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Smart Biomaterials in Regenerative Engineering

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 1083

Special Issue Editors


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Guest Editor
Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Via Ferrata 5, 27100 Pavia, Italy
Interests: tissue engineering; biomaterials
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Biochemistry Unit, Department of Molecular Medicine, University of Pavia, Viale Taramelli 3/b, 27100 Pavia, Italy
Interests: bone regeneration; biomaterials; mesenchymal stem cell differentiation, cell–biomaterial interaction; cell culture; molecular biology; cell biology; tissue engineering; biocompatibility; scaffolds; nanomaterials; cellular mechanisms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last decades, a variety of tissue engineering strategies have been developed to improve the regenerative properties of biomaterials. This Special Issue on “Smart Biomaterials in Regenerative Engineering” will provide an overview of recent advances and cutting-edge approaches in the field of smart biomaterials, which are able to respond to specific stimuli, enabling them to interact with biological systems in a controlled manner. In particular, smart biomaterials can be generally classified into two categories: those that respond to physical stimuli (e.g., temperature, pressure, light, magnetism or electromagnetism) and those that respond to chemical/biochemical stimuli (e.g., pH, ions’ concentration, or set of enzymes). For example, thermoresponsive hydrogels can react to changes in temperature, causing them to swell or contract, whereas light-responsive materials are stimulated by light triggering the release of drugs or growth factors, or enzyme-responsive scaffolds release drugs in diseased tissues. In addition, smart biomaterials and scaffolds have also tuneable properties such as stiffness, porosity, biodegradability, biosensing of biomolecules, surface chemistry and surface physics. Original contributions are welcome reporting innovative smart biomaterials and examples with chemical, biochemical, physical stimuli and different cell types. Thus, we invite the submission of full papers and reviews describing the latest progress.

Dr. Lorenzo Fassina
Dr. Nora Bloise
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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Keywords

  • tissue regeneration
  • smart biomaterials
  • chemical
  • biochemical
  • physical stimuli
  • cells
  • drugs
  • growth factors
  • cell/tissue–biomaterials interaction

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Published Papers (1 paper)

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Research

16 pages, 3760 KB  
Article
Low-Temperature Plasma Activation of Biomaterials and Its Stability over Time and Post-Sterilisation Effects
by Piotr Trębacz, Mateusz Pawlik, Aleksandra Kurkowska, Karolina Wilk, Agata Piątek and Michał Czopowicz
Materials 2026, 19(3), 643; https://doi.org/10.3390/ma19030643 - 6 Feb 2026
Cited by 1 | Viewed by 694
Abstract
Low-temperature plasma (LTP) activation is increasingly used as a surface modification technique to enhance the wettability and biological performance of metallic implants. However, the stability of plasma-induced surface changes and their interaction with standard sterilisation procedures remain insufficiently understood. This study aimed to [...] Read more.
Low-temperature plasma (LTP) activation is increasingly used as a surface modification technique to enhance the wettability and biological performance of metallic implants. However, the stability of plasma-induced surface changes and their interaction with standard sterilisation procedures remain insufficiently understood. This study aimed to evaluate the effects of LTP activation, steam sterilisation, and their combination with the wettability of metallic implant materials, as well as the temporal stability of these effects. Samples manufactured from Ti6Al4V sheet, additively manufactured Ti6Al4V, and additively manufactured cobalt–chromium alloy were subjected to low-temperature plasma activation, steam sterilisation, or both procedures. Surface wettability was assessed by measuring the contact angle of canine blood droplets immediately after treatment and over a five-day observation period. Low-temperature plasma activation resulted in a substantial reduction in the contact angle for all tested materials, indicating a pronounced increase in surface wettability. However, this effect gradually diminished over time. Steam sterilisation alone moderately improved wettability and showed relatively stable effects. When steam sterilisation was applied after plasma activation, the plasma-induced enhancement was significantly attenuated and rapidly lost during storage. These findings demonstrate that while LTP activation effectively improves surface wettability, its benefits are highly time-dependent and strongly influenced by subsequent sterilisation. Plasma activation should therefore be performed immediately before implantation or combined with sterilisation and storage strategies that preserve surface modifications. Full article
(This article belongs to the Special Issue Smart Biomaterials in Regenerative Engineering)
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