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Biomaterials for Controlling Inflammation and Wound Healing

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 3558

Special Issue Editor


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Guest Editor
Department of Integrated Biomedical Science, Soonchunhyang University, Asan-si 31538, Republic of Korea
Interests: biomaterials; 3D bioprinting; extracellular matrix remodeling; stem cell fate determination; organ-on-a-chip models
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Special Issue Information

Dear Colleagues,

In normal physiological conditions, well-orchestrated inflammatory responses have shown to regulate wound healing and tissue repair by the spatiotemporal modulatiton of various immune-responsible cell types, including dendritic cells, neutrophils, monocytes, macrophages, T cells, B cells, fibroblasts, myofibroblasts, and other cells presented within host tissues. To accelerate wound healing processes, functional biomaterials have emerged as potential candidates to provide 3D structural support to the transplanted cells and their microenvironments and to recapitulate biomechanical and biochemical extracellular cues. However, proper controlling of both innate and adaptive immune systems to avoid prolonged inflammation or fibrotic foreign body reactions is still a challenging task.

This Special Issue of Materials, entitled "Biomaterials for Controlling Inflammation and Wound Healing", will cover a broad range of the most exciting research topics, addressing recent findings and advancements on the synthesis of biomimetic polymers, preparation of 3D biomimetic scaffolds, biomimetic matrix-mediated macrophage polarization/regulation and in vivo tissue regeneration, development of biomimetic polymer-based bioinks for 3D printing, etc., which aim to achieve a bioengineered microenvironment for macrophage polarization and functional tissue regeneration. This Special Issue welcomes original research articles, short communications, and review articles.

Prof. Yongsung Hwang
Guest Editor

Manuscript Submission Information

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Keywords

  • biomimetic polymers
  • 3D printing
  • 3D scaffolds
  • Wound healing
  • Immune responses
  • Macrophage polarization
  • Foreign body reactions
  • Tissue engineering
  • Regenerative medicine
  • Bioinks
  • Hydrogels
  • Fibroblasts

Published Papers (1 paper)

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Research

10 pages, 3538 KiB  
Article
Effects of Substrate-Coating Materials on the Wound-Healing Process
by Jin-Young Lin, Kai-Yin Lo and Yung-Shin Sun
Materials 2019, 12(17), 2775; https://doi.org/10.3390/ma12172775 - 29 Aug 2019
Cited by 8 | Viewed by 3145 | Correction
Abstract
The wound-healing assay is commonly and widely used for investigating collective cell migration under various physical and chemical stimuli. Substrate-coating materials are shown to affect the wound-healing process in a cell-type dependent manner. However, experiment-to-experiment variations make it difficult to compare results from [...] Read more.
The wound-healing assay is commonly and widely used for investigating collective cell migration under various physical and chemical stimuli. Substrate-coating materials are shown to affect the wound-healing process in a cell-type dependent manner. However, experiment-to-experiment variations make it difficult to compare results from different assays. In this paper, a modified barrier wound-healing assay was reported for studying the wound-healing process on different substrates in one single petri dish. In short, half of a dish was covered with the tape, and coating materials, poly-l-lysine and gelatin, were applied to the surface. After peeling off the tape, half of the surface was coated with the desired material. Then a customized barrier was placed inside the dish to create the wound. The results indicated that surface coating did not affect cell proliferation/viability, and the wound-healing rate increased in coated surfaces compared to uncoated ones. The present study provides a platform for further understanding the mechanisms of substrate coating-dependent wound-healing processes. Full article
(This article belongs to the Special Issue Biomaterials for Controlling Inflammation and Wound Healing)
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