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Micromachines
Special Issues
Microfluidics for Health Monitoring
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Microfluidics for Health Monitoring

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 3922

Special Issue Editor

Dr. Haisong Lin

E-Mail Website
Guest Editor
Department of Mechanical Engineering, The University of Hong Kong, Hong Kong 999077, China
Interests: microfluidics; wearable devices; biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past 30 years, microfluidics has become a fundamental tool that is widely deployed in multidisciplinary fields, such as biology, chemistry, physics, and engineering. Among a variety of its applications, one of the most important aspects is health monitoring, which drew extra attention and proved to be directly beneficial to our daily lives during the COVID-19 pandemic. With the recent maturity and convergence of microfluidic related technologies, in terms of micro-device fabrication, biosensing, low power electronics, and internet of things, future health monitoring microfluidic devices may potentially accelerate the decentralization process of diagnostics from hospitals and clinics to homes and workplaces, where the microfluidic devices can greatly improve the accessibility of medical diagnostics and enable longitudinal and objective assessment of the health status of individuals in daily life. Accordingly, this Special Issue aims to highlight research papers, short communications, and review articles that focus on: (1) novel microfluidic design and fabrication techniques and (2) micro-total analysis system (µTAS) that can be applied for health monitoring. 

We look forward to receiving your submissions!

Dr. Haisong Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics for Point-of-Care testing (POCT) and In Vitro Diagnostics (IVD)
  • microfluidics for biomarkers monitoring
  • novel microfluidic fabrication techniques
  • novel microfluidic systems
    • wearable microfluidics
    • digital microfluidics
    • centrifugal microfluidics
    • paper based microfluidics
    • other

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Published Papers (2 papers)

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Research

16 pages, 3354 KiB  
Article
Magnetophoresis in Centrifugal Microfluidics at Continuous Rotation for Nucleic Acid Extraction
by Sebastian Hin, Nils Paust, Markus Rombach, Jan Lüddecke, Mara Specht, Roland Zengerle and Konstantinos Mitsakakis
Micromachines 2022, 13(12), 2112; https://doi.org/10.3390/mi13122112 - 29 Nov 2022
Cited by 2 | Viewed by 1864
Abstract
Centrifugal microfluidics enables fully automated molecular diagnostics at the point-of-need. However, the integration of solid-phase nucleic acid extraction remains a challenge. Under this scope, we developed the magnetophoresis under continuous rotation for magnetic bead-based nucleic acid extraction. Four stationary permanent magnets are arranged [...] Read more.
Centrifugal microfluidics enables fully automated molecular diagnostics at the point-of-need. However, the integration of solid-phase nucleic acid extraction remains a challenge. Under this scope, we developed the magnetophoresis under continuous rotation for magnetic bead-based nucleic acid extraction. Four stationary permanent magnets are arranged above a cartridge, creating a magnetic field that enables the beads to be transported between the chambers of the extraction module under continuous rotation. The centrifugal force is maintained to avoid uncontrolled spreading of liquids. We concluded that below a frequency of 5 Hz, magnetic beads move radially inwards. In support of magnetophoresis, bead inertia and passive geometrical design features allow to control the azimuthal bead movement between chambers. We then demonstrated ferrimagnetic bead transfer in liquids with broad range of surface tension and density values. Furthermore, we extracted nucleic acids from lysed Anopheles gambiae mosquitoes reaching comparable results of eluate purity (LabDisk: A260/A280 = 1.6 ± 0.04; Reference: 1.8 ± 0.17), and RT-PCR of extracted RNA (LabDisk: Ct = 17.9 ± 1.6; Reference: Ct = 19.3 ± 1.7). Conclusively, magnetophoresis at continuous rotation enables easy cartridge integration and nucleic acid extraction at the point-of-need with high yield and purity. Full article
(This article belongs to the Special Issue Microfluidics for Health Monitoring)
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14 pages, 7178 KiB  
Article
Interface Dynamics and the Influence of Gravity on Droplet Generation in a Y-microchannel
by Alexandra Bran, Nicoleta Octavia Tanase and Corneliu Balan
Micromachines 2022, 13(11), 1941; https://doi.org/10.3390/mi13111941 - 10 Nov 2022
Viewed by 1595
Abstract
The present experimental investigation is focused on the influence of gravity upon water-droplet formation in a Y-microchannel filled with oil. The flows are in the Stokes regime, with very small capillary numbers and Ohnesorge numbers less than one. The study was performed in [...] Read more.
The present experimental investigation is focused on the influence of gravity upon water-droplet formation in a Y-microchannel filled with oil. The flows are in the Stokes regime, with very small capillary numbers and Ohnesorge numbers less than one. The study was performed in a square-cross-section channel, with a = 1.0 mm as the characteristic dimension and a flow rate ratio κ in a range between 0.55 and 1.8. The interface dynamics in the vicinity of breakup and the transitory plug flow regime after the detachment of the droplet were analysed. The dependence of droplet length L was correlated with the channel position against the gravity and κ parameters. The results of the work prove that, for κ=1, the droplet length L is independent of channel orientation. Full article
(This article belongs to the Special Issue Microfluidics for Health Monitoring)
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