Nonlinear Optics for Biomedical Applications

A special issue of Micromachines (ISSN 2072-666X).

Deadline for manuscript submissions: closed (17 June 2019) | Viewed by 3051

Special Issue Editor


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Guest Editor
Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
Interests: optical tweezers; biomaterials; nonlinear optics; scanning probe microscopy

Special Issue Information

Dear Colleagues,

The centuries old relationship of optics with biomedical sciences and engineering was considerably expanded in 1960, with the invention of the laser and the resulting practical availability of nonlinear optical effects. In the decades since then, nonlinear optics have been commonly involved with microscopy, spectroscopy, and sensing, as well as the convenient generation of new wavelengths of light for optical imaging and therapies.

In this Special Issue of Micromachines, we highlight the contributions made by nonlinear optics in the development of microscale sensors and actuators for biomedical applications. Areas of interest include, but are not limited to, applications of optical tweezers, multiphoton lithographic fabrication of microfluidics and microdevices, the fabrication of structured surfaces for cell culture, and fiber-based nonlinear microscopy.

Prof. Mark Cronin-Golomb
Guest Editor

Manuscript Submission Information

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Keywords

  • Imaging in tissue
  • Raman spectroscopy and microscopy
  • Nonlinear microscopy
  • Optical sources for imaging and therapy
  • Microfabrication
  • Optical tweezers

Published Papers (1 paper)

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Research

12 pages, 3025 KiB  
Article
Multimodal Nonlinear Microscopy for Therapy Monitoring of Cold Atmospheric Plasma Treatment
by Tobias Meyer, Hyeonsoo Bae, Sybille Hasse, Jörn Winter, Thomas von Woedtke, Michael Schmitt, Klaus-Dieter Weltmann and Juergen Popp
Micromachines 2019, 10(9), 564; https://doi.org/10.3390/mi10090564 - 26 Aug 2019
Cited by 5 | Viewed by 2655
Abstract
Here we report on a non-linear spectroscopic method for visualization of cold atmospheric plasma (CAP)-induced changes in tissue for reaching a new quality level of CAP application in medicine via online monitoring of wound or cancer treatment. A combination of coherent anti-Stokes Raman [...] Read more.
Here we report on a non-linear spectroscopic method for visualization of cold atmospheric plasma (CAP)-induced changes in tissue for reaching a new quality level of CAP application in medicine via online monitoring of wound or cancer treatment. A combination of coherent anti-Stokes Raman scattering (CARS), two-photon fluorescence lifetime imaging (2P-FLIM) and second harmonic generation (SHG) microscopy has been used for non-invasive and label-free detection of CAP-induced changes on human skin and mucosa samples. By correlation with histochemical staining, the observed local increase in fluorescence could be assigned to melanin. CARS and SHG prove the integrity of the tissue structure, visualize tissue morphology and composition. The influence of plasma effects by variation of plasma parameters e.g., duration of treatment, gas composition and plasma source has been evaluated. Overall quantitative spectroscopic markers could be identified for a direct monitoring of CAP-treated tissue areas, which is very important for translating CAPs into clinical routine. Full article
(This article belongs to the Special Issue Nonlinear Optics for Biomedical Applications)
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