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Biomaterials for Bone Tissue Engineering (Second Volume)
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Biomaterials for Bone Tissue Engineering (Second Volume)

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 10 September 2024 | Viewed by 4551

Special Issue Editors

Dr. Lorenzo Fassina

E-Mail Website
Guest Editor
Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Via Ferrata 5, 27100 Pavia, Italy
Interests: tissue engineering via biomaterials and physical stimuli
Special Issues, Collections and Topics in MDPI journals
Dr. Nora Bloise

E-Mail Website
Guest Editor
Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Viale Taramelli 3/b, 27100 Pavia, Italy
Interests: bone regeneration; biomaterials; mesenchymal stem cell differentiation, cell–biomaterial interaction; bone regeneration; cell culture; molecular biology; cell biology; tissue engineering; biocompatibility; scaffolds; nanomaterials; cellular mechanisms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last few decades, a variety of tissue engineering strategies have been developed to improve the regenerative properties of bone biomaterials (e.g., osteoinduction and osteoconduction). This Special Issue on “Biomaterials for Bone Tissue Engineering” will provide an overview of recent advances and cutting-edge approaches in the field of bone biomaterials and bone tissue engineering, including new molecular insights on the various aspects of the interaction of bone substitutes with cells and tissues. Contributions reporting innovative materials, osteoinduction and osteoconduction approaches, and examples of combination with biochemical and/or physical stimuli and/or different cell types (e.g., stem cells, macrophages, endothelial cells) tested for their application in bone tissue regeneration and engineering are welcome.

Thus, we invite the submission of original full papers, communications, and comprehensive reviews describing the latest progress.

Best Regards,

Dr. Lorenzo Fassina
Dr. Nora Bloise
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone regeneration
  • bone tissue engineering in vitro and in vivo
  • bone substitutes
  • bone marrow stem cells
  • adipose derived stem cells
  • growth factors
  • cell/tissue–biomaterials interaction
  • physical stimuli (ultrasound, laser, electric or electromagnetic field, shear stress, etc.)
  • bioreactors
  • molecular mechanisms

Related Special Issue

Published Papers (3 papers)

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Research

19 pages, 8112 KiB  
Article
Combined Effects of HA Concentration and Unit Cell Geometry on the Biomechanical Behavior of PCL/HA Scaffold for Tissue Engineering Applications Produced by LPBF
by Maria Laura Gatto, Michele Furlani, Alessandra Giuliani, Marcello Cabibbo, Nora Bloise, Lorenzo Fassina, Marlena Petruczuk, Livia Visai and Paolo Mengucci
Materials 2023, 16(14), 4950; https://doi.org/10.3390/ma16144950 - 11 Jul 2023
Cited by 1 | Viewed by 1092
Abstract
This experimental study aims at filling the gap in the literature concerning the combined effects of hydroxyapatite (HA) concentration and elementary unit cell geometry on the biomechanical performances of additively manufactured polycaprolactone/hydroxyapatite (PCL/HA) scaffolds for tissue engineering applications. Scaffolds produced by laser powder [...] Read more.
This experimental study aims at filling the gap in the literature concerning the combined effects of hydroxyapatite (HA) concentration and elementary unit cell geometry on the biomechanical performances of additively manufactured polycaprolactone/hydroxyapatite (PCL/HA) scaffolds for tissue engineering applications. Scaffolds produced by laser powder bed fusion (LPBF) with diamond (DO) and rhombic dodecahedron (RD) elementary unit cells and HA concentrations of 5, 30 and 50 wt.% were subjected to structural, mechanical and biological characterization to investigate the biomechanical and degradative behavior from the perspective of bone tissue regeneration. Haralick’s features describing surface pattern, correlation between micro- and macro-structural properties and human mesenchymal stem cell (hMSC) viability and proliferation have been considered. Experimental results showed that HA has negative influence on scaffold compaction under compression, while on the contrary it has a positive effect on hMSC adhesion. The unit cell geometry influences the mechanical response in the plastic regime and also has an effect on the cell proliferation. Finally, both HA concentration and elementary unit cell geometry affect the scaffold elastic deformation behavior as well as the amount of micro-porosity which, in turn, influences the scaffold degradation rate. Full article
(This article belongs to the Special Issue Biomaterials for Bone Tissue Engineering (Second Volume))
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16 pages, 2948 KiB  
Article
Human Ovarian Follicular Fluid Mesenchymal Stem Cells Express Osteogenic Markers When Cultured on Bioglass 58S-Coated Titanium Scaffolds
by Federica Riva, Nora Bloise, Claudia Omes, Gabriele Ceccarelli, Lorenzo Fassina, Rossella Elena Nappi and Livia Visai
Materials 2023, 16(10), 3676; https://doi.org/10.3390/ma16103676 - 11 May 2023
Viewed by 1389
Abstract
Recent studies have reported that stem cells (human follicular fluid mesenchymal stem cells or hFF-MSCs) are present in ovarian follicular fluid (hFF) and that they have a proliferative and differentiative potential which is similar to that of MSCs derived from other adult tissue. [...] Read more.
Recent studies have reported that stem cells (human follicular fluid mesenchymal stem cells or hFF-MSCs) are present in ovarian follicular fluid (hFF) and that they have a proliferative and differentiative potential which is similar to that of MSCs derived from other adult tissue. These mesenchymal stem cells, isolated from human follicular fluid waste matter discarded after retrieval of oocytes during the IVF process, constitute another, as yet unutilized, source of stem cell materials. There has been little work on the compatibility of these hFF-MSCs with scaffolds useful for bone tissue engineering applications and the aim of this study was to evaluate the osteogenic capacity of hFF-MSCs seeded on bioglass 58S-coated titanium and to provide an assessment of their suitability for bone tissue engineering purposes. Following a chemical and morphological characterization with scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), cell viability, morphology and expression of specific osteogenic markers were examined after 7 and 21 days of culture. The hFF-MSCs seeded on bioglass and cultured with osteogenic factors, when compared with those seeded on tissue culture plate or on uncoated titanium, exhibited enhanced cell viability and osteogenic differentiation, as reflected by increased calcium deposition and increased ALP activity with expression and production of bone-related proteins. Taken together, these results demonstrate that MSCs from human follicular fluid waste materials can be easily cultured in titanium scaffolds coated with bioglass, having osteoinductive properties. This process has significant potential for regenerative medicine applications and indicates that hFF-MSCs may be a valid alternative to hBM-MSC cells in experimental models in bone tissue engineering. Full article
(This article belongs to the Special Issue Biomaterials for Bone Tissue Engineering (Second Volume))
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Graphical abstract

18 pages, 5787 KiB  
Article
Influence of Trabecular Geometry on Scaffold Mechanical Behavior and MG-63 Cell Viability
by Maria Laura Gatto, Giorgia Cerqueni, Michele Furlani, Nicole Riberti, Emanuele Tognoli, Lucia Denti, Francesco Leonardi, Alessandra Giuliani, Monica Mattioli-Belmonte and Paolo Mengucci
Materials 2023, 16(6), 2342; https://doi.org/10.3390/ma16062342 - 15 Mar 2023
Viewed by 1600
Abstract
In a scaffold-based approach for bone tissue regeneration, the control over morphometry allows for balancing scaffold biomechanical performances. In this experimental work, trabecular geometry was obtained by a generative design process, and scaffolds were manufactured by vat photopolymerization with 60% (P60), 70% (P70) [...] Read more.
In a scaffold-based approach for bone tissue regeneration, the control over morphometry allows for balancing scaffold biomechanical performances. In this experimental work, trabecular geometry was obtained by a generative design process, and scaffolds were manufactured by vat photopolymerization with 60% (P60), 70% (P70) and 80% (P80) total porosity. The mechanical and biological performances of the produced scaffolds were investigated, and the results were correlated with morphometric parameters, aiming to investigate the influence of trabecular geometry on the elastic modulus, the ultimate compressive strength of scaffolds and MG-63 human osteosarcoma cell viability. The results showed that P60 trabecular geometry allows for matching the mechanical requirements of human mandibular trabecular bone. From the statistical analysis, a general trend can be inferred, suggesting strut thickness, the degree of anisotropy, connectivity density and specific surface as the main morphometric parameters influencing the biomechanical behavior of trabecular scaffolds, in the perspective of tissue engineering applications. Full article
(This article belongs to the Special Issue Biomaterials for Bone Tissue Engineering (Second Volume))
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