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Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip

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Institut de Génie Biomédical, Polytechnique Montréal, Montreal, QC H3C 3A7, Canada
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Department of Chemical Engineering, Polytechnique Montréal, Montreal, QC H3C 3A7, Canada
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Department of Surgery, McGill University, Montreal, QC H3G 1A4, Canada
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Injury, Repair and Recovery Program, Research Institute of McGill University Health Centre, Montreal, QC H3H 2R9, Canada
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Polystim Neurotech Laboratory, Electrical Engineering Department, Polytechnique Montreal, QC H3T 1J4, Canada
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CenBRAIN Laboratory, School of Engineering, Westlake Institute for Advanced Study, Westlake University, Hangzhou 310024, China
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NSERC-Industry Chair, CREPEC, Chemical Engineering Department, Polytechnique Montreal, Montreal, QC H3C 3A7, Canada
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Authors to whom correspondence should be addressed.
Micromachines 2020, 11(6), 599; https://doi.org/10.3390/mi11060599
Received: 2 May 2020 / Revised: 9 June 2020 / Accepted: 16 June 2020 / Published: 18 June 2020
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices, known as organ-on-a-chip (OOC) platforms mimic the in vivo like microenvironment of living organs and offer more physiologically relevant in vitro models of human organs. Consequently, the concept of OOC has gained great attention from researchers in the field worldwide to offer powerful tools for biomedical researches including disease modeling, drug development, etc. This review highlights the background of biochip development. Herein, we focus on applications of LOC devices as a versatile tool for POC applications. We also review current progress in OOC platforms towards body-on-a-chip, and we provide concluding remarks and future perspectives for OOC platforms for POC applications. View Full-Text
Keywords: organ-on-a-chip; lab-on-a-chip; microfluidics; microengineering; BioMEMS; point-of-care; personalized medicine organ-on-a-chip; lab-on-a-chip; microfluidics; microengineering; BioMEMS; point-of-care; personalized medicine
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Azizipour, N.; Avazpour, R.; Rosenzweig, D.H.; Sawan, M.; Ajji, A. Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip. Micromachines 2020, 11, 599.

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