Next Article in Journal
Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine αS1-Casein
Next Article in Special Issue
Phytochemical Composition of the Decoctions of Greek Edible Greens (Chórta) and Evaluation of Antioxidant and Cytotoxic Properties
Previous Article in Journal
Sterol Composition of Clinically Relevant Mucorales and Changes Resulting from Posaconazole Treatment
Previous Article in Special Issue
Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources—The MediHealth Project
Open AccessFeature PaperReview

Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing

Institute for Biomedical Aging Research, University of Innsbruck, 6020 Innsbruck, Austria
Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece
Authors to whom correspondence should be addressed.
Molecules 2018, 23(5), 1219;
Received: 13 April 2018 / Revised: 9 May 2018 / Accepted: 13 May 2018 / Published: 19 May 2018
(This article belongs to the Special Issue Plant Derived Natural Products and Age Related Diseases)
Organismal ageing is associated with increased chance of morbidity or mortality and it is driven by diverse molecular pathways that are affected by both environmental and genetic factors. The progression of ageing correlates with the gradual accumulation of stressors and damaged biomolecules due to the time-dependent decline of stress resistance and functional capacity, which eventually compromise cellular homeodynamics. As protein machines carry out the majority of cellular functions, proteome quality control is critical for cellular functionality and is carried out through the curating activity of the proteostasis network (PN). Key components of the PN are the two main degradation machineries, namely the ubiquitin-proteasome and autophagy-lysosome pathways along with several stress-responsive pathways, such as that of nuclear factor erythroid 2-related factor 2 (Nrf2), which mobilises cytoprotective genomic responses against oxidative and/or xenobiotic damage. Reportedly, genetic or dietary interventions that activate components of the PN delay ageing in evolutionarily diverse organisms. Natural products (extracts or pure compounds) represent an extraordinary inventory of highly diverse structural scaffolds that offer promising activities towards meeting the challenge of increasing healthspan and/or delaying ageing (e.g., spermidine, quercetin or sulforaphane). Herein, we review those natural compounds that have been found to activate proteostatic and/or anti-stress cellular responses and hence have the potential to delay cellular senescence and/or in vivo ageing. View Full-Text
Keywords: autophagy; proteasome; proteostasis network; natural products; Nrf2 autophagy; proteasome; proteostasis network; natural products; Nrf2
Show Figures

Figure 1

MDPI and ACS Style

Wedel, S.; Manola, M.; Cavinato, M.; Trougakos, I.P.; Jansen-Dürr, P. Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing. Molecules 2018, 23, 1219.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop