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Molecules 2018, 23(5), 1097; https://doi.org/10.3390/molecules23051097

Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources—The MediHealth Project

1
Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria
2
Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece
3
Department of New Business Development, Galenica SA, 14564 Kiffisia, Greece
4
Laboratory of Organic Chemistry, Natural Substances Team, Faculty of Sciences of Sfax, University of Sfax, PB 1171, 3000 Sfax, Tunisia
5
Department of Research and Development, VivaCell Biotechnology GmbH, 79211 Denzlingen, Germany
6
Natural Products and Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, 2610 Antwerp, Belgium
7
Institute of Biomedical Aging Research and CMBI, University of Innsbruck, 6020 Innsbruck, Austria
8
Department of Chemistry, Catholic University of the North, Casilla, Antofagasta 1280, Chile
9
Department of Analytical Research, Bionorica research GmbH, 6020 Innsbruck, Austria
10
Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh City 700000, Vietnam
11
Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece
12
Center for Natural Products in Drug Development, Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria 0001, South Africa
13
Phytochemistry and Bioactive Natural Products and Pharmacognosy, School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, 1211 Geneva 4, Switzerland
14
Department of Health Science and Technology, Laboratory of Translational Nutrition Biology, Swiss Federal Institute of Technology (ETH) Zürich, 8603 Schwerzenbach, Switzerland
15
Department of Research and Development, Rousselet Centrifugation SA, 07100 Annonay, France
*
Author to whom correspondence should be addressed.
Received: 10 April 2018 / Revised: 23 April 2018 / Accepted: 1 May 2018 / Published: 6 May 2018
(This article belongs to the Special Issue Plant Derived Natural Products and Age Related Diseases)
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Abstract

There is a rapid increase in the percentage of elderly people in Europe. Consequently, the prevalence of age-related diseases will also significantly increase. Therefore, the main goal of MediHealth, an international research project, is to introduce a novel approach for the discovery of active agents of food plants from the Mediterranean diet and other global sources that promote healthy ageing. To achieve this goal, a series of plants from the Mediterranean diet and food plants from other origins are carefully selected and subjected to in silico, cell-based, in vivo (fly and mouse models), and metabolism analyses. Advanced analytical techniques complement the bio-evaluation process for the efficient isolation and identification of the bioactive plant constituents. Furthermore, pharmacological profiling of bioactive natural products, as well as the identification and synthesis of their metabolites, is carried out. Finally, optimization studies are performed in order to proceed to the development of innovative nutraceuticals, dietary supplements or herbal medicinal products. The project is based on an exchange of researchers between nine universities and four companies from European and non-European countries, exploiting the existing complementary multidisciplinary expertise. Herein, the unique and novel approach of this interdisciplinary project is presented. View Full-Text
Keywords: MediHealth; healthy ageing; Mediterranean diet; food plants; natural products; metabolites; bioavailability; pharmacology; phytochemistry; synthetic chemistry MediHealth; healthy ageing; Mediterranean diet; food plants; natural products; metabolites; bioavailability; pharmacology; phytochemistry; synthetic chemistry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Waltenberger, B.; Halabalaki, M.; Schwaiger, S.; Adamopoulos, N.; Allouche, N.; Fiebich, B.L.; Hermans, N.; Jansen-Dürr, P.; Kesternich, V.; Pieters, L.; Schönbichler, S.; Skaltsounis, A.-L.; Tran, H.; Trougakos, I.P.; Viljoen, A.; Wolfender, J.-L.; Wolfrum, C.; Xynos, N.; Stuppner, H. Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources—The MediHealth Project. Molecules 2018, 23, 1097.

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