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Biomechanics and Mechanobiology at the Cell-Biomaterial Interface
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Biomechanics and Mechanobiology at the Cell-Biomaterial Interface

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (1 May 2021) | Viewed by 5341

Special Issue Editors

Prof. Dr. Alberto Rainer

E-Mail Website
Guest Editor
Faculty of Engineering, Università Campus Bio-Medico di Roma, 00128 Rome, Italy
Interests: biofabrication; microfluidics; cell mechanobiology; in vitro models
Special Issues, Collections and Topics in MDPI journals
Dr. Francesco Basoli

E-Mail Website
Guest Editor
Department of Engineering, Università Campus Bio-Medico di Roma, 00128 Rome, Italy
Interests: tissue engineering; materials science; microscopy; nanotechnologies; scaffolds

Special Issue Information

Dear Colleagues,

Living tissues are characterized by a dynamic equilibrium between cells and the extracellular matrix (ECM), with cells actively synthesizing ECM, which in turn provides cells with distinctive biochemical and mechanical cues.

Unveiling the complexity of cell–ECM interplay will foster the design of next-generation biomaterials able to guide cell differentiation and tissue homeostasis, driving new advances in tissue engineering.

This Special Issue will provide readers with an overview on cell–biomaterial interaction, with a focus on biomechanical and mechanobiological aspects. Contributions will be selected at the convergence of materials science, biology, and bioengineering, based on their ability to envisage the future of biomaterials science.

Prof. Alberto Rainer
Dr. Francesco Basoli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomaterials
  • biomechanics
  • mechanobiology
  • tissue engineering
  • cell–ECM interplay

Published Papers (1 paper)

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Review

18 pages, 1443 KiB  
Review
Cellular Geometry Sensing at Different Length Scales and its Implications for Scaffold Design
by Maike Werner, Nicholas A. Kurniawan and Carlijn V. C. Bouten
Materials 2020, 13(4), 963; https://doi.org/10.3390/ma13040963 - 21 Feb 2020
Cited by 43 | Viewed by 4754
Abstract
Geometrical cues provided by the intrinsic architecture of tissues and implanted biomaterials have a high relevance in controlling cellular behavior. Knowledge of how cells sense and subsequently respond to complex geometrical cues of various sizes and origins is needed to understand the role [...] Read more.
Geometrical cues provided by the intrinsic architecture of tissues and implanted biomaterials have a high relevance in controlling cellular behavior. Knowledge of how cells sense and subsequently respond to complex geometrical cues of various sizes and origins is needed to understand the role of the architecture of the extracellular environment as a cell-instructive parameter. This is of particular interest in the field of tissue engineering, where the success of scaffold-guided tissue regeneration largely depends on the formation of new tissue in a native-like organization in order to ensure proper tissue function. A well-considered internal scaffold design (i.e., the inner architecture of the porous structure) can largely contribute to the desired cell and tissue organization. Advances in scaffold production techniques for tissue engineering purposes in the last years have provided the possibility to accurately create scaffolds with defined macroscale external and microscale internal architectures. Using the knowledge of how cells sense geometrical cues of different size ranges can drive the rational design of scaffolds that control cellular and tissue architecture. This concise review addresses the recently gained knowledge of the sensory mechanisms of cells towards geometrical cues of different sizes (from the nanometer to millimeter scale) and points out how this insight can contribute to informed architectural scaffold designs. Full article
(This article belongs to the Special Issue Biomechanics and Mechanobiology at the Cell-Biomaterial Interface)
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