Bio-MEMS for Brain Research

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2268

Special Issue Editor


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Enhanced Regenerative Medicine, Istituto Italiano di Tecnologia, 16163 Genova, Italy
Interests: epilepsy; brain regeneration; biohybrid systems; closed-loop neuroprostheses
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Special Issue Information

Dear Colleagues,

Micro-electro-mechanical systems for biomedical applications (bio-MEMS) are today the core enabling technology for high-throughput fundamental and translational brain research. Over the past decades, advancements in microfabrication techniques have enabled multi-modal bio-MEMS platforms incorporating diverse functionalities to simultaneously address the multiple facets of brain function in health and disease: these include biosensors, microfluidics-assisted drug delivery systems, and components for electrical and optical stimulation to probe and modulate neural function. While bio-MEMS for brain research are most known for their use in brain-on-chip biotechnology, their deployment has more recently been extended to biohybrid brain-implantable devices, wherein the cellular component can improve the brain–device coupling, support the functional repair of compromised brain circuits, or act as a biological delivery system for biomolecules. Owing to the virtually infinite potential applications of bio-MEMS, there is an increasing demand for novel systems to advance fundamental and translational studies spanning from in vitro to in vivo applications. In this Special Issue, we invite submissions addressing the use of bio-MEMS for brain research, aiming to advance their state of the art and applications in fundamental and translational studies. Potential topics include, but are not limited to, the following: multi-modal brain-on-chip platforms; biohybrid MEMS devices for brain function modulation and repair; microfabrication techniques for novel or improved bio-MEMS functionality; novel microfabrication techniques and materials for flexible/soft bio-MEMS; MEMS devices for improved axon and neural circuit topology guidance; bio-MEMS to study the interaction between neurons and non-neuronal cells.

Dr. Gabriella Panuccio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Dr. Gabriella Panuccio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bio-MEMS
  • brain-on-chip
  • biohybrid systems
  • multi-modal platforms
  • neurons
  • non-neuronal cells

Published Papers (1 paper)

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Research

17 pages, 1697 KiB  
Article
Microfluidic Bi-Layer Platform to Study Functional Interaction between Co-Cultured Neural Networks with Unidirectional Synaptic Connectivity
by Yana Pigareva, Arseniy Gladkov, Vladimir Kolpakov, Anton Bukatin, Sergei Li, Victor B. Kazantsev, Irina Mukhina and Alexey Pimashkin
Micromachines 2023, 14(4), 835; https://doi.org/10.3390/mi14040835 - 11 Apr 2023
Cited by 1 | Viewed by 1993
Abstract
The complex synaptic connectivity architecture of neuronal networks underlies cognition and brain function. However, studying the spiking activity propagation and processing in heterogeneous networks in vivo poses significant challenges. In this study, we present a novel two-layer PDMS chip that facilitates the culturing [...] Read more.
The complex synaptic connectivity architecture of neuronal networks underlies cognition and brain function. However, studying the spiking activity propagation and processing in heterogeneous networks in vivo poses significant challenges. In this study, we present a novel two-layer PDMS chip that facilitates the culturing and examination of the functional interaction of two interconnected neural networks. We utilized cultures of hippocampal neurons grown in a two-chamber microfluidic chip combined with a microelectrode array. The asymmetric configuration of the microchannels between the chambers ensured the growth of axons predominantly in one direction from the Source chamber to the Target chamber, forming two neuronal networks with unidirectional synaptic connectivity. We showed that the local application of tetrodotoxin (TTX) to the Source network did not alter the spiking rate in the Target network. The results indicate that stable network activity in the Target network was maintained for at least 1–3 h after TTX application, demonstrating the feasibility of local chemical activity modulation and the influence of electrical activity from one network on the other. Additionally, suppression of synaptic activity in the Source network by the application of CPP and CNQX reorganized spatio-temporal characteristics of spontaneous and stimulus-evoked spiking activity in the Target network. The proposed methodology and results provide a more in-depth examination of the network-level functional interaction between neural circuits with heterogeneous synaptic connectivity. Full article
(This article belongs to the Special Issue Bio-MEMS for Brain Research)
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