The Relationship Between Adipose Tissue Insulin Resistance and Metabolic Syndrome
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 15 November 2025 | Viewed by 50
Special Issue Editor
Interests: adipocyte biology; metabolism; physiology; obesity; type two diabetes; insulin signaling; omics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic syndrome represents a significant global health challenge, affecting approximately 25% of the world's adult population and substantially increasing the risk of type 2 diabetes, cardiovascular diseases, and non-alcoholic fatty liver disease. While insulin resistance has long been recognized as a central pathophysiological feature of metabolic syndrome, emerging evidence highlights the critical and unique role of adipose tissue insulin resistance (Adipo-IR) in disease progression and manifestation.
This Special Issue aims to explore the intricate relationship between adipose tissue insulin resistance and metabolic syndrome, focusing on molecular mechanisms, clinical implications, and potential therapeutic targets. We welcome original research articles, comprehensive reviews, and perspective pieces that advance our understanding of how adipose tissue dysfunction contributes to metabolic derangements.
Focus Areas
- Molecular and cellular mechanisms underlying adipose tissue insulin resistance;
- Adipocytokine dysregulation and its systemic metabolic consequences;
- Role of adipose tissue inflammation in metabolic syndrome pathogenesis;
- Inter-organ crosstalk between adipose tissue and other metabolic organs;
- Novel biomarkers for adipose tissue insulin resistance assessment;
- Genetic and epigenetic factors influencing adipose insulin sensitivity;
- Lifestyle, dietary, and pharmacological interventions targeting adipose insulin resistance;
- Sex and age differences in adipose tissue function and metabolic syndrome.
By compiling cutting-edge research on this topic, this Special Issue aims to facilitate a deeper understanding of how adipose-specific insulin resistance contributes to metabolic syndrome development and progression. We seek to identify novel therapeutic strategies and create a platform for interdisciplinary dialogue between basic scientists and clinicians working in this rapidly evolving field. Ultimately, we hope to catalyze research that may translate into improved management and prevention strategies for metabolic syndrome and its associated complications.
Dr. Atefeh Rabiee
Guest Editor
Manuscript Submission Information
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Keywords
- adipose insulin resistance
- metabolic syndrome
- visceral adiposity
- adipocytokines
- insulin signaling
- lipolysis dysregulation
- cardiometabolic risk
- lipotoxicity
- adipose inflammation
- insulin sensitivity
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