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Special Issue Editor

Prof. Dr. Yiqiang Fan

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Guest Editor

School of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Interests: manufacturing of microfluidic systems; microfluidic technology with life sciences and analytical chemistry

Special Issue Information

Dear Colleagues,

The integration of microtechnology in medical fields enables precise sensing, surgical operation, and drug delivery at the microscale. With the help of MEMS (micro-electro-mechanical systems) and microfabrication technology, microtechnology has had a significant impact on current medical applications: implantable microsensors can transfer signals in vivo from targeting tissue or blood vessels, microdevices can perform tissue gripping and cutting at microscale, and microfluidic systems enable wrapping and precision drug delivery. This Special Issue seeks to publish cutting-edge microtechnology in medical applications, including but not limited to MEMS biosensors, the novel design of microdevices for surgical applications, neural probes, and precise drug-delivery approaches with microdevices.

Prof. Dr. Yiqiang Fan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

MEMS
microfluidics
tissue handling
microgripping
nanoscale manipulation
microscale sensing
neural probes
surgical devices
drug delivery

Published Papers (2 papers)

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Research

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18 pages, 2343 KiB

Open AccessArticle

Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer’s, and Enzyme Inhibition Potential

by Sania Zafar, Shah Faisal, Hasnain Jan, Riaz Ullah, Muhammad Rizwan, Abdullah, Amal Alotaibi, Nadia Bibi, Amin Ur Rashid and Aishma Khattak

Micromachines 2022, 13(8), 1259; https://doi.org/10.3390/mi13081259 - 5 Aug 2022

Cited by 25 | Viewed by 2186

Abstract

Nanotechnology is a new field that has gained considerable importance due to its potential uses in the field of biosciences, medicine, engineering, etc. In the present study, bio-inspired metallic iron nanoparticles (FeNPs) were prepared using biomass of Enterobacter train G52. The prepared particles were characterized by UV-spectroscopy, TGA, XRD, SEM, EDX, and FTIR techniques. The crystalline nature of the prepared FeNPs was confirmed by XRD. The SEM techniques revealed the particles size to be 23 nm, whereas in FTIR spectra the peaks in the functional group region indicated the involvement of bioactive compounds of selected bacterial strains in the capping of FeNPs. The EDX confirmed the presence of iron in the engineered FeNPs. The FeNPs were then evaluated for its antibacterial, antifungal, antioxidant, anti-inflammatory, anti-Alzheimer’s, anti-larvicidal, protein kinase inhibition, anti-diabetic, and biocompatibility potentials using standard protocols. Substantial activities were observed in almost all biological assays used. The antioxidant, anti-cholinesterase, and anti-diabetic potential of the prepared nanoparticles were high in comparison to other areas of biological potential, indicating that the FeNPs are capable of targeting meditators of oxidative stress leading to diabetes and Alzheimer’s disease. However, the claim made needs some further experimentation to confirm the observed potential in in vivo animal models. Full article

(This article belongs to the Special Issue Cutting-Edge Microtechnology in Medical Applications)

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Review

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21 pages, 4887 KiB

Open AccessReview

Protein Albumin Manipulation and Electrical Quantification of Molecular Dielectrophoresis Responses for Biomedical Applications

by Nur Shahira Abdul Nasir, Revathy Deivasigamani, M. F. Mohd Razip Wee, Azrul Azlan Hamzah, Mohd Hazani Mat Zaid, Muhammad Khairulanwar Abdul Rahim, Aminuddin Ahmad Kayani, Abdullah Abdulhameed and Muhamad Ramdzan Buyong

Micromachines 2022, 13(8), 1308; https://doi.org/10.3390/mi13081308 - 13 Aug 2022

Cited by 3 | Viewed by 1867

Abstract

Research relating to dielectrophoresis (DEP) has been progressing rapidly through time as it is a strong and controllable technique for manipulation, separation, preconcentration, and partitioning of protein. Extensive studies have been carried out on protein DEP, especially on Bovine Serum Albumin (BSA). However, these studies involve the usage of dye and fluorescent probes to observe DEP responses as the physical properties of protein albumin molecular structure are translucent. The use of dye and the fluorescent probe could later affect the protein’s physiology. In this article, we review three methods of electrical quantification of DEP responses: electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and capacitance measurement for protein BSA DEP manipulation. The correlation of these methods with DEP responses is further discussed. Based on the observations on capacitance measurement, it can be deduced that the electrical quantifying method is reliable for identifying DEP responses. Further, the possibility of manipulating the protein and electrically quantifying DEP responses while retaining the original physiology of the protein and without the usage of dye or fluorescent probe is discussed. Full article

(This article belongs to the Special Issue Cutting-Edge Microtechnology in Medical Applications)

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