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Metabolites
Special Issues
Nutritional Metabolic or Clinical Diseases in Mammals and Poultry
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Nutritional Metabolic or Clinical Diseases in Mammals and Poultry

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 11479

Special Issue Editors

Dr. Xishuai Tong

E-Mail Website
Guest Editor
Joint International Research laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Interests: animal metabolism; animal nurtition; bone; heavy metal; blood; public health
Dr. Shu-cheng Huang

E-Mail Website
Guest Editor
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China
Interests: poultry science; poultry bone diseases; animal nutrition; mycotoxins; microbiome; metabolomics
Dr. Qiwen Wang

E-Mail Website
Guest Editor
College of Life Science, Henan Normal University, Xinxiang 453007, China
Interests: heavy-organic nanomaterials; liver regeneration; cellular metabolism; autophagy
Prof. Dr. Jicang Wang

E-Mail Website
Guest Editor
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China
Interests: metabolic diseases; heavy metal; public health; animal disease prevention
Dr. Lihong Zhang

E-Mail Website
Guest Editor
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China
Interests: ruminant; animal metabolism; animal nutrition; microbiome; metabolomics

Special Issue Information

Dear Colleagues,

Animal metabolic disease is a complicated issue that can arise in a variety of species, including mammals and poultry, as well as model animals (e.g., mice, zebrafish, etc.). Treating animal metabolic disease does not only require more specific knowledge of the anatomical structures of these animals, but it also requires us to understand how to regulate their metabolic routines. Metabolic disease in animals is outstandingly intricate, requiring the use of multiplexing methods and/or techniques for its profiling. In fact, how to clarify certain types is also a problem that still needs to be solved. Importantly, animal health is closely associated with survival conditions, including the generation of nutrition composition in the growth process and the living environment, such as environmental health influenced by heavy metals, mycotoxins, pathogenic microbes, etc. Therefore, how to find nutritional metabolic or clinical diagnostic methods and applications in animals is a challenging issue, which is not restricted to the internal factors of the animal itself but also includes other external influences.

In this Special Issue, “Nutritional Metabolic or Clinical Diseases in Mammals and Poultry”, we will publish original research articles, review articles, and short communications covering the latest advances in veterinary diagnosis in different fields. This issue is not only intended for applications in basic research (animal or cell models) but also aims to report the results of clinical diagnostic studies of basic diagnosis and pathogens. In addition, novel tools, data analysis, and calculated methods are welcome.

Dr. Xishuai Tong
Dr. Shu-cheng Huang
Dr. Qiwen Wang
Prof. Dr. Jicang Wang
Dr. Lihong Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal metabolism
  • animal nutrition
  • poultry science
  • animal nutrition
  • bone
  • heavy metal
  • mycotoxins
  • microbiome
  • metabolomics
  • public health
  • autophagy
  • nanomaterial
  • parasite and metabolic diseases
  • gut microbes and metabolic diseases
  • trace elements
  • probiotics and prebiotics

Published Papers (4 papers)

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Research

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17 pages, 4140 KiB  
Article
Expression Analysis of Molecular Chaperones Hsp70 and Hsp90 on Development and Metabolism of Different Organs and Testis in Cattle (Cattle–yak and Yak)
by Yan Cui, Penggang Liu, Sijiu Yu, Junfeng He, Seth Y. Afedo, Shengnan Zou, Qian Zhang, Jun Liu, Liangli Song, Yuanfang Xu, Ting Wang and Hui Li
Metabolites 2022, 12(11), 1114; https://doi.org/10.3390/metabo12111114 - 15 Nov 2022
Cited by 3 | Viewed by 1413
Abstract
Hsp70 and Hsp90 play an important role in testis development and spermatogenesis regulation, but the exact connection between Hsp70 and Hsp90 and metabolic stress in cattle is unclear. Here, we focused on the male cattle–yak and yak, investigated the expression and localization of [...] Read more.
Hsp70 and Hsp90 play an important role in testis development and spermatogenesis regulation, but the exact connection between Hsp70 and Hsp90 and metabolic stress in cattle is unclear. Here, we focused on the male cattle–yak and yak, investigated the expression and localization of Hsp70 and Hsp90 in their tissues, and explored the influence of these factors on development and metabolism. In our study, a total of 54 cattle (24 cattle–yaks and 30 yaks; aged 1 day to 10 years) were examined. The Hsp90 mRNA of the cattle–yak was first cloned and compared with that of the yak, and variation in the amino acid sequence was found, which led to differences in protein spatial structure. Using real-time quantitative PCR (RT-qPCR) and Western blot (WB) techniques, we investigated whether the expression of Hsp70 and Hsp90 mRNA and protein are different in the cattle–yak and yak. We found a disparity in Hsp70 and Hsp90 mRNA and protein expression in different non-reproductive organs and in testicular tissues at different stages of development, while high expression was observed in the testes of both juveniles and adults. Moreover, it was intriguing to observe that Hsp70 expression was significantly high in the yak, whereas Hsp90 was high in the cattle–yak (p < 0.01). We also examined the location of Hsp70 and Hsp90 in the testis by immunohistochemical (IHC) and immunofluorescence (IF) techniques, and the results showed that Hsp70 and Hsp90 were positive in the epithelial cells, spermatogenic cells, and mesenchymal cells. In summary, our study proved that Hsp70 and Hsp90 expressions were different in different tissues (kidney, heart, cerebellum, liver, lung, spleen, and testis), and Hsp90 expression was high in the testis of the cattle–yak, suggesting that dysplasia of the cattle–yak may correlate with an over-metabolism of Hsp90. Full article
(This article belongs to the Special Issue Nutritional Metabolic or Clinical Diseases in Mammals and Poultry)
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18 pages, 6751 KiB  
Article
Morinda officinalis Polysaccharides Ameliorates Bone Growth by Attenuating Oxidative Stress and Regulating the Gut Microbiota in Thiram-Induced Tibial Dyschondroplasia Chickens
by Chaodong Zhang, Tingting Xu, Luxi Lin, Aftab Shaukat, Xishuai Tong, Ke Yue, Qinqin Cao, Cai Zhang, Fang Liu and Shucheng Huang
Metabolites 2022, 12(10), 958; https://doi.org/10.3390/metabo12100958 - 10 Oct 2022
Cited by 8 | Viewed by 1770
Abstract
Tibial dyschondroplasia (TD) occurs in chickens and other fast-growing birds, affecting their cartilage growth and leading to reduced meat quality in broilers. Morinda officinalis polysaccharide (MOP) is one of the chief active components of Morinda officinalis, which promotes bone formation, inhibiting bone [...] Read more.
Tibial dyschondroplasia (TD) occurs in chickens and other fast-growing birds, affecting their cartilage growth and leading to reduced meat quality in broilers. Morinda officinalis polysaccharide (MOP) is one of the chief active components of Morinda officinalis, which promotes bone formation, inhibiting bone loss and having anti-oxidant and anti-inflammatory properties. A total of 120 AA chickens were randomly divided into the CON group (basal diet), TD group (100 mg/kg thiram + basal diet), and MOP group (100 mg/kg thiram + basal diet + water with 500 mg/kg MOP). The experiment lasted 21 days. The results showed that MOP could alleviates broiler lameness caused by TD, restore the morphological structure of tibial growth plate (TGP), increase tibial weight (p < 0.05), balance the disorder of calcium and phosphorus metabolism, and promote bone formation by increasing the expression of BMP-2, Smad4, and Runx2 genes In addition, MOP supplementation stimulated the secretion of plasma antioxidant enzymes (T-SOD and GSH-Px) by regulating the expression of SOD and GPX-1 genes, thereby enhancing the antioxidant capacity of TD broilers. Interestingly, we observed MOP can also improve gut microbiota by increasing the beneficial bacteria count and decreasing the harmful bacteria count. These findings indicated that MOP can regulate bone formation through the BMP/Smads signaling pathway, attenuating oxidative stress and regulating the gut microbiota of TD broilers, so as to achieve the effect of treating TD. This suggests that MOP might be a potential novel drug in the treatment of TD in chickens. Full article
(This article belongs to the Special Issue Nutritional Metabolic or Clinical Diseases in Mammals and Poultry)
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Review

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17 pages, 2022 KiB  
Review
Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies
by Xiaoyu Ji, Ning Liu, Yuqin Wang, Ke Ding, Shucheng Huang and Cai Zhang
Metabolites 2023, 13(2), 149; https://doi.org/10.3390/metabo13020149 - 18 Jan 2023
Cited by 2 | Viewed by 3904
Abstract
Pregnancy toxemia is a nutritional metabolic disease during late gestation in small ruminants. The condition is characterized by disorders in carbohydrate and fat metabolism. Obese and multiparous ewes are particularly susceptible to pregnancy toxemia, which may lead to maternal death, abortion, or premature [...] Read more.
Pregnancy toxemia is a nutritional metabolic disease during late gestation in small ruminants. The condition is characterized by disorders in carbohydrate and fat metabolism. Obese and multiparous ewes are particularly susceptible to pregnancy toxemia, which may lead to maternal death, abortion, or premature birth. Highly productive multiparous meat ewes are major breeding animals, which has led to an increased incidence of the disease. However, the pathogenesis of pregnancy toxemia remains unclear and adequate disease prevention and treatment strategies are absent. Investigating the pathogenesis of pregnancy toxemia, especially the metabolic pathways of hepatic lipids, is key to an improved understanding of the condition. This review provides a snapshot of the genes that are associated with lipid metabolism in the ovine liver, including genes involved in fatty acid oxidation, acetyl coenzyme metabolism, and triglyceride synthesis; describes the interrelationships between these genes; and summarizes the diagnosis, prevention, and treatment of pregnancy toxemia. Full article
(This article belongs to the Special Issue Nutritional Metabolic or Clinical Diseases in Mammals and Poultry)
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18 pages, 1618 KiB  
Review
Effects of Probiotics and Gut Microbiota on Bone Metabolism in Chickens: A Review
by Pan Chen, Tingting Xu, Chaodong Zhang, Xishuai Tong, Aftab Shaukat, Yanfeng He, Kaili Liu and Shucheng Huang
Metabolites 2022, 12(10), 1000; https://doi.org/10.3390/metabo12101000 - 20 Oct 2022
Cited by 10 | Viewed by 2957
Abstract
Broiler leg diseases are a common abnormal bone metabolism issue that leads to poor leg health in growing poultry. Bone metabolism is a complicated regulatory process controlled by genetic, nutritional, feeding management, environmental, or other influencing factors. The gut microbiota constitutes the largest [...] Read more.
Broiler leg diseases are a common abnormal bone metabolism issue that leads to poor leg health in growing poultry. Bone metabolism is a complicated regulatory process controlled by genetic, nutritional, feeding management, environmental, or other influencing factors. The gut microbiota constitutes the largest micro-ecosystem in animals and is closely related to many metabolic disorders, including bone disease, by affecting the absorption of nutrients and the barrier function of the gastrointestinal tract and regulating the immune system and even the brain–gut–bone axis. Recently, probiotic-based dietary supplementation has emerged as an emerging strategy to improve bone health in chickens by regulating bone metabolism based on the gut–bone axis. This review aims to summarize the regulatory mechanisms of probiotics in the gut microbiota on bone metabolism and to provide new insights for the prevention and treatment of bone diseases in broiler chickens. Full article
(This article belongs to the Special Issue Nutritional Metabolic or Clinical Diseases in Mammals and Poultry)
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