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New Advances in Electrochemical Biosensors
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New Advances in Electrochemical Biosensors

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 6835

Special Issue Editor

Dr. Luisa Pilan

E-Mail Website
Guest Editor
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 7 Gheorghe Polizu, 011061 Bucharest, Romania
Interests: electrochemical biosensors; electrochemical functionalization; carbon nanomaterials; conductive polymers; supercapacitors; corrosion
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

New advances in nanotechnology and biomolecular engineering have paved the way for the construction of novel and efficient biosensing systems in domains such as medical diagnosis, food safety, environmental monitoring, etc. The most widely used detection platforms are based on electrochemical transducers, mainly due to their sensitivity, low cost, and easy miniaturization. However, challenges such as the lowering of detection limit and the direct analysis within the sample matrix or long-term in vivo use still need to be solved before feasible commercial products can be designed. Interdisciplinary efforts in the synthesis of new functional nanomaterials combined with new advances in protein engineering and nucleic acid aptamers selection can support the current demands.

This Special Issue welcomes original research papers and reviews addressing the current progress in the development of electrochemical biosensors, from synthesis of new advanced nanomaterials for biosensing and engineering of their functional properties, to their integration with biological elements, designing of biosensing devices and evaluation of their performance. Of particular interest for this Special Issue will be the extension of these devices to real-time measurements and point-of-care biosensors.

Prof. Dr. Luisa Pilan
Guest Editor

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemical biosensors
  • DNA biosensors
  • immunosensors
  • enzyme biosensors
  • nanomaterials
  • functional materials
  • biorecognition
  • biomarkers
  • surface functionalization
  • point-of-care devices

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Published Papers (2 papers)

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16 pages, 4493 KiB  
Article
Electrochemical Non-Enzymatic Detection of Glucose Based on 3D Electroformed Copper on Ni Foam Nanostructures
by Gheorghe Melinte, Andreea Cernat, Aurora Petica, Oana Lazar, Marius Enachescu, Liana Anicai and Cecilia Cristea
Materials 2020, 13(12), 2752; https://doi.org/10.3390/ma13122752 - 17 Jun 2020
Cited by 11 | Viewed by 2993
Abstract
Despite the fact that the electrochemical biosensors based on glucose oxidase represent the golden standard for the management of diabetes, the elaboration of nonenzymatic sensors became extensively studied as an out-of-the-box concept that aims to simplify the existing approach. An important point of [...] Read more.
Despite the fact that the electrochemical biosensors based on glucose oxidase represent the golden standard for the management of diabetes, the elaboration of nonenzymatic sensors became extensively studied as an out-of-the-box concept that aims to simplify the existing approach. An important point of view is represented by the low price of the sensing device that has positive effects for both end-users and healthcare systems. The enzyme-free sensors based on low-cost materials such as transition metals have similar analytical properties to the commercial ones while eliminating the issues associated with the presence of the enzyme, such as the stability issues and limited shelf-life. The development of nanoporous nanomaterials for biomedical applications and electrocatalysis was referred to as an alternative to the conventional methods due to their enlarged area, electrical properties, ease of functionalization and not least to their low cost. Herein, we report the development of an electrochemical nonenzymatic sensor for glucose based on 3D copper nanostructures with Ni foams as promotor of the enhanced nanoporous morphology. The sensors were successfully tested in the presence of the designated target, even in the presence of common interference agents found in biological samples. Full article
(This article belongs to the Special Issue New Advances in Electrochemical Biosensors)
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Review

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39 pages, 5858 KiB  
Review
The Role of Aryldiazonium Chemistry in Designing Electrochemical Aptasensors for the Detection of Food Contaminants
by Matei Raicopol and Luisa Pilan
Materials 2021, 14(14), 3857; https://doi.org/10.3390/ma14143857 - 10 Jul 2021
Cited by 11 | Viewed by 2968
Abstract
Food safety monitoring assays based on synthetic recognition structures such as aptamers are receiving considerable attention due to their remarkable advantages in terms of their ability to bind to a wide range of target analytes, strong binding affinity, facile manufacturing, and cost-effectiveness. Although [...] Read more.
Food safety monitoring assays based on synthetic recognition structures such as aptamers are receiving considerable attention due to their remarkable advantages in terms of their ability to bind to a wide range of target analytes, strong binding affinity, facile manufacturing, and cost-effectiveness. Although aptasensors for food monitoring are still in the development stage, the use of an electrochemical detection route, combined with the wide range of materials available as transducers and the proper immobilization strategy of the aptamer at the transducer surface, can lead to powerful analytical tools. In such a context, employing aryldiazonium salts for the surface derivatization of transducer electrodes serves as a simple, versatile and robust strategy to fine-tune the interface properties and to facilitate the convenient anchoring and stability of the aptamer. By summarizing the most important results disclosed in the last years, this article provides a comprehensive review that emphasizes the contribution of aryldiazonium chemistry in developing electrochemical aptasensors for food safety monitoring. Full article
(This article belongs to the Special Issue New Advances in Electrochemical Biosensors)
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