Metabolic Profiles and Biomarkers in Pregnancy

Dear Colleagues,

Metabolomics is one of the most promising "omics" sciences. It is a holistic technique, which tends to consider a series of complex factors, bringing them together in a whole that affects the cell and, ultimately, the individual. Metabolomics can study the metabolic complexity of cells, tissues, as well as of an entire organism. In practical terms, metabolomics, through the analysis of metabolites, allows analyzing the single final product of gene activation/inactivation, which in turn involves an activation/inactivation of the messenger RNA, which can set in motion the powerful enzymatic machine analyzed by the genome/proteome. It is therefore a question of evaluating the final metabolic product. In practice, any small molecule with a mass of less than 1 kD can be detected by metabolomic analysis. Since the metabolic product is influenced by the environment, metabolomic analysis allows an interesting intersection of information and allows analyzing the relationships between genotype and phenotype and intercorrelating this information. In normal and pathological pregnancy, metabolomics can unveil metabolic details and define normal and pathological metabolic trajectories of pregnancy.

In this Special Issue, we would like to focus on metabolomic changes in major obstetric syndromes in pregnancy and on the consequences of metabolic syndrome in pregnancy, and on the consequences of environmental pollution on the different metabolic profiles of pregnancy. This Special Issue will have five different sections:

1) Metabolomics and premature birth;

2) Metabolomics and metabolic syndrome;

3) Metabolomics and preeclampsia;

4) Metabolomics and diabetes;

5) Metabolomics and environmental pollution.

Prof. Dr. Antonio Ragusa
Prof. Dr. Corrado Terranova
Guest Editors

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