Flexible and Wearable Electronics for Biomedical Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 597

Special Issue Editor


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Guest Editor
2020 X-Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China
Interests: micro/nano sensing; neural engineering; nanophotonics; intelligent bioelectronics
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Special Issue Information

Dear Colleagues,

Flexible and wearable electronics are revolutionizing biomedical applications with their adaptability, lightweight design, and biocompatibility. These advancements enable the real-time health monitoring, personalized therapeutic interventions, and improved integration of electronics with the human body. Non-invasive wearable devices, such as ultra-thin sensors, have made significant progress in real-time physiological monitoring, offering comfort, precision, and long-term usability for applications like health management and chronic disease monitoring. Meanwhile, implantable flexible devices, including ultra-flexible neural probes, achieve high-fidelity neural recording and precise therapeutic delivery in dynamic physiological environments, advancing fields like neuroprosthetics, rehabilitation, and brain–computer interfaces, further advancing personalized medicine. Despite these achievements, challenges remain, such as ensuring mechanical durability, seamless wireless transmission, and long-term stability in biological systems. Addressing these issues requires interdisciplinary collaboration and innovative approaches.

This Special Issue invites research papers, communications, and review articles addressing advancements in flexible and wearable electronics for biomedical applications. Submissions focusing on material breakthroughs, device development, and translational research are encouraged to showcase the future of intelligent bioelectronics.

Dr. Liuyang Sun
Guest Editor

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Keywords

  • flexible electronics
  • wearable electronics
  • wearable health monitoring
  • implantable sensors and actuators
  • biocompatible materials
  • real-time physiological monitoring
  • rehabilitation devices
  • human–machine interaction
  • brain–computer interface
  • wireless transmission in biomedical systems

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Published Papers (1 paper)

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Research

18 pages, 3109 KiB  
Article
Flexible Deep-Brain Probe for High-Fidelity Multi-Scale Recording of Epileptic Network Dynamics
by Dujuan Zou, Lirui Yang, Guopei Zhou, Yan Zhang, Zhenyu Liang, Ziyi Zhu, Yanyan Nie, Huiran Yang, Zhitao Zhou, Liuyang Sun and Xiaoling Wei
Micromachines 2025, 16(6), 661; https://doi.org/10.3390/mi16060661 - 30 May 2025
Viewed by 431
Abstract
Epilepsy is a complex neurological disorder characterized by abnormal neural synchronization and interactions between local foci and global brain networks during seizures. Understanding seizure mechanisms across multiple scales is essential for advancing our understanding of epileptic network dynamics and guiding personalized treatment strategies. [...] Read more.
Epilepsy is a complex neurological disorder characterized by abnormal neural synchronization and interactions between local foci and global brain networks during seizures. Understanding seizure mechanisms across multiple scales is essential for advancing our understanding of epileptic network dynamics and guiding personalized treatment strategies. However, neural recording technologies are limited by insufficient spatial resolution, signal fidelity, and the inability to simultaneously capture network- and cellular-level dynamics. To address these limitations, we developed a high-density, flexible deep-brain probe with excellent mechanical compliance and wideband recording capabilities, enabling high-fidelity recordings of high-frequency oscillations (HFOs, 80–500 Hz) and action potentials (APs). Using a pentylenetetrazol (PTZ)-induced epilepsy model, we identified distinct spatiotemporal dynamics of HFOs and APs across epileptic stages, indicating that CA3 plays a key role in seizure onset, while CA1 is crucial for propagation. AP-HFO coupling analysis further uncovered neuronal heterogeneity, offering insights into the diverse roles of neurons in epileptic networks. This study highlights the potential of a flexible deep-brain probe for advancing epilepsy research and guiding personalized therapeutic interventions. Full article
(This article belongs to the Special Issue Flexible and Wearable Electronics for Biomedical Applications)
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