Frontiers in the Study of Metabolic Diseases Using Rodent Models

Dear Colleagues,

Metabolomics is an important tool in modern scientific research and clinical diagnostics. Smaller-scale targeted metabolite analyses have been used in both research and diagnostics settings for decades. In recent years, the use of untargeted, large-scale metabolite profiling, fueled by rapid developments in chromatography, mass spectrometry and nuclear magnetic resonance spectroscopy techniques, metabolite databases and data-analysis software, is gaining momentum. Metabolomics alone, or in combination with genomics (and other ‘omics’) data can  in particular be useful for understanding and later on for diagnosis of human metabolic diseases. While caused by single-gene mutations, these diseases usually are characterized by complex metabolic phenotypes, which makes quick diagnosis difficult.

This Special Issue aims to explore the contribution of metabolomics approaches to understanding the interaction between genotype, metabolism, and phenotype specifically in mouse models of human metabolic disease. The topics will include, but are not limited to, the generation and characterization of novel mouse models of human metabolic diseases, new insights in pathogenesis, interaction between disease phenotype and environmental factors, testing of treatment strategies, and preclinical biomarker discovery. Moreover, we invite manuscripts addressing the methodological challenges as well as presenting novel analytical techniques relevant to tackling the topics listed above.

Dr. Jolita Ciapaite
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.