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Recent Advances in (Phospho)lipid-Based Drug Delivery Nanosystems
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Recent Advances in (Phospho)lipid-Based Drug Delivery Nanosystems

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Macromolecular Chemistry".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 5234

Special Issue Editor

Prof. Dr. Željka Vanić

E-Mail Website
Guest Editor
Department of Pharmaceutics, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
Interests: liposomes; deformable liposomes; propylene glycol liposomes; pH-sensitive liposomes; liposomal hydrogels; vesicular phospholipid gel; (trans)dermal drug delivery; vaginal drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanotechnology plays an important role in improving drug delivery and therapeutic efficacy, offering targeted, localized, controlled and/or prolonged delivery of encapsulated drugs to the desired sites of action in the body while reducing unwanted side-effects and toxicity. Among the various drug nanoformulations that are clinically available, (phospho)lipid-based nanosystems are of particular importance due to their versatility and unique properties. They are biodegradable, biocompatible, and non-toxic and enable the incorporation of different drugs (active compounds, herbal substances, enzymes) varying in lipophilicity and size. (Phospho)lipid-based nanosystems include different types of liposomes that differ in size, morphology, design and surface properties, solid lipid nanoparticles, nanostructured lipid carriers, niosomes, nanoemulsions, and microemulsions. The physicochemical properties of (phospho)lipid-based nanosystems are determined by their composition and drug release profile, the stability of the nanosystem during storage, drug permeation through biological barriers/membranes and interactions with the cells, thus affecting drug bioavailability and therapeutic efficacy. Clinical applications of (phospho)lipid-based drug delivery nanosystems include a variety of nanoformulations for the treatment of infectious diseases, cancer, vaccination, inflammation and pain relief, and are applied by various routes of drug administration.

This Special Issue aims to present recent advances in (phospho)lipid-based drug delivery nanosystems and addresses their design, development, characterization, quality, safety, pharmacodynamic and pharmacokinetic properties.

Prof. Dr. Željka Vanić
Guest Editor

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liposomes
  • solid lipid nanoparticles
  • nanostructured lipid carriers
  • nanoemulsions
  • niosomes
  • controlled drug delivery
  • targeted drug delivery
  • topical drug delivery
  • parenteral drug delivery

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Published Papers (3 papers)

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Research

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16 pages, 5726 KiB  
Article
A New Wound-Healing Tool Based on Glycyrrhiza glabra Extract-Loaded Ufasomes on Spanish Broom Dressings
by Simone Rossello, Manuela Mandrone, Teresa Cerchiara, Ilaria Chiocchio, Martina Rossi, Fabio Chinnici, Valentina Sallustio, Maria Aponte, Giuseppe Blaiotta, Barbara Luppi, Angela Abruzzo, Federica Bigucci and Concettina Cappadone
Molecules 2024, 29(16), 3811; https://doi.org/10.3390/molecules29163811 - 11 Aug 2024
Cited by 1 | Viewed by 1505
Abstract
The development of innovative products for restoring skin integrity and promoting wound healing is still a challenge. The aim of this work was to evaluate an innovative Spanish broom wound dressing impregnated with Glycyrrhiza glabra extract-loaded ufasomes to improve wound healing. Ufasomes were [...] Read more.
The development of innovative products for restoring skin integrity and promoting wound healing is still a challenge. The aim of this work was to evaluate an innovative Spanish broom wound dressing impregnated with Glycyrrhiza glabra extract-loaded ufasomes to improve wound healing. Ufasomes were characterized in terms of size, polydispersity index, entrapment efficiency, zeta potential, and stability. In addition, in vitro release studies and biocompatibility, biosafety, and scratch tests on WS1 fibroblasts were performed. The loaded ufasomes showed a nanometric size (<250 nm), good size distribution (lower than 0.3), and appropriate encapsulation efficiency (~67%). Moreover, the lipid vesicles showed good stability during the storage period and allowed for a slow release of glycyrrhizin, the main bioactive compound of the extract. Biological studies revealed that loaded vesicles are not cytotoxic, are hemocompatible, and lead to the complete closure of the scratch after about 33 h. To conclude, the results suggest that the developed dressings can be efficiently used to promote the healing process. Full article
(This article belongs to the Special Issue Recent Advances in (Phospho)lipid-Based Drug Delivery Nanosystems)
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20 pages, 15976 KiB  
Article
The Impact of Phospholipid-Based Liquid Crystals’ Microstructure on Stability and Release Profile of Ascorbyl Palmitate and Skin Performance
by Alenka Zvonar Pobirk, Robert Roškar, Marija Bešter-Rogač, Mirjana Gašperlin and Mirjam Gosenca Matjaž
Molecules 2024, 29(13), 3173; https://doi.org/10.3390/molecules29133173 - 3 Jul 2024
Cited by 1 | Viewed by 1536
Abstract
The drug delivery potential of liquid crystals (LCs) for ascorbyl palmitate (AP) was assessed, with the emphasis on the AP stability and release profile linked to microstructural rearrangement taking place along the dilution line being investigated by a set of complementary techniques. With [...] Read more.
The drug delivery potential of liquid crystals (LCs) for ascorbyl palmitate (AP) was assessed, with the emphasis on the AP stability and release profile linked to microstructural rearrangement taking place along the dilution line being investigated by a set of complementary techniques. With high AP degradation observed after 56 days, two stabilization approaches, i.e., the addition of vitamin C or increasing AP concentration, were proposed. As a rule, LC samples with the lowest water content resulted in better AP stability (up to 52% of nondegraded AP in LC1 after 28 days) and faster API release (~18% in 8 h) as compared to the most diluted sample (29% of nondegraded AP in LC8 after 28 days, and up to 12% of AP released in 8 h). In addition, LCs exhibited a skin barrier-strengthening effect with up to 1.2-fold lower transepidermal water loss (TEWL) and 1.9-fold higher skin hydration observed in vitro on the porcine skin model. Although the latter cannot be linked to LCs’ composition or specific microstructure, the obtained insight into LCs’ microstructure contributed greatly to our understanding of AP positioning inside the system and its release profile, also influencing the overall LCs’ performance after dermal application. Full article
(This article belongs to the Special Issue Recent Advances in (Phospho)lipid-Based Drug Delivery Nanosystems)
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Review

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22 pages, 1789 KiB  
Review
Liposome-Assisted Drug Delivery in the Treatment of Multiple Sclerosis
by Giuliana Greco and Maria Grazia Sarpietro
Molecules 2024, 29(19), 4689; https://doi.org/10.3390/molecules29194689 - 3 Oct 2024
Cited by 1 | Viewed by 1594
Abstract
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the nervous system that leads to neurological dysfunctions and severe disabilities. It is worth noting that conventional pharmacotherapy is poorly selective and causes toxicity problems and several systemic side effects. Thus, there is a [...] Read more.
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the nervous system that leads to neurological dysfunctions and severe disabilities. It is worth noting that conventional pharmacotherapy is poorly selective and causes toxicity problems and several systemic side effects. Thus, there is a need to develop new approaches to this medical challenge. The use of nanocarriers for drug delivery represents a good strategy to overcome several issues such as high therapeutic drug doses with side effects, such as diarrhea, nausea, and abdominal pain, and drug degradation processes; in addition, nanocarriers can provide controlled and targeted drug release. This review describes the application of liposomes for the delivery of pharmaceutical actives to target MS. Firstly, MS is explained. Then, liposomes are described along with their preparation, characterization, and stability. The literature about the use of liposomes for the treatment of MS is then analyzed. Full article
(This article belongs to the Special Issue Recent Advances in (Phospho)lipid-Based Drug Delivery Nanosystems)
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