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Bioactive Glasses

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A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (31 March 2016) | Viewed by 50289

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Prof. Dr. Gigliola Lusvardi

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Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via G.Campi 103, 41125 Modena, Italy
Interests: biomaterials; bioceramics; bioglasses; metallic nanoparticles; drug delivery systems; synthesis (traditional, sol-gel and sono-gel); functional biomaterials; surface functionalization; biosensors; characterization (x-ray diffraction, electron microscopy)
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Dear Colleagues,

Bioactive glasses are a group of surface reactive glass-ceramic biomaterials; bioactive glasses bond to tissue and are biocompatible. They have a wide range of applications due to their versatile properties, which can be properly designed depending on their compositions. A significant improvement in the prevision of glass bioactivity derives from the opportunity to establish relationships between structure and properties by making a combined use of theoretical and experimental techniques. Consequently, bioactive glass science and technology continues to be at the forefront of providing innovative approaches to medicine.

The focus of the “Bioactive Glasses” Special Issue is to provide and comprehend important topics: synthesis, design, development, and applications of bioglasses. Some interesting topics (among others, and certainly not limited to) are: bioderived bioglasses with functionalized nanostructures, encapsulation and adsorption of biomolecules in the surface of bioglasses and interactions with the host matrix, and molecular dynamics simulation applied at atomic level regarding bulk and surface structure of the glasses.

With immense pleasure, we invite you to submit a manuscript for this Special Issue.

Full papers, communications, and reviews are welcome.

Prof Gigliola Lusvardi
Guest Editor

Manuscript Submission Information

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Keywords

bioactive glasses
materials science
bioactivity
metal nanoparticles
glass structure
surface functionalization
drug delivery systems

Published Papers (7 papers)

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Research

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11196 KiB

Open AccessFeature PaperArticle

Bioactive and Antibacterial Glass Powders Doped with Copper by Ion-Exchange in Aqueous Solutions

by Marta Miola and Enrica Verné

Materials 2016, 9(6), 405; https://doi.org/10.3390/ma9060405 - 24 May 2016

Cited by 32 | Viewed by 6133

Abstract

In this work, two bioactive glass powders (SBA2 and SBA3) were doped with Cu by means of the ion-exchange technique in aqueous solution. SBA2 glass was subjected to the ion-exchange process by using different Cu salts (copper(II) nitrate, chloride, acetate, and sulphate) and concentrations. Structural (X-ray diffraction-XRD), morphological (Scanning Electron Microscopy-SEM), and compositional (Energy Dispersion Spectrometry-EDS) analyses evidenced the formation of crystalline phases for glasses ion-exchanged in copper(II) nitrate and chloride solutions; while the ion-exchange in copper(II) acetate solutions lead to the incorporation of higher Cu amount than the ion-exchange in copper(II) sulphate solutions. For this reason, the antibacterial test (inhibition halo towards S. aureus) was performed on SBA2 powders ion-exchanged in copper(II) acetate solutions and evidenced a limited antibacterial effect. A second glass composition (SBA3) was developed to allow a greater incorporation of Cu in the glass surface; SBA3 powders were ion-exchanged in copper(II) acetate solutions (0.01 M and 0.05 M). Cu-doped SBA3 powders showed an amorphous structure; morphological analysis evidenced a rougher surface for Cu-doped powders in comparison to the undoped glass. EDS and X-ray photoelectron spectroscopy (XPS) confirmed the Cu introduction as Cu(II) ions. Bioactivity test in simulated body fluid (SBF) showed that Cu introduction did not alter the bioactive behaviour of the glass. Finally, inhibition halo test towards S. aureus evidenced a good antimicrobial effect for glass powders ion-exchanged in copper(II) acetate solutions 0.05 M. Full article

(This article belongs to the Special Issue Bioactive Glasses)

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2855 KiB

Open AccessArticle

SiO₂-CaO-P₂O₅ Bioactive Glasses: A Promising Curcuminoids Delivery System

by Valentina Nicolini, Monica Caselli, Erika Ferrari, Ledi Menabue, Gigliola Lusvardi, Monica Saladini and Gianluca Malavasi

Materials 2016, 9(4), 290; https://doi.org/10.3390/ma9040290 - 15 Apr 2016

Cited by 12 | Viewed by 5443

Abstract

In this paper, we report the study of the loading and the release of curcuminoids by bioactive glasses (BG) and mesoporous bioactive glasses (MBG). Through a detailed spectroscopic study, it was possible to determine the amount and the type of molecules released in water and in simulated body fluid (SBF). In particular, curcumin and K2T21 show a good ability to be released in di-keto and keto-enolic form, depending from the pH. However, after 24 h, the amount of pristine curcumin release is very low with a consequent increment of degradation products derived by curcuminoids. The presence of –OH groups on curcuminoids is a fundamental pre-requisite in order to obtain a high loading and release in polar solution such as water and SBF. The substrate on which we loaded the drugs does not seem to affect significantly the loading and the release of the drugs. The environment, instead, affects the release: for all the drugs, the release in SBF, buffered at pH of 7.4, is slightly worse than the release in water (basic pH values). Full article

(This article belongs to the Special Issue Bioactive Glasses)

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4765 KiB

Open AccessFeature PaperArticle

Bioactive Glasses with Low Ca/P Ratio and Enhanced Bioactivity

by Marco Araújo, Marta Miola, Giovanni Baldi, Javier Perez and Enrica Verné

Materials 2016, 9(4), 226; https://doi.org/10.3390/ma9040226 - 24 Mar 2016

Cited by 27 | Viewed by 5235

Abstract

Three new silica-based glass formulations with low molar Ca/P ratio (2–3) have been synthesized. The thermal properties, the crystalline phases induced by thermal treatments and the sintering ability of each glass formulation have been investigated by simultaneous differential scanning calorimetry-thermogravimetric analysis (DSC-TG), X-ray diffraction (XRD) and hot stage microscopy (HSM). The glasses exhibited a good sintering behavior, with two samples achieving shrinkage of 85%–95% prior to crystallization. The bioactivity of the glasses in simulated body fluid (SBF) has been investigated by performing XRD and Fourier transform infrared spectroscopy (FTIR) on the samples prior and after immersion. The glasses with lower MgO contents were able to form a fully crystallized apatite layer after three days of immersion in simulated body fluid (SBF), while for the glass exhibiting a higher MgO content in its composition, the crystallization of the Ca–P layer was achieved after seven days. The conjugation of these properties opens new insights on the synthesis of highly bioactive and mechanically strong prosthetic materials. Full article

(This article belongs to the Special Issue Bioactive Glasses)

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1503 KiB

Open AccessFeature PaperCommunication

Synthesis of Monodispersed Ag-Doped Bioactive Glass Nanoparticles via Surface Modification

by Dominika Kozon, Kai Zheng, Elena Boccardi, Yufang Liu, Liliana Liverani and Aldo R. Boccaccini

Materials 2016, 9(4), 225; https://doi.org/10.3390/ma9040225 - 24 Mar 2016

Cited by 54 | Viewed by 6580

Abstract

Monodispersed spherical Ag-doped bioactive glass nanoparticles (Ag-BGNs) were synthesized by a modified Stöber method combined with surface modification. The surface modification was carried out at 25, 60, and 80 °C, respectively, to investigate the influence of processing temperature on particle properties. Energy-dispersive X-ray spectroscopy (EDS) results indicated that higher temperatures facilitate the incorporation of Ag. Hydroxyapatite (HA) formation on Ag-BGNs was detected upon immersion of the particles in simulated body fluid for 7 days, which indicated that Ag-BGNs maintained high bioactivity after surface modification. The conducted antibacterial assay confirmed that Ag-BGNs had an antibacterial effect on E. coli. The above results thereby suggest that surface modification is an effective way to incorporate Ag into BGNs and that the modified BGNs can remain monodispersed as well as exhibit bioactivity and antibacterial capability for biomedical applications. Full article

(This article belongs to the Special Issue Bioactive Glasses)

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1971 KiB

Open AccessFeature PaperArticle

Alendronate Functionalized Mesoporous Bioactive Glass Nanospheres

by Elisa Boanini, Silvia Panseri, Fabiola Arroyo, Monica Montesi, Katia Rubini, Anna Tampieri, Cristian Covarrubias and Adriana Bigi

Materials 2016, 9(3), 135; https://doi.org/10.3390/ma9030135 - 26 Feb 2016

Cited by 18 | Viewed by 5767

Abstract

In this work we synthesized mesoporous bioactive glass nanospheres (nMBG) with the aim to utilize them as substrates for loading one of the most potent amino-bisphosphonates, alendronate (AL). The results of the chemical and structural characterization show that the nMBG display a relatively high surface area (528 m²/g) and a mean pore volume of 0.63 cm³/g, both of which decrease on increasing alendronate content. It is possible to modulate the amount of AL loaded into the nanospheres up to a maximum value of about 17 wt %. In vitro tests were performed using a human osteosarcoma cell line (MG63) and a murine monocyte/macrophage cell line as osteoclast model (RAW 264.7). The results indicate that even the lower concentration of alendronate provokes decreased tumor cell viability, and that osteoclast activity exhibits an alendronate dose-dependent inhibition. The data suggest that nMBG can act as a suitable support for the local delivery of alendronate, and that the antiresorptive and antitumor properties of the functionalized mesoporous nanospheres can be modulated by varying the amount of alendronate loading. Full article

(This article belongs to the Special Issue Bioactive Glasses)

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1664 KiB

Open AccessArticle

The Correlation of Surfactant Concentrations on the Properties of Mesoporous Bioactive Glass

by Shao-Ju Shih, Yu-Chien Lin, Leon Valentino Posma Panjaitan and Dyka Rahayu Meyla Sari

Materials 2016, 9(1), 58; https://doi.org/10.3390/ma9010058 - 19 Jan 2016

Cited by 22 | Viewed by 5131

Abstract

Bioactive glass (BG), a potential biomaterial, has received increasing attention since the discovery of its superior bioactivity. One of the main research objectives is to improve the bioactive property of BGs; therefore, surfactant-derived mesoporous bioactive glasses (MBGs) were developed to provide a high specific surface area for achieving higher bioactivity. In this study, various concentrations of typical triblock F127 surfactant were used to manipulate the morphology, specific surface area, and bioactivity of MBG particles. Two typical morphologies of smooth (Type I) and wrinkled (Type II) spheres were observed, and the population of Type II particles increased with an increase in the surfactant concentration. A direct correlation between specific surface area and bioactivity was observed by comparing the data obtained using the nitrogen adsorption-desorption method and in vitro bioactive tests. Furthermore, the optimal surfactant concentration corresponding to the highest bioactivity revealed that the surfactant aggregated to form Type II particles when the surface concentration was higher than the critical micelle concentration, and the high population of Type II particles may reduce the specific surface area because of the loss of bioactivity. Moreover, the formation mechanism of SP-derived MBG particles is discussed. Full article

(This article belongs to the Special Issue Bioactive Glasses)

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Review

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1760 KiB

Open AccessFeature PaperReview

Bioactive Glass Nanoparticles: From Synthesis to Materials Design for Biomedical Applications

by Charlotte Vichery and Jean-Marie Nedelec

Materials 2016, 9(4), 288; https://doi.org/10.3390/ma9040288 - 14 Apr 2016

Cited by 216 | Viewed by 15191

Abstract

Thanks to their high biocompatibility and bioactivity, bioactive glasses are very promising materials for soft and hard tissue repair and engineering. Because bioactivity and specific surface area intrinsically linked, the last decade has seen a focus on the development of highly porous and/or nano-sized materials. This review emphasizes the synthesis of bioactive glass nanoparticles and materials design strategies. The first part comprehensively covers mainly soft chemistry processes, which aim to obtain dispersible and monodispersed nanoparticles. The second part discusses the use of bioactive glass nanoparticles for medical applications, highlighting the design of materials. Mesoporous nanoparticles for drug delivery, injectable systems and scaffolds consisting of bioactive glass nanoparticles dispersed in a polymer, implant coatings and particle dispersions will be presented. Full article

(This article belongs to the Special Issue Bioactive Glasses)

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