Special Issue "Magnetic Techniques for Molecular Diagnostics and Analysis of Biomolecules"

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: 15 October 2020.

Special Issue Editor

Dr. Joerg Schotter
Website
Guest Editor
Austrian Institute of Technology GmbH, Molecular Diagnostics, Giefinggasse 4, 1210 Vienna, Austria
Interests: Magnetic biosensors, magnetic lab-on-a-chip systems, Magnetic nanoparticle based biosensors, Magnetoresistive sensors and devices

Special Issue Information

Dear Colleagues,

Driven by rising demands for fast and specific results in non-standard environments, in-vitro diagnostics is moving more and more away from centralized laboratories towards point of need applications. At the same time, in biomedical research there is a growing demand for techniques that allow us to study the biophysical properties of single molecules, viruses or cells, including, for example, the determination of mechanical properties (e.g. elasticity or torsion modules) or the investigation of binding strengths.

Magnetic techniques offer exciting possibilities to address these challenges. They rely on the manipulation and detection of biofunctionalized magnetic particles, which—depending on the application—are employed either as labels or probes. The most striking advantage in this regard is the ability to exert forces or torques onto magnetic particles by externally applied magnetic fields. This enables us, for example, to magnetically separate specific biomolecules from a bulk solution (‘magnetic washing’), to draw specific biomolecules towards certain regions (e.g. embedded sensors) in a fluid environment, to agitate magnetic particles and look at their dynamic response for biomolecular detection directly in the bulk sample solution, or to investigate biophysical properties by applying controlled forces or torques via bound magnetic probes. Furthermore, due to the fact that there is no significant magnetic background signal present in biomedical applications, magnetic labels can be detected in very low concentrations, thereby enabling highly competitive detection limits in molecular diagnostics.  

To illustrate the numerous advantages offered by applying magnetic techniques to both the detection and biophysical investigation of biomolecules, viruses or cells, we kindly invite you to submit your manuscript(s) to this Special Issue. Full papers, communications, and reviews are all welcome.

Dr. Jorg Schotter
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Magnetic particle
  • Magnetic force/torque
  • Homogeneous/heterogeneous magnetic biosensor
  • Magnetic transducer
  • Point of need/Point of care
  • Molecular diagnostics/in-vitro diagnostics
  • Single molecule/virus/cell investigation

Published Papers (1 paper)

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Review

Open AccessReview
Magnetic Particles for Advanced Molecular Diagnosis
Materials 2019, 12(13), 2158; https://doi.org/10.3390/ma12132158 - 05 Jul 2019
Abstract
Molecular diagnosis is the field that aims to develop nucleic-acid-based analytical methods for biological markers and gene expression assessments by combining laboratory medicine and molecular genetics. As it gradually becomes a clinical reality, molecular diagnosis could benefit from improvements resulting from thorough studies [...] Read more.
Molecular diagnosis is the field that aims to develop nucleic-acid-based analytical methods for biological markers and gene expression assessments by combining laboratory medicine and molecular genetics. As it gradually becomes a clinical reality, molecular diagnosis could benefit from improvements resulting from thorough studies that could enhance the accuracy of these methods. The application of magnetic particles in molecular diagnosis tools has led to tremendous breakthroughs in terms of specificity, sensitivity, and discrimination in bioassays. Therefore, the aim of this review is to highlight the principles involved in the implementation of magnetic particles for sample preparation and targeted analyte isolation, purification, and extraction. Furthermore, the most recent advancements in the area of cancer and infectious disease diagnosis are presented, with an emphasis on screening and early stage detection. Full article
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