Micro- and Nano-Engineered Biomaterials and Devices for Regenerative Medicine and Therapeutics

Dear Colleagues,

Micro- and nano-engineered biomaterials are rapidly transforming the fields of regenerative medicine and therapeutic delivery. Recent advances—including self-healing hydrogels, microneedle-based delivery devices, microfluidic systems, extracellular vesicle-integrated biomaterials, and bioinspired micro/nanostructures—have enabled unprecedented control over cellular behavior, tissue repair, and real-time physiological responses. These technologies often incorporate sensing or stimuli-responsive functions, bridging the gap between biosensors, smart biomaterials, and therapeutic microdevices.

By bringing together multidisciplinary advances—from microfluidic fabrication and microneedle engineering to smart biomaterials and biomimetic architectures—this Special Issue seeks to showcase emerging technologies that push the boundaries of regenerative medicine and next-generation therapeutic strategies.

Topics of interest include, but are not limited to, the following:

• Micro- and nano-engineered hydrogels and soft materials for regenerative therapies;
• Microneedle devices for drug delivery, wound healing, and localized treatment;
• Microfluidic and 3D-bioprinted constructs for tissue repair and disease modeling;
• Smart, responsive, or sensing-enabled biomaterials for real-time monitoring;
• Bioinspired micro/nanostructures for enhanced adhesion, hemostasis, or tissue integration;
• Micro- and nano-devices for controlled drug release or regenerative medicine.

Dr. Bin Kong
Guest Editor

Dr. Yu Song
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.