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Molecules 2019, 24(5), 965; https://doi.org/10.3390/molecules24050965

Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands

Laboratory of Bioanalytical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Umultowska Street 89b, 61-614 Poznań, Poland
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Academic Editor: Derek J. McPhee
Received: 13 January 2019 / Revised: 25 February 2019 / Accepted: 6 March 2019 / Published: 9 March 2019
(This article belongs to the Special Issue G-Quadruplex Ligands and Cancer)
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Abstract

Microwave formylation of carbazole derivatives was investigated and 3-monoaldehydes were obtained in high yield. A potential DNA-binding ligand, 3-[(3-ethyl)-2-vinylbenzothiazolium]-9-N-ethyl carbazole iodide, was synthesized and characterized including spectral properties (UV-Vis absorption and fluorescence spectra). The binding selectivity and affinity of three carbazole ligands for double-stranded and G-quadruplex DNA structures were studied using a competitive dialysis method in sodium- and potassium-containing buffer solutions. View Full-Text
Keywords: microwave synthesis; G-quadruplex ligands; carbazole derivatives; equilibrium dialysis method microwave synthesis; G-quadruplex ligands; carbazole derivatives; equilibrium dialysis method
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Głuszyńska, A.; Juskowiak, B. Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands. Molecules 2019, 24, 965.

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