Medicinal Chemistry in Europe II

Dear Colleagues,

Medicinal chemistry uses physical, chemical, biochemical, molecular biological, immunological, genetic, and computer technology methods, the versatile understanding of which contributes to progress in the research, manufacturing, evaluation, and control of chemical drugs/pharmaceutics. It is evident that medicinal (or pharmaceutical) chemistry is an interdisciplinary branch that has its “roots“ in all chemical and biological sciences; nevertheless, the unique area of its interests lies in the search of structure–activity relationships (relationships between the chemical structure and the biological effect of potential drugs). Thus, medicinal chemistry is focused on the study of essential knowledge and explanation of the mechanism of action, structure–activity relationships, biodynamic behavior, and chemical reactivity of drugs. Since its beginnings, from Paracelsus (1493–1541), the father of chemiatria, over chemical laboratories in apothecaries of the 18th and 19th centuries, to these days, medicinal chemistry has come a long way. Thus, although inspiration is still derived from nature (secondary metabolites) with the new millennium in the design of new drugs, it is possible to trace the effort to develop drugs “designed” based on the precise knowledge of structural biology (genomics) and other molecular–biological–chemical sciences. With respect to the abovementioned facts, this Special Issue of Molecules titled “Medicinal Chemistry in Europe II” is devoted to the following research topics focused on all fields of medicinal chemistry: (i) drug design; (ii) natural compounds; (iii) synthesis and analysis; (iv) study of physicochemical parameters of drugs; (v) in silico investigations; (vi) biological screening; (vii) chemical biology and biological chemistry; (vii) biomaterials; (viii) excipients; and (ix) diagnostics, and in general, other topics related to design, discovery, research, and development of biologically active agents.

Prof. Dr. Josef Jampilek
Dr. Robert Musiol
Guest Editors

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