Novel Pharmacological Approaches to the Treatment of Depression

Dear Colleagues,

Depression is a common chronic neuropsychiatric disorder highly prevalent in Western countries. It can affect people of all ages, genders, racial/ethnic/cultural backgrounds. Depression negatively influences quality of life of an individual but it also belongs to the largest contributors to global disability and suicide deaths. Though there are several therapeutic options for depression, management of this disease is still challenging. Clinical efficiency of the available antidepressant drugs is not sufficient since a number of patients with depression do not respond to the prescribed therapy, do not achieve complete remission, and they suffer relapses. Furthermore, conventional antidepressants may induce bothersome side effects that can result in patients non-compliance. Therefore, constant attempts have been made to develop new, more effective agents or treatment strategies with faster onset of the antidepressant effect and better safety profile. Research teams focus on novel compounds but also they evaluate unique combinations of known substances with an antidepressant potential. Simultaneously, intensive studies on the pathomechanism of depressive disorders have been carried out in order to identify innovative drug targets. In this Special Issue on Novel Pharmacological Approaches to the Treatment of Depression we would like to bring together experts working in the depression field and invite them to present their recent results from both pre-clinical and clinical studies related to pharmacotherapy of depressive disorders. Review articles and short communications on the latest achievements in the management of depression would be also welcome.

You may choose our Joint Special Issue in Psych.

Dr. Anna Serefko
Prof. Dr. Ewa Poleszak
Dr. Aleksandra Szopa
Guest Editors

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