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Cyclodextrin-Based Nanomaterials: Synthesis, Properties, and Applications
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Cyclodextrin-Based Nanomaterials: Synthesis, Properties, and Applications

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (15 July 2019) | Viewed by 8615

Special Issue Editors

Prof. Dr. Antonio Vargas-Berenguel

E-Mail Website
Guest Editor
Department of Chemistry and Physics, University of Almeria, 04120 Almeria, Spain
Interests: targeted nanocarriers for therapeutics; sensors for the detection of carbohydrate-lectin interactions; carbohydrates; neoglycoconjugates; glycoside multivalent effect–cyclodextrins: synthesis; supramolecular properties and applications; glycoside nanosystems based on plasmonic nanoparticles and metal organic frameworks
Special Issues, Collections and Topics in MDPI journals
Dr. Juan M. Casas-Solvas

E-Mail Website
Guest Editor
Department of Chemistry and Physics, University of Almeria, Carretera Sacramento S/N, 04120 Almeria, Spain
Interests: targeted drug nanocarriers; cyclodextrins; carbohydrates; multivalency; sensors; electrochemical sensors; nanoparticles; metal-organic frameworks; molecular recognition; binding constants determination
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cyclodextrins (CDs) are a family of cyclic oligosaccharides formed by six (α-CD), seven (β-CD) and eight (γ-CD) units of d-glucopyranosides that are linked through α-(1→4) bonds giving rise to torus-shaped structures having relatively hydrophobic cavities. CDs and their derivatives form complexes in aqueous solution with a large variety of organic molecules of hydrophobic nature and suitable size, by including them inside the cavity. Such host-guest abilities can be used for the aqueous solubilization of hydrophobic drugs and applied for designing drug delivery strategies. However, in recent years, their applications have been shown to go beyond such purpose as they can play a key role for the construction of new materials and/or provide interesting functional properties of a broad spectrum of applications, in particular in biomedical fields. For example, the guest hosting abilities can be applied for engineering supramolecular nanomaterials by the self-assembly between CD-containing and guest-containing polymers through supramolecular interactions. Alternatively, amphiphilic CD derivatives have been designed to build a variety of supramolecular self-assembled systems, such as micelles, vesicles and further nanoparticles. Both types of supramolecular materials have shown better biocompatibility and have been applied for designing enhanced efficient drug and gene delivery systems. On the other hand, functionalization of inorganic nanomaterials with CDs is a convenient  approach for imparting them drug loading abilities and thereby endowing the nanomaterials with drug delivery properties.

This special issue is devoted to presenting new work related with the above-mentioned topics and further developments. We kindly invite you to submit a manuscript discussing the preparation, the properties and applications of such new materials whose structure and/or functional properties are determined by the presence of CDs. Full papers, communications, and reviews covering the various aspects of cyclodextrin-based nanomaterials are welcome.

Prof. Antonio Vargas-Berenguel  
Dr. Juan M. Casas-Solvas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanomaterials
  • Sensors
  • Nanocarriers
  • Metal nanoparticles
  • Amphiphilic Cyclodextrins
  • Cyclodextrins
  • Supramolecular Nanoparticles
  • Supramolecular Polymers
  • Multifunctional Nanoparticles
  • Drug Delivery
  • Cyclodextrin Polymers
  • Smart Polymers
  • Self-Assembly

Published Papers (2 papers)

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Research

16 pages, 3100 KiB  
Article
Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation
by Blanca Lorenzo-Veiga, Hakon Hrafn Sigurdsson and Thorsteinn Loftsson
Materials 2019, 12(2), 229; https://doi.org/10.3390/ma12020229 - 11 Jan 2019
Cited by 20 | Viewed by 4412
Abstract
The topical administration route is commonly used for targeting therapeutics to the eye; however, improving the bioavailability of drugs applied directly to the eye remains a challenge. Different strategies have been studied to address this challenge. One of them is the use of [...] Read more.
The topical administration route is commonly used for targeting therapeutics to the eye; however, improving the bioavailability of drugs applied directly to the eye remains a challenge. Different strategies have been studied to address this challenge. One of them is the use of aggregates that are formed easily by self-assembly of cyclodextrin (CD)/drug complexes in aqueous solution. The aim of this study was to design a new eye drop formulation based on aggregates formed between CD/drug complexes. For this purpose, the physicochemical properties of the aggregates associated with six CDs and selected water-soluble polymers were analysed. Complex formation was studied using differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and 1H nuclear magnetic resonance spectroscopy (1H-NMR). Results showed that HPβCD performed best in terms of solubilization, while γCD performed best in terms of enhancing nanoaggregate formation. Formation of inclusion complexes was confirmed by DSC, FT-IR and 1H-NMR studies. A mixture of 15% (w/v) γCD and 8% (w/v) HPβCD was selected for formulation studies. It was concluded that formulations with aggregate sizes less than 1 µm and viscosity around 10–19 centipoises can be easily prepared using a mixture of CDs. Formulations containing polymeric drug/CD nanoaggregates represent an interesting strategy for enhanced topical delivery of nepafenac. Full article
(This article belongs to the Special Issue Cyclodextrin-Based Nanomaterials: Synthesis, Properties, and Applications)
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16 pages, 3808 KiB  
Article
2-Hydroxypropyl-β-Cyclodextrin Aggregates: Identification and Development of Analytical Techniques
by André Rodrigues Sá Couto, Alexey Ryzhakov and Thorsteinn Loftsson
Materials 2018, 11(10), 1971; https://doi.org/10.3390/ma11101971 - 13 Oct 2018
Cited by 14 | Viewed by 3631
Abstract
It is extremely important for pharmaceutical formulators to have analytical methodology that provides efficient detection and quantification of HPβCD aggregates. Five different methods were then evaluated for their potential to detect these aggregates and to determine critical aggregation concentration (cac): osmometry, viscometry, tensiometry, [...] Read more.
It is extremely important for pharmaceutical formulators to have analytical methodology that provides efficient detection and quantification of HPβCD aggregates. Five different methods were then evaluated for their potential to detect these aggregates and to determine critical aggregation concentration (cac): osmometry, viscometry, tensiometry, dynamic light scattering (DLS), and permeability studies. Overall, tensiometry was an inadequate method with which to study HPβCD aggregation, since the addition of HPβCD to water resulted in only minor changes in surface tension. Osmolality and viscosity studies have shown that for HPβCD, solute–solvent interactions are the main contributors for the observed deviation from ideality. These deviations might be related to the presence of aggregates. The DLS method proved to be an effective method with which to detect HPβCD aggregates and estimate their hydrodynamic diameter, although it presented some limitations concerning their quantification. In terms of the assessed methods, permeation studies were shown to be the best to study HPβCD aggregation phenomena, since they were the only method where the detection of aggregates and the determination of apparent cac values was possible. Also, it was the least invasive for the HPβCD samples and the method that provided more conclusive data. Results suggested that HPβCD, as expected, has less tendency to form aggregates than βCD. Full article
(This article belongs to the Special Issue Cyclodextrin-Based Nanomaterials: Synthesis, Properties, and Applications)
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