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Lipids and Surfactants in Delivery Systems

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 22 July 2025 | Viewed by 1939

Special Issue Editors


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Guest Editor
Faculty of Chemistry, University of Wroclaw, 14 Joliot-Curie Street, 50-383 Wroclaw, Poland
Interests: surfactants; aggregates; delivery systems; biomaterials; nanocarriers; active compounds

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Guest Editor Assistant
Faculty of Biotechnology, University of Wroclaw, Joliot Curie 14a, 50-383 Wroclaw, Poland
Interests: nanotechnology; delivery systems; biomaterials; biopolymers; biological activity of natural compounds

Special Issue Information

Dear Colleagues,

We invite you to submit your article for publication in this Special Issue entitled “Lipids and Surfactants in Delivery Systems”.

The development of lipid- and surfactant-based delivery systems is directed toward a wide range of applications, including cosmetics, oral delivery of active compounds, treatment of chronic diseases, and improving vaccine efficacy. Modern research trends emphasize the design of stimuli-responsive systems that release their cargo under specific conditions, the integration of nanotechnology to enable precision targeting, and the exploration of natural and sustainable lipid sources. Furthermore, advanced analytical techniques and computational modeling are increasingly employed to understand and optimize these systems' structure–function relationships, paving the way for more efficient and safer therapeutic applications.

Lipid- and surfactant-based carriers play a crucial role in the encapsulation and delivery of sensitive nutrients, antioxidants, and functional ingredients. By enhancing the bioavailability and stability of these compounds, these carriers support the development of fortified and functional products tailored to specific needs. Their incorporation into food, cosmetic, or pharmaceutical products not only facilitates the delivery of active substances to the body but also improves sensory properties, enables controlled bioactive release during digestion for targeted absorption, enhances product texture, supports skin penetration, and ensures targeted action in specific areas, thereby maximizing health benefits. These advancements emphasize the growing synergy between industry and biomedical sciences, showcasing the transformative potential of lipid- and surfactant-based carriers across both health and industrial sectors.

This Special Issue will explore the design, development, and application of lipid- and surfactant-based carriers for the efficient transport of bioactive molecules. This interdisciplinary area integrates principles of chemistry, biophysics, and pharmaceutical sciences to address challenges in drug delivery, the cosmetic and food industries, diagnostics, and therapeutic efficacy.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

  • Liposome, solid lipid nanoparticle (SLN), and nanostructured lipid carrier (NLC) nanoemulsions;
  • Hybrid systems with lipids, surfactants, and polymers;
  • Molecular interactions between lipids, surfactants, and active agents;
  • Integration of nanotechnology and responsive delivery mechanisms (e.g., pH-sensitive, stimuli-responsive systems);
  • Personalized system and precision delivery approaches;
  • Green and sustainable surfactants and lipids in formulation;
  • Applications in oral, transdermal, and parenteral delivery.

We look forward to receiving your contributions.

Dr. Agnieszka Lewińska
Guest Editor

Dr. Marta Domżał-Kędzia
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • delivery systems
  • controlled-release systems
  • targeted delivery systems
  • preparation and characterization
  • surfactant–lipid interactions
  • lipid and surfactant nanocarriers
  • bioavailability enhancement
  • nanotechnology

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Published Papers (2 papers)

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Research

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22 pages, 2885 KiB  
Article
Structure Elucidation and Characterization of Novel Glycolipid Biosurfactant Produced by Rouxiella badensis DSM 100043T
by Andre Fahriz Perdana Harahap, Jürgen Conrad, Mario Wolf, Jens Pfannstiel, Iris Klaiber, Jakob Grether, Eric Hiller, Maliheh Vahidinasab, Hanna Salminen, Chantal Treinen, Elvio Henrique Benatto Perino and Rudolf Hausmann
Molecules 2025, 30(8), 1798; https://doi.org/10.3390/molecules30081798 - 17 Apr 2025
Viewed by 335
Abstract
Microbial biosurfactants have become increasingly attractive as promising ingredients for environmentally friendly products. The reasons for this are their generally good performance and biodegradability, low toxicity, production from renewable raw materials, and benefits for the environment perceived by consumers. In this study, we [...] Read more.
Microbial biosurfactants have become increasingly attractive as promising ingredients for environmentally friendly products. The reasons for this are their generally good performance and biodegradability, low toxicity, production from renewable raw materials, and benefits for the environment perceived by consumers. In this study, we investigated the chemical structure and properties of a novel glycolipid from a new biosurfactant-producing strain, Rouxiella badensis DSM 100043T. Bioreactor cultivation was performed at 30 °C and pH 7.0 for 28 h using 15 g/L glycerol as a carbon source. The glycolipid was successfully purified from the ethyl acetate extract of the supernatant using medium pressure liquid chromatography (MPLC). The structure of the glycolipid was determined by one- and two-dimensional (1H and 13C) nuclear magnetic resonance (NMR) and confirmed by liquid chromatography electrospray ionization mass spectrometry (LC-ESI/MS). NMR analysis revealed the hydrophilic moiety as a glucose molecule and the hydrophobic moieties as 3-hydroxy-5-dodecenoic acid and 3-hydroxydecanoic acid, which are linked with the glucose by ester bonds at the C2 and C3 positions. Surface tension measurement with tensiometry indicated that the glucose–lipid could reduce the surface tension of water from 72.05 mN/m to 24.59 mN/m at 25 °C with a very low critical micelle concentration (CMC) of 5.69 mg/L. Moreover, the glucose–lipid demonstrated very good stability in maintaining emulsification activity at pH 2–8, a temperature of up to 100 °C, and a NaCl concentration of up to 15%. These results show that R. badensis DSM 100043T produced a novel glycolipid biosurfactant with excellent surface-active properties, making it promising for further research or industrial applications. Full article
(This article belongs to the Special Issue Lipids and Surfactants in Delivery Systems)
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Review

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33 pages, 1309 KiB  
Review
The Pharmaceutical and Pharmacological Potential Applications of Bilosomes as Nanocarriers for Drug Delivery
by Darko Mitrović, Dragana Zaklan, Maja Đanić, Bojan Stanimirov, Karmen Stankov, Hani Al-Salami and Nebojša Pavlović
Molecules 2025, 30(5), 1181; https://doi.org/10.3390/molecules30051181 - 6 Mar 2025
Cited by 2 | Viewed by 1304
Abstract
Nano-drug delivery systems provide targeted solutions for addressing various drug delivery challenges, leveraging nanotechnology to enhance drug solubility and permeability. Liposomes, explored for several decades, face hurdles, especially in oral delivery. Bile-acid stabilized vesicles (bilosomes) are flexible lipid vesicles, composed of phospholipids or [...] Read more.
Nano-drug delivery systems provide targeted solutions for addressing various drug delivery challenges, leveraging nanotechnology to enhance drug solubility and permeability. Liposomes, explored for several decades, face hurdles, especially in oral delivery. Bile-acid stabilized vesicles (bilosomes) are flexible lipid vesicles, composed of phospholipids or other surfactants, along with amphiphilic bile salts, and they show superior stability and pharmacokinetic behavior in comparison to conventional vesicular systems (liposomes and niosomes). Bilosomes enhance skin penetration, fluidize the stratum corneum, and improve drug stability. In oral applications, bilosomes overcome drawbacks, offering improved bioavailability, controlled release, and reduced side effects. Vaccines using bilosomes demonstrate efficacy, and bilosomes for intranasal, inhalation, ocular, and buccal applications enhance drug delivery, offering targeted, efficient, and controlled activities. Formulations vary based on active substances and optimization techniques, showcasing the versatility and potential of bilosomes across diverse drug delivery routes. Therefore, the aim of this comprehensive review was to critically explore the state-of-the-art of bilosomes in drug delivery and potential therapeutic applications. Full article
(This article belongs to the Special Issue Lipids and Surfactants in Delivery Systems)
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