Next Article in Journal
Design, Synthesis and Biological Evaluation of Nitrate Derivatives of Sauropunol A and B as Potent Vasodilatory Agents
Next Article in Special Issue
Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents
Previous Article in Journal
Elucidation of the Mechanism of Action for Metal Based Anticancer Drugs by Mass Spectrometry-Based Quantitative Proteomics
Previous Article in Special Issue
Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA)
Open AccessReview

Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects

1
Integrative and Functional Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi-110025, India
2
Academy of Scientific and Innovative Research, Rafi Marg, New Delhi-110001, India
3
GNR Knowledge Centre for Genome Informatics, CSIR Institute of Genomics and Integrative Biology, Mathura Road, New Delhi-110025, India
*
Author to whom correspondence should be addressed.
Academic Editor: Danzhou Yang
Molecules 2019, 24(3), 582; https://doi.org/10.3390/molecules24030582
Received: 27 November 2018 / Revised: 31 January 2019 / Accepted: 1 February 2019 / Published: 6 February 2019
(This article belongs to the Special Issue G-Quadruplex Ligands and Cancer)
Evidences from more than three decades of work support the function of non-duplex DNA structures called G-quadruplex (G4) in important processes like transcription and replication. In addition, G4 structures have been studied in connection with DNA base modifications and chromatin/nucleosome arrangements. Recent work, interestingly, shows promise of G4 structures, through interaction with G4 structure-interacting proteins, in epigenetics—in both DNA and histone modification. Epigenetic changes are found to be intricately associated with initiation as well as progression of cancer. Multiple oncogenes have been reported to harbor the G4 structure at regulatory regions. In this context, G4 structure-binding ligands attain significance as molecules with potential to modify the epigenetic state of chromatin. Here, using examples from recent studies we discuss the emerging role of G4 structures in epigenetic modifications and, therefore, the promise of G4 structure-binding ligands in epigenetic therapy. View Full-Text
Keywords: epigenetics; G4-interacting proteins; dietary G4 structure-binding molecules; histones; chromatin; replication epigenetics; G4-interacting proteins; dietary G4 structure-binding molecules; histones; chromatin; replication
Show Figures

Figure 1

MDPI and ACS Style

Sengupta, A.; Ganguly, A.; Chowdhury, S. Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects. Molecules 2019, 24, 582.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop