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Biomaterials for Regenerative Medicine: Synthesis, Characterization and Application
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Biomaterials for Regenerative Medicine: Synthesis, Characterization and Application

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1022

Special Issue Editors

Dr. Katarzyna Klimek

E-Mail Website
Guest Editor
Chair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1 Street, 20-059 Lublin, Poland
Interests: cell culture; cell–biomaterial interactions; biocompatibility; hydrogels; polymers; tissue engineering; regenerative medicine; scaffolds
Special Issues, Collections and Topics in MDPI journals
Dr. Julia Higuchi

E-Mail Website
Guest Editor Assistant
Laboratory of Nanostuctures, Institute of High Pressure Physics, Polish Academy of Sciences, Prymasa Tysiaclecia Avenue 98, 01-142 Warsaw, Poland
Interests: nanoparticles; electrospinning; 3D bioprinting; biomaterial characterization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to submit papers on the synthesis and characterization of biomaterials for regenerative medicine (RM). RM and accompanying tissue engineering (TE) are rapidly developing fields that focus, among other matters, on searching for new biomaterials’ compositions that fill or restore the function of the damaged/lost tissues. This Special Issue focuses on ceramic, metal, and polymer biomaterials and their composites, both in micro and nano structural form.

This Special Issue will present new, valuable knowledge about biomaterials fabricated via novel or modified production techniques, which include not only new methods using, e.g., 3D printing, electrospinning, etc., but also conventional methods that have not been combined so far or can obtain biomaterials with new properties. This Special Issue will also to present the detailed physico-chemical, mechanical and biological characterization of biomaterials and their practical applications in regenerative medicine.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following: biomaterials with enhanced regenerative activity, biomaterials with antibacterial properties, biomaterials with anticancer properties, and biomaterials for diagnostics.

We look forward to receiving your contributions.

Dr. Katarzyna Klimek
Guest Editor

Dr. Julia Higuchi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ceramics
  • scaffolds
  • implants
  • polymers
  • metals
  • surface modification
  • electrospinnig
  • 3D printing
  • biomaterial characterization
  • regenerative medicine

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Published Papers (1 paper)

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Research

25 pages, 9472 KB  
Article
Alterations in the Physicochemical and Structural Properties of a Ceramic–Polymer Composite Induced by the Substitution of Hydroxyapatite with Fluorapatite
by Leszek Borkowski, Krzysztof Palka and Lukasz Pajchel
Materials 2025, 18(19), 4538; https://doi.org/10.3390/ma18194538 - 29 Sep 2025
Cited by 1 | Viewed by 790
Abstract
In recent years, apatite-based materials have garnered significant interest, particularly for applications in tissue engineering. Apatite is most commonly employed as a coating for metallic implants, as a component in composite materials, and as scaffolds for bone and dental tissue regeneration. Among its [...] Read more.
In recent years, apatite-based materials have garnered significant interest, particularly for applications in tissue engineering. Apatite is most commonly employed as a coating for metallic implants, as a component in composite materials, and as scaffolds for bone and dental tissue regeneration. Among its various forms, hydroxyapatite (HAP) is the most widely used, owing to its natural occurrence in human and animal hard tissues. An emerging area of research involves the use of fluoride-substituted apatite, particularly fluorapatite (FAP), which can serve as a direct fluoride source at the implant site, potentially offering several biological and therapeutic advantages. However, substituting HAP with FAP may lead to unforeseen changes in material behavior due to the differing physicochemical properties of these two calcium phosphate phases. This study investigates the effects of replacing hydroxyapatite with fluorapatite in ceramic–polymer composite materials incorporating β-1,3-glucan as a bioactive polymeric binder. The β-1,3-glucan polysaccharide was selected for its proven biocompatibility, biodegradability, and ability to form stable hydrogels that promote cellular interactions. Nitrogen adsorption analysis revealed that FAP/glucan composites had a significantly lower specific surface area (0.5 m2/g) and total pore volume (0.002 cm3/g) compared to HAP/glucan composites (14.15 m2/g and 0.03 cm3/g, respectively), indicating enhanced ceramic–polymer interactions in fluoride-containing systems. Optical profilometry measurements showed statistically significant differences in profile parameters (e.g., Rp: 134 μm for HAP/glucan vs. 352 μm for FAP/glucan), although average roughness (Ra) remained similar (34.1 vs. 27.6 μm, respectively). Microscopic evaluation showed that FAP/glucan composites had smaller particle sizes (1 μm) than their HAP counterparts (2 μm), despite larger primary crystal sizes in FAP, as confirmed by TEM. XRD analysis indicated structural differences between the apatites, with FAP exhibiting a reduced unit cell volume (524.6 Å3) compared to HAP (528.2 Å3), due to substitution of hydroxyl groups with fluoride ions. Spectroscopic analyses (FTIR, Raman, 31P NMR) confirmed chemical shifts associated with fluorine incorporation and revealed distinct ceramic–polymer interfacial behaviors, including an upfield shift of PO43− bands (964 cm−1 in FAP vs. 961 cm−1 in HAP) and OH vibration shifts (3537 cm−1 in FAP vs. 3573 cm−1 in HAP). The glucan polymer showed different hydrogen bonding patterns when combined with FAP versus HAP, as evidenced by shifts in polymer-specific bands at 888 cm−1 and 1157 cm−1, demonstrating that fluoride substitution significantly influences ceramic–polymer interactions in these bioactive composite systems. Full article
(This article belongs to the Special Issue Biomaterials for Regenerative Medicine: Synthesis, Characterization and Application)
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