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Advanced Synthetic Strategies in Nanomedicine and Its Impact on Biological and Medical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 8000

Special Issue Editors


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Guest Editor
Department of Molecular Medicine, Princess Al-Jawhara Centre for Molecular Medicine, School of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain
Interests: tumor biology; EPR effect; anticancer nanomedicine; nanotoxicology; micelles

Special Issue Information

Dear Colleagues,

Nanomedicine is an adaptive tool accommodating a rich background for scientific research and technological development, with the field expanding to areas such as novel approaches for cancer treatment, immunotherapy, vaccine development, gene delivery, and theranostic tools, to name a few.

The scope of the present Special Issue is to gain more insight into the versatile and adaptive nature of nanomedicine in biology and medical applications.

In this context, I invite researchers to submit their original communications, perspectives, and research and review articles on novel applications of nanomedicine, theranostic applications, solid-state nanoparticles, vaccine development, immunotherapy, tissue engineering, and cancer therapeutics.

Prof. Dr. Greish Khaled
Dr. Jun Fang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • novel applications of nanomedicine
  • theranostic applications
  • solid-state nanoparticles
  • vaccine development
  • immunotherapy
  • gene delivery
  • tissue engineering
  • cancer therapeutics

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Published Papers (2 papers)

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Review

22 pages, 2535 KiB  
Review
Self-Assembled Ferritin Nanoparticles for Delivery of Antigens and Development of Vaccines: From Structure and Property to Applications
by Shinuo Cao, Dongxue Ma, Shengwei Ji, Mo Zhou and Shanyuan Zhu
Molecules 2024, 29(17), 4221; https://doi.org/10.3390/molecules29174221 - 5 Sep 2024
Cited by 1 | Viewed by 2033
Abstract
Ferritin, an iron storage protein, is ubiquitously distributed across diverse life forms, fulfilling crucial roles encompassing iron retention, conversion, orchestration of cellular iron metabolism, and safeguarding cells against oxidative harm. Noteworthy attributes of ferritin include its innate amenability to facile modification, scalable mass [...] Read more.
Ferritin, an iron storage protein, is ubiquitously distributed across diverse life forms, fulfilling crucial roles encompassing iron retention, conversion, orchestration of cellular iron metabolism, and safeguarding cells against oxidative harm. Noteworthy attributes of ferritin include its innate amenability to facile modification, scalable mass production, as well as exceptional stability and safety. In addition, ferritin boasts unique physicochemical properties, including pH responsiveness, resilience to elevated temperatures, and resistance to a myriad of denaturing agents. Therefore, ferritin serves as the substrate for creating nanomaterials typified by uniform particle dimensions and exceptional biocompatibility. Comprising 24 subunits, each ferritin nanocage demonstrates self-assembly capabilities, culminating in the formation of nanostructures akin to intricate cages. Recent years have witnessed the ascendance of ferritin-based self-assembled nanoparticles, owing to their distinctive physicochemical traits, which confer substantial advantages and wide-ranging applications within the biomedical domain. Ferritin is highly appealing as a carrier for delivering drug molecules and antigen proteins due to its distinctive structural and biochemical properties. This review aims to highlight recent advances in the use of self-assembled ferritin as a novel carrier for antigen delivery and vaccine development, discussing the molecular mechanisms underlying its action, and presenting it as a promising and effective strategy for the future of vaccine development. Full article
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28 pages, 1327 KiB  
Review
Therapeutic Applications of Nanomedicine: Recent Developments and Future Perspectives
by Farah Rehan, Mingjie Zhang, Jun Fang and Khaled Greish
Molecules 2024, 29(9), 2073; https://doi.org/10.3390/molecules29092073 - 30 Apr 2024
Cited by 5 | Viewed by 5370
Abstract
The concept of nanomedicine has evolved significantly in recent decades, leveraging the unique phenomenon known as the enhanced permeability and retention (EPR) effect. This has facilitated major advancements in targeted drug delivery, imaging, and individualized therapy through the integration of nanotechnology principles into [...] Read more.
The concept of nanomedicine has evolved significantly in recent decades, leveraging the unique phenomenon known as the enhanced permeability and retention (EPR) effect. This has facilitated major advancements in targeted drug delivery, imaging, and individualized therapy through the integration of nanotechnology principles into medicine. Numerous nanomedicines have been developed and applied for disease treatment, with a particular focus on cancer therapy. Recently, nanomedicine has been utilized in various advanced fields, including diagnosis, vaccines, immunotherapy, gene delivery, and tissue engineering. Multifunctional nanomedicines facilitate concurrent medication delivery, therapeutic monitoring, and imaging, allowing for immediate responses and personalized treatment plans. This review concerns the major advancement of nanomaterials and their potential applications in the biological and medical fields. Along with this, we also mention the various clinical translations of nanomedicine and the major challenges that nanomedicine is currently facing to overcome the clinical translation barrier. Full article
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