Special Issue "Microengineering Techniques for Disease Modeling and Drug Discovery, Volume II"

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editors

Dr. Mohsen Akbari
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Guest Editor
Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, Canada
Interests: microfluidics; biofabrication; tissue engineering; drug delivery; disease modeling
Special Issues and Collections in MDPI journals
Dr. Carlos Escobedo
Website
Guest Editor
Department of Chemical Engineering, Queen's University, Kingston, Canada
Interests: microfluidics; biosensing; lab-on-chip; single cell studies
Special Issues and Collections in MDPI journals

Special Issue Information

Microengineering approaches are enabling technologies for creating biomimetic cell culture systems that recapitulate cell–cell and cell–tissue interactions, as well as spatiotemporal chemical gradients and dynamic mechanical microenvironments in living organs. These bioengineered systems offer unique opportunities for disease modeling and drug discovery due to their ability to promote cellular and tissue organizations which were not possible in conventional monolayer culture systems. The current Special Issue aims to address recent advances in the fabrication and operation of microengineered tissue culture platforms with particular emphasis on microfabricated tissues, single- or multi-organ-on-chip devices, 3D bioprinted tissue models, and multicellular spheroids. The interface of these systems with genomics, metabolomics, and proteomics for the better understanding of disease formation and progression is also of great interest. Moreover, we encourage manuscripts on the development of sensors for long-term monitoring of cellular microenvironments and studies reporting high-throughput designs for investigating the toxicity of drugs and their metabolites.

Dr. Mohsen Akbari
Dr. Carlos Escobedo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Microfabrication
  • Microengineering
  • Disease modeling
  • Tissue engineering
  • Drug discovery
  • Organs-on-chip

Published Papers (1 paper)

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Review

Open AccessReview
Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip
Micromachines 2020, 11(6), 599; https://doi.org/10.3390/mi11060599 - 18 Jun 2020
Abstract
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices, known as organ-on-a-chip (OOC) platforms mimic the in vivo like microenvironment [...] Read more.
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices, known as organ-on-a-chip (OOC) platforms mimic the in vivo like microenvironment of living organs and offer more physiologically relevant in vitro models of human organs. Consequently, the concept of OOC has gained great attention from researchers in the field worldwide to offer powerful tools for biomedical researches including disease modeling, drug development, etc. This review highlights the background of biochip development. Herein, we focus on applications of LOC devices as a versatile tool for POC applications. We also review current progress in OOC platforms towards body-on-a-chip, and we provide concluding remarks and future perspectives for OOC platforms for POC applications. Full article
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