inhibition [...] Read more.
Food-derived angiotensin-I-converting enzyme (ACE)-inhibitory peptides have gained attention for their potent and safe treatment of hypertensive disorders. However, there are some limitations of conventional methods for preparing ACE-inhibitory peptides. In this study, in silico hydrolysis, the quantitative structure–activity relationship (QSAR) model, LC-MS/MS, inhibition kinetics, and molecular docking were used to investigate the stability, hydrolyzability, in vitro activity, and inhibition mechanism of bioactive peptides during the actual hydrolysis process. Six novel ACE-inhibitory peptides were screened from the Larimichthys crocea protein (LCP) and had low IC50 values (from 0.63 ± 0.09 µM to 10.26 ± 0.21 µM), which were close to the results of the QSAR model. After in vitro gastrointestinal simulated digestion activity of IPYADFK, FYEPFM and NWPWMK were found to remain almost unchanged, whereas LYDHLGK, INEMLDTK, and IHFGTTGK were affected by gastrointestinal digestion. Meanwhile, the inhibition kinetics and molecular docking results were consistent in that ACE-inhibitory peptides of different inhibition forms could effectively bind to the active or non-central active centers of ACE through hydrogen bonding. Our proposed method has better reproducibility, accuracy, and higher directivity than previous methods. This study can provide new approaches for the deep processing, identification, and preparation of Larimichthys crocea. Full article
Show Figures

Graphical abstract

Review

Jump to: Research

24 pages, 2501 KiB  
Review
Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo Studies
by Matthew Terzo, Michael Iantomasi and Evangelia Tsiani
Molecules 2024, 29(22), 5359; https://doi.org/10.3390/molecules29225359 - 14 Nov 2024
Cited by 3 | Viewed by 1687
Abstract
Obesity, a prevalent global health issue, arises from an imbalance between caloric intake and energy expenditure, leading to the expansion of adipose tissue and metabolic dysfunction. White adipose tissue (WAT) stores energy as lipids, while brown adipose tissue (BAT) plays a pivotal role [...] Read more.
Obesity, a prevalent global health issue, arises from an imbalance between caloric intake and energy expenditure, leading to the expansion of adipose tissue and metabolic dysfunction. White adipose tissue (WAT) stores energy as lipids, while brown adipose tissue (BAT) plays a pivotal role in energy dissipation through adaptive thermogenesis. Recent research initiatives have focused on finding strategies to decrease adipogenesis and fat mass accumulation and increase thermogenesis. Finding chemicals with anti-obesity properties would be beneficial. Resveratrol, a polyphenolic compound abundantly found in the skin of grapes and red wine, possesses anti-oxidant, anti-inflammatory, anti-cancer, and anti-obesity properties. This literature review examines the effects of resveratrol on adipocytes in culture and adipose tissue in animal models of obesity. The existing evidence indicates that resveratrol may exert its anti-obesity effects by inhibiting adipogenesis, promoting the apoptosis of mature adipocytes, reducing lipid accumulation, and increasing thermogenesis. Further research utilizing animal and clinical studies is required to understand in detail the anti-obesity potential of resveratrol. Full article
Show Figures

Figure 1

Back to TopTop