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Micromachines
Special Issues
Microfluidics for Healthcare Based Applications
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Microfluidics for Healthcare Based Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (15 July 2020) | Viewed by 6940

Special Issue Editor

Dr. Jungil Choi

E-Mail Website
Guest Editor
School of Mechanical Engineering Kookmin University, Seoul 02707, Korea
Interests: microfluidics; biomedical engineering; wearable sensors; organ-on-a-chip; point of care testing; implantable devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidic platforms have performed important roles in healthcare applications because they have the capability of manipulating small amounts of fluids. Biofluids such as blood, urine, tear, sweat, and saliva are performing a crucial role to support human health and contain various important biomarkers. Also, mammalian cells in the microscale are basic building blocks of the human body. And, the human body is living with various kinds of microorganism which are also on the microscale. Controlling the biofluids and cells in a precise way allows microfluidics to take an important role in healthcare. Accordingly, this Special Issue is looking for research papers, short communications, and review articles that use microfluidics for the in vitro diagnostics, point of care testing, wearable sensors, implantable device, organ on a chip and biosystems.

Dr. Jungil Choi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Point of care testing
  • In vitro diagnostics
  • Wearable sensors
  • Implantable devices
  • Drug screening
  • Organ-on-a-chip
  • Biosystems

Published Papers (2 papers)

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Research

15 pages, 5380 KiB  
Article
Integrated Immunomagnetic Bead-Based Microfluidic Chip for Exosomes Isolation
by Fuzhou Niu, Xifu Chen, Xuemei Niu, Yifan Cai, Qingkui Zhang, Tao Chen and Hao Yang
Micromachines 2020, 11(5), 503; https://doi.org/10.3390/mi11050503 - 15 May 2020
Cited by 19 | Viewed by 2995
Abstract
Exosomes are essential early biomarkers for health monitoring and cancer diagnosis. A prerequisite for further investigation of exosomes is the isolation, which is technically challenging due to the complexity of body fluids. This paper presents the development of an integrated microfluidic chip for [...] Read more.
Exosomes are essential early biomarkers for health monitoring and cancer diagnosis. A prerequisite for further investigation of exosomes is the isolation, which is technically challenging due to the complexity of body fluids. This paper presents the development of an integrated microfluidic chip for exosomes isolation, which combines the traditional immunomagnetic bead-based protocol and the recently emerging microfluidic approach, resulting in benefits from both the high-purity of the former and the automated continuous superiority of the latter. The chip was designed based on an S-shaped micromixer with embedded baffle. The excellent mixing efficiency of this micromixer compared with Y-shaped and S-shaped micromixers was verified by simulation and experiments. The photolithography technique was employed to fabricate the integrated microfluidic chip, and the manufacturing process was elucidated. We finally established an experimental platform for exosomes isolation with the fabricated microfluidic chip built in. Exosomes isolation experiments were conducted using this platform. The distribution and morphology of the isolated exosomes were observed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Quantitative size analyses based on transmission electron micrographs indicated that most of the obtained particles were between 30 and 150 nm. Western blot analyses of the isolated exosomes and the serum were conducted to verify the platform’s capability of isolating a certain subpopulation of exosomes corresponding to specified protein markers (CD63). The complete time for isolation of 150 μL serum samples was approximately 50 min, which was highly competitive with the reported existing protocols. Experimental results proved the capacity of the established integrated microfluidic chip for exosomes isolation with high purity, high integrity, and excellent efficiency. The platform can be further developed to make it possible for practical use in clinical applications as a universal exosomes isolation and characterization tool. Full article
(This article belongs to the Special Issue Microfluidics for Healthcare Based Applications)
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10 pages, 3426 KiB  
Article
Microspinning: Local Surface Mixing via Rotation of Magnetic Microparticles for Efficient Small-Volume Bioassays
by Su Deok Kim, Seo Woo Song, Dong Yoon Oh, Amos Chungwon Lee, Jeong Woo Koo, Taehun Kang, Min Chang Kim, Changhee Lee, Yunjin Jeong, Hyun Yong Jeong, Daewon Lee, Seongkyu Cho, Sunghoon Kwon and Jiyun Kim
Micromachines 2020, 11(2), 175; https://doi.org/10.3390/mi11020175 - 07 Feb 2020
Cited by 4 | Viewed by 3546
Abstract
The need for high-throughput screening has led to the miniaturization of the reaction volume of the chamber in bioassays. As the reactor gets smaller, surface tension dominates the gravitational or inertial force, and mixing efficiency decreases in small-scale reactions. Because passive mixing by [...] Read more.
The need for high-throughput screening has led to the miniaturization of the reaction volume of the chamber in bioassays. As the reactor gets smaller, surface tension dominates the gravitational or inertial force, and mixing efficiency decreases in small-scale reactions. Because passive mixing by simple diffusion in tens of microliter-scale volumes takes a long time, active mixing is needed. Here, we report an efficient micromixing method using magnetically rotating microparticles with patterned magnetization induced by magnetic nanoparticle chains. Because the microparticles have magnetization patterning due to fabrication with magnetic nanoparticle chains, the microparticles can rotate along the external rotating magnetic field, causing micromixing. We validated the reaction efficiency by comparing this micromixing method with other mixing methods such as simple diffusion and the use of a rocking shaker at various working volumes. This method has the potential to be widely utilized in suspension assay technology as an efficient mixing strategy. Full article
(This article belongs to the Special Issue Microfluidics for Healthcare Based Applications)
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