Fluorescent Probes as Powerful Tools in Cancer Detection
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2856
Special Issue Editor
Interests: prodrugs; targeted therapy; diagnostics; theranostics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recently, fluorescence modality has been an indispensable and powerful tool in the diagnosis sector. It provides spatiotemporal images of the target analytes noninvasively. Thus, small-molecule reactive fluorogenic probes used to determine short-lived reactive species in the cellular microenvironment in the pathogenic or nonpathogenic state. The key challenge is to design a probe that is nontoxic, chemo-selective, and well coordinated to detect short-lifetime biological entities within complex biological environments and that can overcome cellular background signals without negatively affecting cellular morphology.
Cancer is a multi-dimensional disease that is heterogenic in nature. It hinders the visualization of the exact nature of the tissue, and is extremely difficult to distinguish normal tissue from cancer tissue using white light. Currently, fluorescence-guided detection is considered one of the most promising approaches with improved tumor visualization efficacy. Namely, two-photon fluorescent probes, photoacoustic probes, and NIR-based fluorescent probes have been effectively utilized in cancer diagnosis. The fluorogenic probes can provide multi-abnormal components in cancer cells in a single stage that reduces the errors in the diagnosis of cancer more efficiently. Indeed, it can help to dissect tumors in the operation theater by providing distinctive tumor surfacing imaging.
Dr. Sankarprasad Bhuniya
Guest Editor
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Keywords
- cancer detection
- cancer cell imaging
- ROS detection
- enzymes in cancer cells
- photoacoustic imaging
- two-photon imaging
- pH probes
- reductase detection
- ALP probes
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