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Open AccessArticle

Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans

1
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, D-69120 Heidelberg, Germany
2
Metabolomics and Mass Spectrometry Research Group, Amazonas State University (UEA), Manaus 690065-130, Brazil
3
Department of Chemistry, Federal University of Amazonas (UFAM), 6200 General Rodrigo, Manaus 69077-000, Brazil
4
Faculty of Pharmaceutical Science, Federal University of Amazonas (UFAM), 6200 General Rodrigo, Manaus 69077-000, Brazil
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(3), 534; https://doi.org/10.3390/molecules23030534
Received: 23 January 2018 / Revised: 14 February 2018 / Accepted: 22 February 2018 / Published: 27 February 2018
(This article belongs to the Special Issue Plant Derived Natural Products and Age Related Diseases)
The tree popularly known in Brazil as mulateiro or pau-mulato (Calycophyllum spruceanum (Benth.) K. Schum.) is deeply embedded in the herbal medicine of the Amazon region. Different preparations of the bark are claimed to have anti-aging, antioxidant, antimicrobial, emollient, wound healing, hemostatic, contraceptive, stimulant, and anti-diabetic properties. The current study aims to provide the first step towards a science-based evidence of the beneficial effects of C. spruceanum in the promotion of longevity and in the modulation of age-related markers. For this investigation, we used the model system Caenorhabditis elegans to evaluate in vivo antioxidant and anti-aging activity of a water extract from C. spruceanum. To chemically characterize the extract, HPLC MS (High Performance Liquid Chromatography Mass Spectrometry)/MS analyses were performed. Five secondary metabolites were identified in the extract, namely gardenoside, 5-hydroxymorin, cyanidin, taxifolin, and 5-hydroxy-6-methoxycoumarin-7-glucoside. C. spruceanum extract was able to enhance stress resistance and to extend lifespan along with attenuation of aging-associated markers in C. elegans. The demonstrated bioactivities apparently depend on the DAF-16/FOXO pathway. The data might support the popular claims of mulateiro as the “tree of youth”, however more studies are needed to clarify its putative benefits to human health. View Full-Text
Keywords: Caenorhabditis elegans; antioxidants; oxidative stress; aging; Calycophyllum spruceanum Caenorhabditis elegans; antioxidants; oxidative stress; aging; Calycophyllum spruceanum
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Peixoto, H.; Roxo, M.; Koolen, H.; Da Silva, F.; Silva, E.; Braun, M.S.; Wang, X.; Wink, M. Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans. Molecules 2018, 23, 534.

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