Biosensors for Biomedical, Agricultural and Environmental Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B1: Biosensors".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 648

Special Issue Editor


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Guest Editor
Institut UTINAM, Université de Franche-Comté, CNRS, F-25000 Besançon, France
Interests: biosensors; immunosensors; electrochemistry

Special Issue Information

Dear Colleagues,

We are glad to announce a Special Issue of Micromachines focusing on "Biosensors for Biomedical, Agricultural and Environmental Applications".

Biosensors are powerful tools for detecting biomarkers, pollutants, xenobiotics, pesticides and contaminants, and their evolution can significantly improve environmental health monitoring and medical diagnostic processes.

Biosensors can be categorized depending on their sensing element, the relevant support, the transduction mechanism or their intended application. Great scientific effort has been devoted to improving and optimizing all of these aspects, aiming to enhance the selectivity and sensitivity of existing sensors while exploring routes to develop novel devices. Contributions stemming from chemistry, biology, physics, engineering, computation and medicine intertwine and complement one another, propelling research in this multidisciplinary, vibrant and dynamic field.

This Special Issue aims to provide an overview of recent advances in the design and production of novel biosensors, with a special focus on novel sensing elements, immobilization techniques, detection strategies and miniaturization. Particular emphasis is placed on aspects related to the micro- and nano-conception of these devices.

Dr. Hamdi Ben Halima
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • biosensors
  • environmental sensors
  • biomedical sensors
  • food sensors
  • quality control
  • nanosystems
  • nanomaterials
  • immobilization technologies
  • aptamer-based biosensors
  • enzyme-based biosensors
  • cell-based biosensors
  • DNA-based biosensors
  • immunosensors
  • Lab on a chip (LOC)
  • miniaturization
  • microstructured sensors
  • nanostructured sensors
  • biomarker detection
  • pollutant detection
  • contaminant detection
  • xenobiotic detection

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Published Papers (1 paper)

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Research

16 pages, 4491 KiB  
Article
An Electrochemical Immunosensor for Sensitive Detection of Exosomes Based on Au/MXenes and AuPtPdCu
by Jie Gao, Rong Yang, Xiaorui Zhu, Jiling Shi, Sufei Wang and Aihua Jing
Micromachines 2025, 16(3), 280; https://doi.org/10.3390/mi16030280 - 27 Feb 2025
Viewed by 524
Abstract
Exosomes are important biomarkers for liquid biopsy in early cancer screening which play important roles in many biological processes, including apoptosis, inflammatory response, and tumor metastasis. In this study, an electrochemical aptamer immunosensor based on Au/MXene and AuPtPdCu was constructed for the sensitive [...] Read more.
Exosomes are important biomarkers for liquid biopsy in early cancer screening which play important roles in many biological processes, including apoptosis, inflammatory response, and tumor metastasis. In this study, an electrochemical aptamer immunosensor based on Au/MXene and AuPtPdCu was constructed for the sensitive detection of colorectal cancer-derived exosomes. AuNPs were deposited in situ on the surface of MXenes as a sensing platform due to their large specific area, excellent conductivity, and higher number of active sites for aptamer immobilization. The aptamer CD63 immobilized on Au/MXene can specifically capture target exosomes. Therefore, the AuPtPdCu-Apt nanoprobe further enhanced the sensitivity and accuracy of the immunosensor. A low limit of detection of 19 particles μL−1 was achieved in the linear range of 50 to 5 × 104 particles μL−1 under optimal conditions. The immunosensor developed herein showed satisfactory electrochemical stability and anti-interference ability for the detection of exosomes in real serum samples. Full article
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