Special Issue "Biomaterials Used in Clinical Practice and Their Tribological Behaviours Assessed In Vitro, In Silico, and In Vivo"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Dr. Saverio Affatato
Guest Editor
Laboratorio di Tecnologia Medica, IRCCS – Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy
Interests: biotribology; ceramic; metal; composite; biomaterials; hip; knee; simulator; in silico; prosthesis
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Special Issue Information

Dear Colleagues,

It is a great pleasure to announce this Special Issue on “Biomaterials used in Clinical Practice and Their Tribological Behavior Assessed in Vitro, in Silico, and in Vivo”.

Joint replacement surgeries (hip, knee, ankle, etc.) are a successful and consolidated branch of orthopedics. The progressive achievement in alleviating pain and disability helps patients to return to an active life. Research in new biomaterials plays an important role, and as a consequence, in vitro and in silico tests for such materials are of great importance. The knowledge of the laboratory wear rate is an important aspect in the preclinical validation of prostheses. Research and development of wear-resistant materials continues to be a high priority in order to evaluate the performance of new materials intended to reduce wear, which is essential to ascertaining their efficacy and preventing the possibility of unexpected failure. Obviously, wear tests have a long duration, and they are very expensive. In recent years, “prediction of wear” in hip and knee replacements has been a subject of intense study. In silico investigation, where algorithms could be developed to model a biomedical process, is a logical extension of controlled in vitro experimentation. It is the natural result of the explosive increase in computing power available to scientists; thus, numerical models could be used to predict results of a wear test with less time and cost. Obviously, the in silico analysis integrates but does not replace the experimental tools. In silico methods based on musculoskeletal modeling simulations are powerful tools that allow biomechanical investigations and predictions of muscle forces not accessible with experiments; this allows us to develop subject-specific models able to simultaneously predict muscle, ligament, and knee joint contact forces, which may be used to test orthopedic implants with patient-specific load configuration. The in silico approach constitutes a promising methodology in arthroplasty, allowing the prediction of tribological phenomena in preclinical wear tests.

This international peer-reviewed open access journal is indexed by the Science Citation Index Expanded (Web of Science) ISSN: 1996-1944, Impact Factor: 2.972.

I hope to receive many interesting contributions.

Best Regards,

Dr. Saverio Affatato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Hip prostheses
  • Knee prostheses
  • Ankle prostheses
  • Orthopedic
  • Biomaterials
  • Composites
  • Alloys
  • Wear
  • Biotribology
  • SEM analyses
  • Micro-CT analyses
  • FEM
  • Ceramic
  • Metal
  • Polyethylene
  • Lubrication
  • Temporary spacer
  • Raman spectroscopy
  • In silico simulation
  • Multibody model
  • Corrosion

Published Papers

This special issue is now open for submission.
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