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Advances in the Formulation of Nanocarriers for Healthcare and Environmental Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 2126

Special Issue Editors


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Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
Interests: pickering emulsions; food-grade Pickering particles; drug delivery systems; smart pollutant recovery systems; polymer-dispersed liquid crystals (PDLCs); photochromic nematic emulsions

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Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
Interests: vesicular system; drug delivery; transdermal drug delivery; colloidal systems; drug targeting; nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanocarriers, due to their small size, have unique properties which make them appealing in many application areas. Using different types of nanosystems, it is possible to obtain more well-constructed and smarter products in many areas linked to human health, from medicine to the food industry, without neglecting environmental protection and animal farm welfare.

In recent decades, research on nanotechnologies has increasingly been directed beyond the field of nanodrugs and nanomedicine to the agrifood and livestock sectors, obtaining encouraging results.

As Guest Editors, we would like to encourage potential contributors to submit their original research in the form of full papers, communications, and critical reviews, on all aspects related to the title of this Special Issue: “Advances in the formulation of Nanocarriers for Healthcare and environmental applications”.

Research areas may include the following:

  • Drug delivery systems;
  • Nanomedicines;
  • Nanotechnologies in agrifood and livestock fields;
  • Nanocarriers for target-specific pollutant capture;
  • Sustainable nanocarriers for environmental management and remediation.

Dr. Patrizia Formoso
Prof. Dr. Rita Muzzalupo
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems
  • nanomedicines
  • nanotechnologies in agrifood and livestock fields
  • nanocarriers for target-specific pollutant capture
  • sustainable nanocarriers for environmental management and remediation

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Published Papers (2 papers)

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Research

14 pages, 2548 KiB  
Article
Fabrication of a Heptapeptide-Modified Poly(glycidyl Methac-Rylate) Nanosphere for Oriented Antibody Immobilization and Immunoassay
by Xiaoxing Gong, Jie Zhang, Liyan Zhu, Shu Bai, Linling Yu and Yan Sun
Molecules 2024, 29(19), 4635; https://doi.org/10.3390/molecules29194635 - 29 Sep 2024
Viewed by 335
Abstract
Oriented antibody immobilization has been widely employed in immunoassays and immunodiagnoses due to its efficacy in identifying target antigens. Herein, a heptapeptide ligand, HWRGWVC (HC7), was coupled to poly(glycidyl methacrylate) (PGMA) nanospheres (PGMA-HC7). The antibody immobilization behavior and antigen recognition performance were investigated [...] Read more.
Oriented antibody immobilization has been widely employed in immunoassays and immunodiagnoses due to its efficacy in identifying target antigens. Herein, a heptapeptide ligand, HWRGWVC (HC7), was coupled to poly(glycidyl methacrylate) (PGMA) nanospheres (PGMA-HC7). The antibody immobilization behavior and antigen recognition performance were investigated and compared with those on PGMA nanospheres by nonspecific adsorption and covalent coupling via carbodiimide chemistry. The antibodies tested included bovine, rabbit, and human immunoglobulin G (IgG), while the antigens included horseradish peroxidase (HRP) and β-2-Microglobulin (β2-MG). The nanospheres were characterized using zeta potential and particle size analyzers, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and reversed-phase chromatography, proving each synthesis step was succeeded. Isothermal titration calorimetry assay demonstrated the strong affinity interaction between IgG and PGMA-HC7. Notably, PGMA-HC7 achieved rapid and extremely high IgG adsorption capacity (~3 mg/mg) within 5 min via a specific recognition via HC7 without nonspecific interactions. Moreover, the activities of immobilized anti-HRP and anti-β2-MG antibodies obtained via affinity binding were 1.5-fold and 2-fold higher than those of their covalent coupling counterparts. Further, the oriented-immobilized anti-β2-MG antibody on PGMA-HC7 exhibited excellent performance in antigen recognition with a linear detection range of 0–5.3 μg/mL, proving its great potential in immunoassay applications. Full article
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23 pages, 7731 KiB  
Article
Herbicide and Cytogenotoxic Activity of Inclusion Complexes of Psidium gaudichaudianum Leaf Essential Oil and β-Caryophyllene on 2-Hydroxypropyl-β-cyclodextrin
by Luiza Alves Mendes, Loren Cristina Vasconcelos, Milene Miranda Praça Fontes, Geisiele Silva Martins, Aline dos Santos Bergamin, Matheus Alves Silva, Rafael Resende Assis Silva, Taíla Veloso de Oliveira, Victor Gomes Lauriano Souza, Marcia Flores da Silva Ferreira, Róbson Ricardo Teixeira and Renata Pereira Lopes
Molecules 2023, 28(15), 5909; https://doi.org/10.3390/molecules28155909 - 6 Aug 2023
Cited by 3 | Viewed by 1396
Abstract
The present investigation aimed to develop inclusion complexes (ICs) from Psidium gaudichaudianum (GAU) essential oil (EO) and its major compound β-caryophyllene (β-CAR), and to evaluate their herbicidal (against Lolium multiflorum and Bidens pilosa) and cytogenotoxic (on Lactuca sativa) [...] Read more.
The present investigation aimed to develop inclusion complexes (ICs) from Psidium gaudichaudianum (GAU) essential oil (EO) and its major compound β-caryophyllene (β-CAR), and to evaluate their herbicidal (against Lolium multiflorum and Bidens pilosa) and cytogenotoxic (on Lactuca sativa) activities. The ICs were obtained using 2-hydroxypropyl-β-cyclodextrin (HPβCD) and they were prepared to avoid or reduce the volatility and degradation of GAU EO and β-CAR. The ICs obtained showed a complexation efficiency of 91.5 and 83.9% for GAU EO and β-CAR, respectively. The IC of GAU EO at a concentration of 3000 µg mL−1 displayed a significant effect against weed species B. pilosa and L. multiflorum. However, the β-CAR IC at a concentration of 3000 µg mL−1 was effective only on L. multiflorum. In addition, the cytogenotoxic activity evaluation revealed that there was a reduction in the mitotic index and an increase in chromosomal abnormalities. The produced ICs were able to protect the EO and β-CAR from volatility and degradation, with a high thermal stability, and they also enabled the solubilization of the EO and β-CAR in water without the addition of an organic solvent. Therefore, it is possible to indicate the obtained products as potential candidates for commercial exploration since the ICs allow the complexed EO to exhibit a more stable chemical constitution than pure EO under storage conditions. Full article
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