Special Issue "Microfluidic-Based Approaches for Detection in Water and Food Samples"

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Dr. Lung-Ming Fu
E-Mail Website
Guest Editor
Department of Engineering Science, National Cheng Kung University, No. 1, University Road, Tainan City 701, Taiwan
Interests: microfluidics; lab on a chip; biosensors; microfluidic paper-based devices and applications
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidic technology deals with fluid flows in the geometries of micro scales. New phenomena unique to these small scales bring exciting research interests and have also entered the age of applications in the past few years. Recently, in the field of food safety and water quality detection, many microfluidic devices have been developed and applied. In this Special Issue, we invite contributions to report the state-of-the-art developments and applications of microfluidic-based approaches for detection in water and food samples, including, but not limited to, sample pretreatment and detection methods. Microfluidic-based devices may also include microfluidic chips, microfluidic paper-based devices, lab-on-a-chip, lab-on-paper, paper-strips, point-of-care devices, etc. Practical devices that demonstrate capabilities to solve real-world problems are of particular interest.

Prof. Dr. Lung-Ming Fu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Microfluidics
  • Lab-on-a-chip
  • Lab-on-paper
  • Food
  • Water

Published Papers (3 papers)

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Research

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Article
A Microfluidic Aptamer-Based Sensor for Detection of Mercury(II) and Lead(II) Ions in Water
Micromachines 2021, 12(11), 1283; https://doi.org/10.3390/mi12111283 - 21 Oct 2021
Viewed by 242
Abstract
Heavy metal contaminants have serious consequences for the environment and human health. Consequently, effective methods for detecting their presence, particularly in water and food, are urgently required. Accordingly, the present study proposes a sensor capable of detecting mercury Hg(II) and lead Pb(II) ions [...] Read more.
Heavy metal contaminants have serious consequences for the environment and human health. Consequently, effective methods for detecting their presence, particularly in water and food, are urgently required. Accordingly, the present study proposes a sensor capable of detecting mercury Hg(II) and lead Pb(II) ions simultaneously, using graphene oxide (GO) as a quenching agent and an aptamer solution as a reagent. In the proposed device, the aptamer sequences are labeled by FAM and HEX fluorescent dyes, respectively, and are mixed well with 500 ppm GO solution before injection into one inlet of the microchannel, and the heavy metal sample solution is injected into another inlet. The presence of Hg(II) and Pb(II) ions is then detected by measuring the change in the fluorescence intensity of the GO/aptamer suspension as the aptamer molecules undergo fluorescence resonance energy transfer (FRET). The selectivity of these two ions is also shown to be clear among other mixed heavy metal ions. The experimental results show that the aptamer sensors have a linear range of 10~250 nM (i.e., 2.0~50 ppb) for Hg(II) ions and 10~100 nM (i.e., 2.1~20.7 ppb) for Pb(II) ions. Furthermore, the limit of detection is around 0.70 ppb and 0.53 ppb for Hg(II) and Pb(II), respectively, which is lower than the maximum limits of 6 ppb and 10 ppb prescribed by the World Health Organization (WHO) for Hg(II) and Pb(II) in drinking water, respectively. Full article
(This article belongs to the Special Issue Microfluidic-Based Approaches for Detection in Water and Food Samples)
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Article
Process Optimization of Silver Nanoparticle Synthesis and Its Application in Mercury Detection
Micromachines 2021, 12(9), 1123; https://doi.org/10.3390/mi12091123 - 18 Sep 2021
Viewed by 562
Abstract
Silver nanoparticles (AgNPs) have stable reactivity and excellent optical absorption properties. They can be applied in various industries, such as environmental protection, biochemical engineering, and analyte monitoring. However, synthesizing AgNPs and determining their appropriate dosage as a coloring substance are difficult tasks. In [...] Read more.
Silver nanoparticles (AgNPs) have stable reactivity and excellent optical absorption properties. They can be applied in various industries, such as environmental protection, biochemical engineering, and analyte monitoring. However, synthesizing AgNPs and determining their appropriate dosage as a coloring substance are difficult tasks. In this study, to optimize the process of AgNP synthesis and obtain a simple detection method for trace mercury in the environment, we evaluate several factors—including the reagent addition sequence, reaction temperature, reaction time, the pH of the solution, and reagent concentration—considering the color intensity and purity of AgNPs as the reaction optimization criteria. The optimal process for AgNP synthesis is as follows: Mix 10 mM of silver nitrate with trisodium citrate in a hot water bath for 10 min; then, add 10 mM of sodium borohydride to produce the AgNPs and keep stirring for 2 h; finally, adjust the pH to 12 to obtain the most stable products. For AgNP-based mercury detection, the calibration curve of mercury over the concentration range of 0.1–2 ppb exhibits good linearity (R2 > 0.99). This study provides a stable and excellent AgNP synthesis technique that can improve various applications involving AgNP-mediated reactions and has the potential to be developed as an alternative to using expensive detection equipment and to be applied for the detection of mercury in food. Full article
(This article belongs to the Special Issue Microfluidic-Based Approaches for Detection in Water and Food Samples)
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Review

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Review
Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk
Micromachines 2021, 12(5), 558; https://doi.org/10.3390/mi12050558 - 14 May 2021
Cited by 4 | Viewed by 1049
Abstract
Milk is a necessity for human life. However, it is susceptible to contamination and adulteration. Microfluidic analysis devices have attracted significant attention for the high-throughput quality inspection and contaminant analysis of milk samples in recent years. This review describes the major proposals presented [...] Read more.
Milk is a necessity for human life. However, it is susceptible to contamination and adulteration. Microfluidic analysis devices have attracted significant attention for the high-throughput quality inspection and contaminant analysis of milk samples in recent years. This review describes the major proposals presented in the literature for the pretreatment, contaminant detection, and quality inspection of milk samples using microfluidic lab-on-a-chip and lab-on-paper platforms in the past five years. The review focuses on the sample separation, sample extraction, and sample preconcentration/amplification steps of the pretreatment process and the determination of aflatoxins, antibiotics, drugs, melamine, and foodborne pathogens in the detection process. Recent proposals for the general quality inspection of milk samples, including the viscosity and presence of adulteration, are also discussed. The review concludes with a brief perspective on the challenges facing the future development of microfluidic devices for the analysis of milk samples in the coming years. Full article
(This article belongs to the Special Issue Microfluidic-Based Approaches for Detection in Water and Food Samples)
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