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Micromachines
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Electrochemical Sensors in Biological Applications
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Electrochemical Sensors in Biological Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "C：Chemistry".

Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 11542

Special Issue Editors

Dr. Iulia Gabriela David

E-Mail Website
Guest Editor
Department of Analytical Chemistry and Physical Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Avenue, Bucharest 5, 060274 Bucharest, Romania
Interests: electrochemical sensors; modified electrodes; voltamperometry; potentiometry; electroanalysis
Special Issues, Collections and Topics in MDPI journals
Dr. Mihaela Buleandra

E-Mail Website
Guest Editor
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Avenue, Bucharest 5,060274 Bucharest, Romania
Interests: electroanalytical chemistry; electroactive compounds; bioanalysis; carbon-based materials; method development/validation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Due to their inherent analytical performance characteristics, electrochemical sensors have attracted more and more attention in recent years, being used as detection tools in various applications, an important role being played by biological ones. The plenty of electrode materials as well as the methods and compounds developed for modifying the sensor surfaces, coupled with appropriate electrochemical techniques ensure the sensitivity and selectivity of the sensors, making them suitable for the detection of analytes from complex matrices like pharmaceuticals, biological fluids, food or environmental samples. On the other hand, as they can be miniaturized and employed in portable instruments, sometimes as disposable electrodes, they are easy-to-use and cost-effective analytical devices enabling on-site, real time, on-line and in-line analysis. Considering all these aspects, electrochemical sensors are often the best choice for the rapid and simple detection of various biological active compounds from different matrices. Consequently, the purpose of this special issue, entitled "Electrochemical sensors in biological applications” is to present research papers and review articles that highlight both the current state of research and the latest developments in the field of electrochemical sensors used to detect biological important analytes or to explore their function in biological systems based on their redox behavior.

Dr. Iulia Gabriela David
Dr. Mihaela Buleandra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemical (bio)sensors
  • chemically modified electrodes
  • electroanalysis
  • redox behavior
  • voltamperometry
  • bioactive compounds
  • (bio)medical and biological applications

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Published Papers (4 papers)

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Research

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14 pages, 3071 KiB  
Article
The Interaction between DNA and Three Intercalating Anthracyclines Using Electrochemical DNA Nanobiosensor Based on Metal Nanoparticles Modified Screen-Printed Electrode
by Leyla Karadurmus, Burcu Dogan-Topal, Sevinc Kurbanoglu, Afzal Shah and Sibel A. Ozkan
Micromachines 2021, 12(11), 1337; https://doi.org/10.3390/mi12111337 - 30 Oct 2021
Cited by 13 | Viewed by 1673
Abstract
The screen-printed electrodes have gained increasing importance due to their advantages, such as robustness, portability, and easy handling. The manuscript presents the investigation of the interaction between double-strand deoxyribonucleic acid (dsDNA) and three anthracyclines: epirubicin (EPI), idarubicin (IDA), and doxorubicin (DOX) by differential [...] Read more.
The screen-printed electrodes have gained increasing importance due to their advantages, such as robustness, portability, and easy handling. The manuscript presents the investigation of the interaction between double-strand deoxyribonucleic acid (dsDNA) and three anthracyclines: epirubicin (EPI), idarubicin (IDA), and doxorubicin (DOX) by differential pulse voltammetry on metal nanoparticles modified by screen-printed electrodes. In order to investigate the interaction, the voltammetric signals of dsDNA electroactive bases were used as an indicator. The effect of various metal nanomaterials on the signals of guanine and adenine was evaluated. Moreover, dsDNA/PtNPs/AgNPs/SPE (platinum nanoparticles/silver nanoparticles/screen-printed electrodes) was designed for anthracyclines–dsDNA interaction studies since the layer-by-layer modification strategy of metal nanoparticles increases the surface area. Using the signal of multi-layer calf thymus (ct)-dsDNA, the within-day reproducibility results (RSD%) for guanine and adenine peak currents were found as 0.58% and 0.73%, respectively, and the between-day reproducibility results (RSD%) for guanine and adenine peak currents were found as 1.04% and 1.26%, respectively. The effect of binding time and concentration of three anthracyclines on voltammetric signals of dsDNA bases were also evaluated. The response was examined in the range of 0.3–1.3 ppm EPI, 0.1–1.0 ppm IDA and DOX concentration on dsDNA/PtNPs/AgNPs/SPE. Electrochemical studies proposed that the interaction mechanism between three anthracyclines and dsDNA was an intercalation mode. Full article
(This article belongs to the Special Issue Electrochemical Sensors in Biological Applications)
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17 pages, 4803 KiB  
Article
Disposable Pencil Graphite Electrode for Diosmin Voltammetric Analysis
by Iulia Gabriela David, Alexandra-Gabriela Oancea, Mihaela Buleandră, Dana Elena Popa, Emilia Elena Iorgulescu and Adela Magdalena Ciobanu
Micromachines 2021, 12(4), 351; https://doi.org/10.3390/mi12040351 - 25 Mar 2021
Cited by 6 | Viewed by 2046
Abstract
Diosmin (DIO) is a naturally occurring flavonoid with multiple beneficial effects on human health. The presence of different hydroxyl groups in diosmin structure enables its electrochemical investigation and quantification. This work presents, for the first time, diosmin voltammetric behavior and quantification on the [...] Read more.
Diosmin (DIO) is a naturally occurring flavonoid with multiple beneficial effects on human health. The presence of different hydroxyl groups in diosmin structure enables its electrochemical investigation and quantification. This work presents, for the first time, diosmin voltammetric behavior and quantification on the cost-effective, disposable pencil graphite electrode (PGE). Diosmin oxidation on PGE involves two irreversible steps, generating products with reversible redox behaviors. All electrode processes are pH-dependent and predominantly adsorption-controlled. Differential pulse (DPV) and adsorptive stripping differential pulse (AdSDPV) voltammetric methods have been optimized for diosmin quantification o an H-type PGE, in 0.100 mol/L H2SO4. The linear ranges and limits of detection were for DPV 1.00 × 10−6–1.00 × 10−5 mol/L and 2.76 × 10−7 mol/L DIO for DPV and 1.00 × 10−7–2.50 × 10−6 mol/L and 7.42 × 10−8 mol/L DIO for AdSDPV, respectively. The DPV method was successfully applied for diosmin quantification in dietary supplement tablets. The percentage recovery was 99.87 ± 4.88%. Full article
(This article belongs to the Special Issue Electrochemical Sensors in Biological Applications)
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18 pages, 4311 KiB  
Article
Electrochemical Sensor for Determination of Various Phenolic Compounds in Wine Samples Using Fe3O4 Nanoparticles Modified Carbon Paste Electrode
by Pwadubashiyi C. Pwavodi, Vasfiye H. Ozyurt, Suleyman Asir and Mehmet Ozsoz
Micromachines 2021, 12(3), 312; https://doi.org/10.3390/mi12030312 - 17 Mar 2021
Cited by 39 | Viewed by 3475
Abstract
Phenolic compounds contain classes of flavonoids and non-flavonoids, which occur naturally as secondary metabolites in plants. These compounds, when consumed in food substances, improve human health because of their antioxidant properties against oxidative damage diseases. In this study, an electrochemical sensor was developed [...] Read more.
Phenolic compounds contain classes of flavonoids and non-flavonoids, which occur naturally as secondary metabolites in plants. These compounds, when consumed in food substances, improve human health because of their antioxidant properties against oxidative damage diseases. In this study, an electrochemical sensor was developed using a carbon paste electrode (CPE) modified with Fe3O4 nanoparticles (MCPE) for the electrosensitive determination of sinapic acid, syringic acid, and rutin. The characterization techniques adapted for CPE, MCPE electrodes, and the solution interface were cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). Scan rate and pH were the parameters subjected to optimization studies for the determination of phenolic compounds. The incorporation of Fe3O4 nanoparticles to the CPE as a sensor showed excellent sensitivity, selectivity, repeatability, reproducibility, stability, and low preparation cost. The limits of detection (LOD) obtained were 2.2 × 10−7 M for sinapic acid, 2.6 × 10−7 M for syringic acid, and 0.8 × 10−7 M for rutin, respectively. The fabricated electrochemical sensor was applied to determine phenolic compounds in real samples of red and white wine. Full article
(This article belongs to the Special Issue Electrochemical Sensors in Biological Applications)
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Review

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14 pages, 1597 KiB  
Review
Electrochemical Cell-Based Sensor for Detection of Food Hazards
by Jiancheng Zhang, Lixia Lu, Zhenguo Zhang and Liguo Zang
Micromachines 2021, 12(7), 837; https://doi.org/10.3390/mi12070837 - 18 Jul 2021
Cited by 9 | Viewed by 3341
Abstract
People’s health has been threatened by several common food hazards. Thus, it is very important to establish rapid and accurate methods to detect food hazards. In recent years, biosensors have inspired developments because of their specificity and sensitivity, short reaction time, low cost, [...] Read more.
People’s health has been threatened by several common food hazards. Thus, it is very important to establish rapid and accurate methods to detect food hazards. In recent years, biosensors have inspired developments because of their specificity and sensitivity, short reaction time, low cost, small size and easy operation. Owing to their high precision and non-destructive characteristics, cell-based electrochemical detection methods can reflect the damage of food hazards to organisms better. In this review, the characteristics of electrochemical cell-based biosensors and their applications in the detection of common hazards in food are reviewed. The strategies of cell immobilization and 3D culture on electrodes are discussed. The current limitations and further development prospects of cell-based electrochemical biosensors are also evaluated. Full article
(This article belongs to the Special Issue Electrochemical Sensors in Biological Applications)
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