Multiple Layers of Stress-Induced Regulation in tRNA Biology
AbstracttRNAs are the fundamental components of the translation machinery as they deliver amino acids to the ribosomes during protein synthesis. Beyond their essential function in translation, tRNAs also function in regulating gene expression, modulating apoptosis and several other biological processes. There are multiple layers of regulatory mechanisms in each step of tRNA biogenesis. For example, tRNA 3′ trailer processing is altered upon nutrient stress; tRNA modification is reprogrammed under various stresses; nuclear accumulation of tRNAs occurs upon nutrient deprivation; tRNA halves accumulate upon oxidative stress. Here we address how environmental stresses can affect nearly every step of tRNA biology and we describe the possible regulatory mechanisms that influence the function or expression of tRNAs under stress conditions. View Full-Text
Share & Cite This Article
Huang, H.-Y.; Hopper, A.K. Multiple Layers of Stress-Induced Regulation in tRNA Biology. Life 2016, 6, 16.
Huang H-Y, Hopper AK. Multiple Layers of Stress-Induced Regulation in tRNA Biology. Life. 2016; 6(2):16.Chicago/Turabian Style
Huang, Hsiao-Yun; Hopper, Anita K. 2016. "Multiple Layers of Stress-Induced Regulation in tRNA Biology." Life 6, no. 2: 16.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.