Special Issue "Nanostructured Surfaces and Devices for Biomedical Applications"

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editors

Dr. Valentina Mussi
E-Mail Website
Guest Editor
IMM CNR, Institute of Microelectronics and Microsystems, National Research Council, 00133 Rome, Italy
Interests: Raman microscopy; biosensing; nanostructures
Dr. Annalisa Convertino
E-Mail Website
Guest Editor
IMM CNR, Institute of Microelectronics and Microsystems, National Research Council, 00133 Rome, Italy
Interests: material science; nanotechnology; biosensing
Dr. Antonella Lisi
E-Mail Website
Guest Editor
IFT CNR, Institute of Translational Pharmacology, National Research Council, 00133 Rome, Italy
Interests: regenerative medicine; cell therapy; nano-biotechnology; biomaterials

Special Issue Information

Dear Colleagues,

The ability to control and modify the surface topography of materials at the nanoscale, which is producing features with a comparable size to that of biological entities, has opened the way to incredible application possibilities in the fields of biomedicine, biosensing, and diagnostics.

Extraordinary achievements have been obtained in cell investigation and manipulation by realizing scaffolds and biodegradable structures that can mimic micro and nanoscale natural tissue organization for regenerative purposes, or to influence, stimulate, and orient cell migration and differentiation, while bioinspired randomly oriented anisotropic nanostructures inserted in microfluidic devices have demonstrated notable topography-based capturing capabilities for molecular monitoring and low-concentration marker recognition in biological fluids.

On the other end, the nanostructuring of surfaces and interfaces can also alter and adjust their mechanical and “active properties”, such as optical, thermal, and electrical ones, to realize multifunctional platforms combining imaging, diagnostic, and therapeutic capabilities.

Accordingly, this Special Issue is devoted to collecting research papers, short communications, and review articles dedicated to innovative and advanced properties and applications of nanostructured surfaces and more complex devices, trying to foresee the future of biomedicine, right at the interface between different but converging disciplines.

Dr. Valentina Mussi
Dr. Annalisa Convertino
Dr. Antonella Lisi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biosensors
  • nanostructured surfaces and interfaces
  • micro and nanofluidics
  • lab-on-chip
  • cell- and organ-on-a-chip
  • regenerative medicine
  • diagnostics
  • bioanalytics
  • therapeutics
  • personalized medicine

Published Papers (4 papers)

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Research

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Article
Raman Mapping of Biological Systems Interacting with a Disordered Nanostructured Surface: A Simple and Powerful Approach to the Label-Free Analysis of Single DNA Bases
Micromachines 2021, 12(3), 264; https://doi.org/10.3390/mi12030264 - 04 Mar 2021
Viewed by 514
Abstract
This article demonstrates the possibility to use a novel powerful approach based on Raman mapping of analyte solutions drop casted on a disordered array of Ag covered silicon nanowires (Ag/SiNWs), to identify the characteristic spectral signal of the four DNA bases, adenine (A), [...] Read more.
This article demonstrates the possibility to use a novel powerful approach based on Raman mapping of analyte solutions drop casted on a disordered array of Ag covered silicon nanowires (Ag/SiNWs), to identify the characteristic spectral signal of the four DNA bases, adenine (A), thymine (T), cytosine (C), and guanine (G), at concentration as low as 10 ng/µL, and to study their specific way of interacting with the nanostructured substrate. The results show a distinctive and amplified interaction of guanine, the base that is most susceptible to oxidation, with the nanostructured surface. Our findings explain the recently revealed diverse behaviour of cancer and normal DNA deposited on the same Ag/SiNWs, which is ascribed to mechanical deformation and base lesions present on the oxidised DNA molecule backbone and causes detectable variation in the Raman signal, usable for diagnostic purposes. The notable bio-analytical capability of the presented platform, and its sensitivity to the molecule mechanical conformation at the single-base level, thus provides a new reliable, rapid, label-free DNA diagnostic methodology alternative to more sophisticated and expensive sequencing ones. Full article
(This article belongs to the Special Issue Nanostructured Surfaces and Devices for Biomedical Applications)
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Article
Bacillus thuringiensis Cells Selectively Captured by Phages and Identified by Surface Enhanced Raman Spectroscopy Technique
Micromachines 2021, 12(2), 100; https://doi.org/10.3390/mi12020100 - 20 Jan 2021
Cited by 2 | Viewed by 544
Abstract
In this work, the results on the detection and identification of Bacillus thuringiensis (Bt) cells by using surface-enhanced Raman spectroscopy (SERS) are presented. Bt has been chosen as a harmless surrogate of the pathogen Bacillus anthracis (Ba) responsible for [...] Read more.
In this work, the results on the detection and identification of Bacillus thuringiensis (Bt) cells by using surface-enhanced Raman spectroscopy (SERS) are presented. Bt has been chosen as a harmless surrogate of the pathogen Bacillus anthracis (Ba) responsible for the deadly Anthrax disease, because of their genetic similarities. Drops of 200 μL of Bt suspensions, with concentrations 102 CFU/mL, 104 CFU/mL, 106 CFU/mL, were deposited on a SERS chip and sampled after water evaporation. To minimize the contribution to the SERS data given by naturally occurring interferents present in a real scenario, the SERS chip was functionalized with specific phage receptors BtCS33, that bind Bt (or Ba) cells to the SERS surface and allow to rinse the chip removing unwanted contaminants. Different chemometric approaches were applied to the SERS data to classify spectra from Bt-contaminated and uncontaminated areas of the chip: Principal Component Regression (PCR), Partial Least Squares Regression (PLSR) and Data Driven Soft Independent Modeling of Class Analogy (DD-SIMCA). The first two was tested and trained by using data from both contaminated and un-contaminated chips, the last was trained by using data from un-contaminated chips only and tested with all the available data. All of them were able to correctly classify the SERS spectra with great accuracy, the last being suitable for an automated recognition procedure. Full article
(This article belongs to the Special Issue Nanostructured Surfaces and Devices for Biomedical Applications)
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Review

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Review
Extrinsically Conductive Nanomaterials for Cardiac Tissue Engineering Applications
Micromachines 2021, 12(8), 914; https://doi.org/10.3390/mi12080914 - 31 Jul 2021
Viewed by 544
Abstract
Myocardial infarction (MI) is the consequence of coronary artery thrombosis resulting in ischemia and necrosis of the myocardium. As a result, billions of contractile cardiomyocytes are lost with poor innate regeneration capability. This degenerated tissue is replaced by collagen-rich fibrotic scar tissue as [...] Read more.
Myocardial infarction (MI) is the consequence of coronary artery thrombosis resulting in ischemia and necrosis of the myocardium. As a result, billions of contractile cardiomyocytes are lost with poor innate regeneration capability. This degenerated tissue is replaced by collagen-rich fibrotic scar tissue as the usual body response to quickly repair the injury. The non-conductive nature of this tissue results in arrhythmias and asynchronous beating leading to total heart failure in the long run due to ventricular remodelling. Traditional pharmacological and assistive device approaches have failed to meet the utmost need for tissue regeneration to repair MI injuries. Engineered heart tissues (EHTs) seem promising alternatives, but their non-conductive nature could not resolve problems such as arrhythmias and asynchronous beating for long term in-vivo applications. The ability of nanotechnology to mimic the nano-bioarchitecture of the extracellular matrix and the potential of cardiac tissue engineering to engineer heart-like tissues makes it a unique combination to develop conductive constructs. Biomaterials blended with conductive nanomaterials could yield conductive constructs (referred to as extrinsically conductive). These cell-laden conductive constructs can alleviate cardiac functions when implanted in-vivo. A succinct review of the most promising applications of nanomaterials in cardiac tissue engineering to repair MI injuries is presented with a focus on extrinsically conductive nanomaterials. Full article
(This article belongs to the Special Issue Nanostructured Surfaces and Devices for Biomedical Applications)
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Review
Nanopatterning with Photonic Nanojets: Review and Perspectives in Biomedical Research
Micromachines 2021, 12(3), 256; https://doi.org/10.3390/mi12030256 - 03 Mar 2021
Cited by 3 | Viewed by 891
Abstract
Nanostructured surfaces and devices offer astounding possibilities for biomedical research, including cellular and molecular biology, diagnostics, and therapeutics. However, the wide implementation of these systems is currently limited by the lack of cost-effective and easy-to-use nanopatterning tools. A promising solution is to use [...] Read more.
Nanostructured surfaces and devices offer astounding possibilities for biomedical research, including cellular and molecular biology, diagnostics, and therapeutics. However, the wide implementation of these systems is currently limited by the lack of cost-effective and easy-to-use nanopatterning tools. A promising solution is to use optical methods based on photonic nanojets, namely, needle-like beams featuring a nanometric width. In this review, we survey the physics, engineering strategies, and recent implementations of photonic nanojets for high-throughput generation of arbitrary nanopatterns, along with applications in optics, electronics, mechanics, and biosensing. An outlook of the potential impact of nanopatterning technologies based on photonic nanojets in several relevant biomedical areas is also provided. Full article
(This article belongs to the Special Issue Nanostructured Surfaces and Devices for Biomedical Applications)
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