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Advances in the Synthesis of Heterocyclic Compounds and Their Applications, 2nd Edition

A Special Issue of Molecules (ISSN 1420-3049) belonging to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1874

Editors


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Guest Editor
Department of Chemistry, Faculty of Chemistry and Chemical Engineering, University Babes-Bolyai Cluj-Napoca, 11 Aranyi Janos str., 400028 Cluj-Napoca, Romania
Interests: organic synthesis; heterocyclic chemistry; pharmaceutical chemistry; nuclear magnetic resonance; natural product chemistry; organometallics; dendritic chemistry; stereochemistry
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Guest Editor
Chemistry Department, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania
Interests: heterocycles; medicinal chemistry; anticancer; antituberculosis; microwave; ultrasounds; organic synthesis

Special Issue Information

Dear Colleagues,

The recent positive impact of the first edition of our Special Issue, "Advances in the Synthesis of Heterocyclic Compounds and their Applications", prompted us to continue with a second edition on the same topic. This second edition aims to explore two interfaces: human life and the environment.

In this view, previous strategies, "heteroring synthesis" and "substituent modification" (and their combination), require an updated definition because of two conceptual approaches, namely "covalent" vs. "non-covalent", with reference to all types of heteromolecules, from the smallest to (supramolecular) 2- or 3D nano-architectures (dendrimers, MOFs, COFs, etc.), without neglecting the still "exotic" molecular machines.

Subject to all evolutionary facets of heterocyclic chemistry, perpetual developments reimagined within the current field of organic heterosynthesis (strategies, methodologies, reaction mechanisms, reagents, catalysts, chemical and instrumental auxiliaries) nevertheless obey two crucial common denominators, "selectivity" vs. “specificity” (these terms being, equally, preceded by typical prefixes, either chemo-, regio- or stereo-), as a mandatory criteriums.

This Special Issue of Molecules is intended to gather research articles, communications, and review papers that provide an overview of the latest progresses in synthetic methodologies and chemical technologies targeting heteromolecules, mainly those related to their near-future, defined as "atomic precision" in chemical reactivity. The sustainability of these efforts, involving intrinsic chemical diversity, is expected to highlight innovative applications of heterocyclic compounds to human life and the environment.

Prof. Dr. Mircea Darabantu
Prof. Dr. Ionel Mangalagiu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetics and new chemical entities (NCEs)
  • domino reactions
  • "intelligent" molecules
  • iterative synthesis
  • multicomponent reactions
  • organic (nano-)materials
  • organo-catalytic systems
  • selective processes
  • total synthesis
  • unconventional methods and techniques

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Related Special Issue

Published Papers (2 papers)

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Research

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17 pages, 1275 KB  
Article
Imidazole-Based AT1 Receptor Ligands: Design, Synthesis and Pharmacological Evaluation
by Florian Descamps, Marouane Rami, Jean-François Goossens, Patricia Melnyk, Maxime Liberelle and Saïd Yous
Molecules 2026, 31(11), 1971; https://doi.org/10.3390/molecules31111971 - 5 Jun 2026
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Abstract
The angiotensin II type 1 (AT1) receptor is a key component of the renin–angiotensin system (RAS) and a validated target for cardiovascular and renal disorders. Developing small molecules with defined AT1 versus AT2 binding profiles remains important for both [...] Read more.
The angiotensin II type 1 (AT1) receptor is a key component of the renin–angiotensin system (RAS) and a validated target for cardiovascular and renal disorders. Developing small molecules with defined AT1 versus AT2 binding profiles remains important for both therapeutic and mechanistic studies. Here, a series of novel imidazole-based compounds was synthesized and evaluated for their binding affinities toward angiotensin II type 1 (AT1) and type 2 (AT2) receptors. Binding studies were conducted by measuring the displacement of radiolabeled [3H]-angiotensin II ([3H]-AII) in PLC-PRF-5 human hepatoma cells for AT1 receptors and calf cerebellum membranes for AT2 receptors. Structure–activity relationship (SAR) analysis revealed that sulfonamide substitution significantly enhanced AT1 receptor affinity, whereas sterically hindered derivatives and ester-containing compounds were less active. Molecular docking studies using the AT1 receptor crystal structure (PDB: 8TH4) rationalized the observed activity trends. The most active compound showed high AT1 affinity (Ki = 5 nM), comparable to losartan, and all compounds displayed preferential binding for AT1 over AT2 receptors. Full article
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Review

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64 pages, 35278 KB  
Review
1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications
by Egor V. Verbitskiy, Elizaveta M. Krynina, Yuriy A. Kvashnin and Valery N. Charushin
Molecules 2026, 31(12), 2197; https://doi.org/10.3390/molecules31122197 - 22 Jun 2026
Cited by 2 | Viewed by 943
Abstract
This review highlights the recent advances in the synthesis of 1,4-diazatriphenylenes and their various structural analogs. It focuses on several methodologies, including condensation reactions and intramolecular cyclizations of 2,3-di(het)aryl-substituted pyrazine derivatives. These methods exploit either oxidative photocyclization (the Mallory reaction), intramolecular cyclodehydrogenation (the [...] Read more.
This review highlights the recent advances in the synthesis of 1,4-diazatriphenylenes and their various structural analogs. It focuses on several methodologies, including condensation reactions and intramolecular cyclizations of 2,3-di(het)aryl-substituted pyrazine derivatives. These methods exploit either oxidative photocyclization (the Mallory reaction), intramolecular cyclodehydrogenation (the Scholl reaction), or intramolecular SNH reactions (nucleophilic aromatic substitution of hydrogen) involving 2-bis(het)aryl-substituted 1,4-diazine derivatives. Additionally, the review explores the potential applications of these compounds as fluorescent and/or semiconducting materials in organic electronics, as well as their role in coordination chemistry and biological issues. It summarizes the literature from 2018 to March 2026, complementing the data discussed in our previous review. Full article
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