Influence of Smallanthus sonchifolius (Yacon) on the Activity of Antidepressant Drugs in Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Plant Material
2.2. Accelerated Solvent Extraction
2.3. Drugs Administration
2.4. Animals
2.5. Forced Swim Test (FST)
2.6. Spontaneous Locomotor Activity
2.7. Statistical Analysis
3. Results
3.1. Effects of an Acute Administration of Yacon Tuber Extract in the FST in Mice
3.2. Effects of a Combined Administration of the Effective Doses of Yacon Tuber Extract and Antidepressants in the FST in Mice
3.3. Effects of a Combined Administration of the Sub-Effective Doses of Yacon Tuber Extract and Antidepressants in the FST in Mice
- (A)
- A significant Yacon-imipramine interaction (F(1,34) = 5.59, p = 0.0240) with a significant effect of imipramine (F(1,34) = 25.12, p < 0.0001) and a significant effect of the Yacon extract (F(1,34) = 4.25, p = 0.0469);
- (B)
- A significant Yacon-fluoxetine interaction (F(1,36) = 6.26, p = 0.0170) with a significant effect of fluoxetine (F(1,36) = 10.49, p = 0.0026) and a not significant effect of the Yacon extract (F(1,36) = 3.78, p = 0.0598);
- (C)
- A significant Yacon-reboxetine interaction (F(1,35) = 4.79, p = 0.0355) with a significant effect of reboxetine (F(1,35) = 27.37, p < 0.0001) and a not significant effect of the Yacon extract (F(1,35) = 3.35, p = 0.0758).
3.4. Effects of an Acute Administration of Yacon Tuber Extract on the Spontaneous Locomotor Activity of Mice
3.5. Effects of a Combined Administration of the Effective Doses of Yacon Tuber Extract and Antidepressants on the Spontaneous Locomotor Activity of Mice
- (A)
- Not significant effect of imipramine (F(1,32) = 0,02, p = 0.8779), not significant effect of the Yacon extract (F(1,32) = 0.27, p = 0.6094), and no Yacon-imipramine interaction (F(1,32) = 2.65, p = 0.1136);
- (B)
- Not significant effect of fluoxetine (F(1,32) = 1.40, p = 0.2458), not significant effect of the Yacon extract (F(1,32) = 0.26, p = 0.6158), and no Yacon-fluoxetine interaction (F(1,32) = 0.76, p = 0.3884);
- (C)
- Not significant effect of reboxetine (F(1,34) = 2.37, p = 0.1329), not significant effect of the Yacon extract (F(1,34) = 0.22, p = 0.6448), and no Yacon-reboxetine interaction (F(1,34) = 1.55, p = 0.2222).
3.6. Effects of a Combined Administration of the Sub-Effective Doses of Yacon Tuber Extract and Antidepressants on the Spontaneous Locomotor Activity of Mice
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- World Health Organization. Depression and Other Common Mental Disorders: Global Health Estimate; World Health Organization: Geneva, Switzerland, 2017. [Google Scholar]
- World Health Organization. Depression and Other Common Mental Disorders: Global Health Estimate; World Health Organization: Geneva, Switzerland, 2012. [Google Scholar]
- Kuhn, R. Treatment of depressive states with an iminodibenzyl derivative (G 22355). Schweiz. Med. Wochenschr. 1957, 87, 1135–1140. [Google Scholar] [PubMed]
- Rush, A. Limitations in efficacy of antidepressant monotherapy. J. Clin. Psychiatry 2007, 68, 8–10. [Google Scholar]
- Nutt, D.J.; Davidson, J.R.T.; Gelenberg, A.J.; Higuchi, T.; Kanba, S.; Karamustafalıoğlu, O.; Papakostas, G.I.; Sakamoto, K.; Terao, T.; Zhang, M. International Consensus Statement on Major Depressive Disorder. J. Clin. Psychiatry 2010, 71, e08. [Google Scholar] [CrossRef]
- Penn, E.; Tracy, D.K. The drugs don’t work? Antidepressants and the current and future pharmacological management of depression. Ther. Adv. Psychopharmacol. 2012, 2, 179–188. [Google Scholar] [CrossRef] [Green Version]
- De Almeida Paula, H.A.; Abranches, M.V.; de Luces Fortes Ferreira, C.L. Yacon (Smallanthus sonchifolius): A food with multiple functions. Crit. Rev. Food Sci. Nutr. 2015, 55, 32–40. [Google Scholar] [CrossRef]
- Da Silva Almeida, A.P.; Avi, C.M.; Barbisan, L.F.; de Moura, N.A.; Caetano, B.F.R.; Romualdo, G.R.; Sivieri, K. Yacon (Smallanthus sonchifolius) and Lactobacillus acidophilus CRL 1014 reduce the early phases of colon carcinogenesis in male Wistar rats. Food Res. Int. 2015, 74, 48–54. [Google Scholar] [CrossRef] [PubMed]
- Delgado, G.T.C.; Thomé, R.; Gabriel, D.L.; Tamashiro, W.M.; Pastore, G.M. Yacon (Smallanthus sonchifolius)-derived fructooligosaccharides improves the immune parameters in the mouse. Nutr. Res. 2012, 32, 884–892. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Sousa, S.; Pinto, J.; Rodrigues, C.; Gião, M.; Pereira, C.; Tavaria, F.; Malcata, F.; Gomes, A.; Pacheco, M.; Pintado, M. Antioxidant properties of sterilized yacon (Smallanthus sonchifolius) tuber flour. Food Chem. 2015, 188, 504–509. [Google Scholar] [CrossRef]
- Valentová, K.; Stejskal, D.; Bartek, J.; Dvořáčková, S.; Křen, V.; Ulrichová, J.; Šimánek, V. Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: In vivo safety assessment. Food Chem. Toxicol. 2008, 46, 1006–1013. [Google Scholar] [CrossRef]
- Vasconcelos, C.M.; Silva, C.B.D.; Teixeira, L.J.Q.; Chaves, J.B.P.; Martino, H.S.D. Determinaçăo da fraçăo da fibra alimentar solúvel em raiz e farinha de yacon (Smallanthus sonchifolius) pelo método enzimático-gravimétrico e cromatografia líquida de alta eficięncia. Rev. Inst. Adolfo Lutz. 2010, 69, 1–16. [Google Scholar]
- Joung, H.; Kwon, N.-Y.; Choi, J.-G.; Shin, D.-Y.; Chun, S.-S.; Yu, Y.-B.; Shin, N.-W. Antibacterial and synergistic effects of Smallanthus sonchifolius leaf extracts against methicillin-resistant Staphylococcus aureus under light intensity. J. Nat. Med. 2010, 64, 212–215. [Google Scholar] [CrossRef] [PubMed]
- Lin, F.; Hasegawa, M.; Kodama, O. Purification and Identification of Antimicrobial Sesquiterpene Lactones from Yacon (Smallanthus sonchifolius) Leaves. Biosci. Biotechnol. Biochem. 2003, 67, 2154–2159. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Vargas-Tineo, O.W.; Segura-Munoz, D.M.; Becerra-Gutiérrez, L.K.; Amado-Tineo, J.P.; Silva-Diaz, H. Hypoglycemic effect of Moringa oleifera (moringa) compared with Smallanthus sonchifolius (yacon) on Rattus norvegicus with induced diabetes mellitus. Rev. Peru Med. Exp. Salud Publica 2020, 37, 478–484. [Google Scholar] [CrossRef] [PubMed]
- Honoré, S.M.; Grande, M.V.; Rojas, J.G.; Sánchez, S.S. Smallanthus sonchifolius (Yacon) Flour Improves Visceral Adiposity and Metabolic Parameters in High-Fat-Diet-Fed Rats. J. Obes. 2018, 2018, 1–15. [Google Scholar] [CrossRef] [PubMed]
- Lee, K.P.; Choi, N.H.; Kim, J.T.; Park, I.-S. The effect of yacon (Samallanthus sonchifolius) ethanol extract on cell proliferation and migration of C6 glioma cells stimulated with fetal bovine serum. Nutr. Res. Pract. 2015, 9, 256–261. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Myint, P.P.; Dao, T.T.P.; Kim, Y.S. Anticancer Activity of Smallanthus sonchifolius Methanol Extract against Human Hepatocellular Carcinoma Cells. Molecules 2019, 24, 3054. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ambriz-Pérez, D.L.; Leyva-López, N.; Gutierrez-Grijalva, E.P.; Heredia, J.B. Phenolic compounds: Natural alternative in inflammation treatment. A Review. Cogent Food Agric. 2016, 2, 1131412. [Google Scholar]
- Da Silva, S.T.; dos Santos, C.A.; Bressan, J. Intestinal microbiota; relevance to obesity and modulation by prebiotics and probiotics. Nutr. Hosp. 2013, 28, 1039–1048. [Google Scholar]
- Liu, F.; Prabhakar, M.; Ju, J.; Long, H.; Zhou, H.-W. Effect of inulin-type fructans on blood lipid profile and glucose level: A systematic review and meta-analysis of randomized controlled trials. Eur. J. Clin. Nutr. 2017, 71, 9–20. [Google Scholar] [CrossRef]
- Russo, D.; Valentão, P.; Andrade, P.B.; Fernandez, E.C.; Milella, L. Evaluation of Antioxidant, Antidiabetic and Anticholinesterase Activities of Smallanthus sonchifolius Landraces and Correlation with Their Phytochemical Profiles. Int. J. Mol. Sci. 2015, 16, 17696–17718. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Genta, S.B.; Cabrera, W.M.; Habib, N.C.; Pons, J.; Carillo, I.M.; Grau, A.; Sánchez, S. Yacon syrup: Beneficial effects on obesity and insulin resistance in humans. Clin. Nutr. 2009, 28, 182–187. [Google Scholar] [CrossRef]
- Vaz-Tostes, M.D.G.; Viana, M.L.; Grancieri, M.; Luz, T.C.D.S.; de Paula, H.; Pedrosa, R.G.; Costa, N.M.B. Yacon effects in immune response and nutritional status of iron and zinc in preschool children. Nutrition 2014, 30, 666–672. [Google Scholar] [CrossRef]
- Scheid, M.M.A.; Genaro, P.S.; Moreno, Y.M.F.; Pastore, G.M. Freeze-dried powdered yacon: Effects of FOS on serum glucose, lipids and intestinal transit in the elderly. Eur. J. Nutr. 2014, 53, 1457–1464. [Google Scholar] [CrossRef]
- Machado, A.M.; da Silva, N.B.M.; Chaves, J.B.P.; Alfenas, R.C.G. Consumption of yacon flour improves body composition and intestinalfunction in overweight adults: A randomized, double-blind, placebo-controlled clinical trial. Clin. Nutr. ESPEN 2019, 29, 22–29. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Silva, M.D.F.G.D.; Dionísio, A.P.; Carioca, A.A.F.; Adriano, L.S.; Pinto, C.O.; de Abreu, F.A.P.; Wurlitzer, N.J.; Araújo, I.M.; Garruti, D.D.S.; Pontes, D.F. Yacon syrup: Food applications and impact on satiety in healthy volunteers. Food Res. Int. 2017, 100, 460–467. [Google Scholar] [CrossRef] [PubMed]
- De Souza Lima Sant’Anna, M.; Rodrigues, V.C.; Araújo, T.F.; de Oliveira, T.T.; do Carmo Gouveia Peluzio, M.; Ferreira, C.L.D.L.F. Yacon-Based Product in the Modulation of Intestinal Constipation. J. Med. Food 2015, 18, 980–986. [Google Scholar] [CrossRef]
- An, L.; Yang, J.-C.; Yin, H.; Xue, R.; Wang, Q.; Sun, Y.C.; Zhang, Y.-Z.; Yang, M. Inulin-Type Oligosaccharides Extracted from Yacon Produce Antidepressant-Like Effects in Behavioral Models of Depression. Phytotherapy Res. 2016, 30, 1937–1942. [Google Scholar] [CrossRef] [PubMed]
- Zhang, Z.-Q.; Yuan, L.; Yang, M.; Luo, Z.-P.; Zhao, Y.-M. The effect of Morinda officinalis: How, a Chinese traditional medicinal plant, on the DRL 72-s schedule in rats and the forced swimming test in mice. Pharmacol. Biochem. Behav. 2002, 72, 39–43. [Google Scholar] [CrossRef]
- Zhang, Y.Z.; Li, Y.F.; Liu, G.; Li, Y.; Huang, S.J.; Luo, Z.P. Antidepressant effect of oligosaccharides extracted from Morinda officinal is on the learned helplessness rat model. Chin. J. Behav. Med. Sci. 2005, 14, 309–311. [Google Scholar]
- Li, Y.-F.; Liu, Y.-Q.; Yang, M.; Wang, H.-L.; Huang, W.-C.; Zhao, Y.-M.; Luo, Z.-P. The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone. Life Sci. 2004, 75, 1531–1538. [Google Scholar] [CrossRef]
- Costa, G.; Vasconcelos, Q.; Abreu, G.; Albuquerque, A.; Vilar, J.; Aragão, G. Systematic review of the ingestion of fructooligosaccharides on the absorption of minerals and trace elements versus control groups. Clin. Nutr. ESPEN 2021, 41, 68–76. [Google Scholar] [CrossRef] [PubMed]
- Colla, A.R.; Oliveira, A.; Pazini, F.L.; Rosa, J.M.; Manosso, L.M.; Cunha, M.P.; Rodrigues, A.L.S. Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice. Pharmacol. Biochem. Behav. 2014, 124, 108–116. [Google Scholar] [CrossRef] [Green Version]
- Müller, L.G.; Salles, L.A.; Stein, A.C.; Betti, A.H.; Sakamoto, S.; Cassel, E.; Vargas, R.F.; von Poser, G.L.; Rates, S.M. Antidepressant-like effect of Valeriana glechomifolia Meyer (Valerianaceae) in mice. Prog. Neuro-Psychopharmacology Biol. Psychiatry 2012, 36, 101–109. [Google Scholar] [CrossRef] [Green Version]
- Shimamura, M.; Kobayashi, T.; Kuratani, K.; Kinoshita, M. Optimized analysis of the forced swim test using an automated experimental system: Detailed time course study in mice. J. Pharmacol. Toxicol. Methods 2008, 57, 80–84. [Google Scholar] [CrossRef]
- Ishola, I.; Chatterjee, M.; Tota, S.; Tadigopulla, N.; Adeyemi, O.O.; Palit, G.; Shukla, R. Antidepressant and anxiolytic effects of amentoflavone isolated from Cnestis ferruginea in mice. Pharmacol. Biochem. Behav. 2012, 103, 322–331. [Google Scholar] [CrossRef] [PubMed]
- Porsolt, R.D.; Le Pichon, M.; Jalfre, M. Depression: A new animal model sensitive to antidepressant treatments. Nature 1977, 266, 730–732. [Google Scholar] [CrossRef]
- Poleszak, E.; Szopa, A.; Wyska, E.; Kukuła-Koch, W.; Serefko, A.; Wośko, S.; Bogatko, K.; Wróbel, A.; Wlaź, P. Caffeine augments the antidepressant-like activity of mianserin and agomelatine in forced swim and tail suspension tests in mice. Pharmacol. Rep. 2016, 68, 56–61. [Google Scholar] [CrossRef]
- Yan, M.R.; Welch, R.; Rush, E.C.; Xiang, X.; Wang, X. A Sustainable Wholesome Foodstuff; Health Effects and Potential Dietotherapy Applications of Yacon. Nutrients 2019, 11, 2632. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Machado, A.M.; Da Silva, N.B.M.; De Freitas, R.M.P.; De Freitas, M.B.D.; Chaves, J.B.P.; Oliveira, L.L.; Martino, H.S.D.; Alfenas, R.D.C.G. Effects of yacon flour associated with an energy restricted diet on intestinal permeability, fecal short chain fatty acids, oxidative stress and inflammation markers levels in adults with obesity or overweight: A randomized, double blind, placebo controlled clinical trial. Arch. Endocrinol. Metab. 2020, 64, 597–607. [Google Scholar] [CrossRef] [Green Version]
- Yun, E.Y.; Kim, H.S.; Kim, Y.E.; Kang, M.K.; Ma, J.E.; Lee, G.D.; Cho, Y.J.; Kim, H.C.; Lee, J.D.; Hwang, Y.S.; et al. A Case of Anaphylaxis after the Ingestion of Yacon. Allergy Asthma Immunol. Res. 2010, 2, 149–152. [Google Scholar] [CrossRef] [Green Version]
- Cryan, J.F.; Mombereau, C.; Vassout, A. The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 2005, 29, 571–625. [Google Scholar] [CrossRef]
- Porsolt, R.D.; Lenegre, A. Behavioral models of depression. In Experimental Approaches to Anxiety and Depression; Elliot, J.M., Heal, D.J., Marsden, C.A., Eds.; Willey: New York, NY, USA, 1992; pp. 73–85. [Google Scholar]
- Poleszak, E.; Szopa, A.; Bogatko, K.; Wyska, E.; Wośko, S.; Świąder, K.; Doboszewska, U.; Wlaź, A.; Wróbel, A.; Wlaź, P.; et al. Antidepressant-Like Activity of Typical Antidepressant Drugs in the Forced Swim Test and Tail Suspension Test in Mice Is Augmented by DMPX, an Adenosine A2A Receptor Antagonist. Neurotox. Res. 2019, 35, 344–352. [Google Scholar] [CrossRef] [Green Version]
- Poleszak, E.; Wośko, S.; Sławińska, K.; Wyska, E.; Szopa, A.; Doboszewska, U.; Wlaź, P.; Wlaź, A.; Dudka, J.; Szponar, J.; et al. Influence of the CB1 cannabinoid receptors on the activity of the monoaminergic system in the behavioural tests in mice. Brain Res. Bull. 2019, 150, 179–185. [Google Scholar] [CrossRef] [PubMed]
- Poleszak, E.; Wośko, S.; Sławińska, K.; Wyska, E.; Szopa, A.; Sobczyński, J.; Wróbel, A.; Doboszewska, U.; Wlaź, P.; Wlaź, A.; et al. Ligands of the CB2 cannabinoid receptors augment activity of the conventional antidepressant drugs in the behavioural tests in mice. Behav. Brain Res. 2020, 378, 112297. [Google Scholar] [CrossRef]
- Szopa, A.; Doboszewska, U.; Herbet, M.; Wośko, S.; Wyska, E.; Świąder, K.; Serefko, A.; Korga, A.; Wlaź, A.; Wróbel, A.; et al. Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt, Slc6a15 and Adora1 gene expression. Toxicol. Appl. Pharmacol. 2017, 337, 95–103. [Google Scholar] [CrossRef]
- Szopa, A.; Poleszak, E.; Bogatko, K.; Wyska, E.; Wośko, S.; Doboszewska, U.; Świąder, K.; Wlaź, A.; Dudka, J.; Wróbel, A.; et al. DPCPX, a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests. Naunyn-Schmiedeberg’s Arch. Pharmacol. 2018, 391, 1361–1371. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bhatt, S.; Nagappa, A.N.; Patil, C. Role of oxidative stress in depression. Drug Discov. Today 2020, 25, 1270–1276. [Google Scholar] [CrossRef] [PubMed]
- Afridi, R.; Suk, K. Neuroinflammatory Basis of Depression: Learning From Experimental Models. Front. Cell. Neurosci. 2021, 15, 691067. [Google Scholar] [CrossRef]
- Knudsen, J.K.; Bundgaard-Nielsen, C.; Hjerrild, S.; Nielsen, R.E.; Leutscher, P.; Sørensen, S. Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review. Brain Behav. 2021, 11, e02177. [Google Scholar] [CrossRef]
- Habib, N.C.; Serra-Barcellona, C.; Honoré, S.M.; Genta, S.B.; Sánchez, S.S. Yacon roots (Smallanthus sonchifolius) improve oxidative stress in diabetic rats. Pharm. Biol. 2015, 53, 1183–1193. [Google Scholar] [CrossRef]
- Baek, S.; Choi, N.H.; Lee, K.-P.; Jhun, H.; Kim, J. Smallanthus sonchifolius leaf attenuates neuroinflammation. J. Exerc. Nutr. Biochem. 2018, 22, 31–35. [Google Scholar] [CrossRef] [PubMed]
- Verediano, T.A.; Viana, M.L.; das Garcas Vaz Tostes, M.; De Oliveira, D.S.; de Carvalho Nunes, L.D.C.; Costa, N.M.B. Yacón (Smallanthus sonchifolius) prevented inflammation, oxidative stress, and intestinal alterations in an animal model of colorectal carcinogenesis. J. Sci. Food Agric. 2020, 100, 5442–5449. [Google Scholar] [CrossRef] [PubMed]
- Wong, J.M.W.; de Souza, R.; Kendall, C.W.C.; Emam, A.; Jenkins, D.J.A. Colonic Health: Fermentation and Short Chain Fatty Acids. J. Clin. Gastroenterol. 2006, 40, 235–243. [Google Scholar] [CrossRef] [PubMed]
- Van der Beek, C.M.; Canfora, E.E.; Kip, A.M.; Gorissen, S.H.; Damink, S.W.O.; van Eijk, H.M.; Holst, J.J.; Blaak, E.E.; Dejong, C.H.; Lenaerts, K. The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men. Metabolism 2018, 87, 25–35. [Google Scholar] [CrossRef]
- Bonet, M.B.; Meson, O.; de Moreno de Leblanc, A.d.M.d.; Dogi, C.; Chaves, S.; Kortsarz, A.; Grau, A.; Perdigon, G.; Chaves, A.S. Prebiotic effect of yacon (Smallanthus sonchifolius) on intestinal mucosa using a mouse model. Food Agric. Immunol. 2010, 21, 175–189. [Google Scholar] [CrossRef]
- Velez, E.; Castillo, N.; Mesón, O.; Grau, A.; Bonet, M.E.B.; Perdigón, G. Study of the effect exerted by fructo-oligosaccharides from yacon (Smallanthus sonchifolius) root flour in an intestinal infection model with Salmonella Typhimurium. Br. J. Nutr. 2013, 109, 1971–1979. [Google Scholar] [CrossRef] [Green Version]
- Martino, H.S.D.; Kolba, N.; Tako, E. Yacon (Smallanthus sonchifolius) flour soluble extract improve intestinal bacterial populations, brush border membrane functionality and morphology in vivo (Gallus gallus). Food Res. Int. 2020, 137, 109705. [Google Scholar] [CrossRef]
- Campos, D.; Pallardel, I.M.B.; Chirinos, R.; Galvez, A.C.A.; Noratto, G.; Pedreschi, R. Prebiotic effects of yacon (Smallanthus sonchifolius Poepp. & Endl), a source of fructooligosaccharides and phenolic compounds with antioxidant activity. Food Chem. 2012, 135, 1592–1599. [Google Scholar] [CrossRef]
- Aizawa, E.; Tsuji, H.; Asahara, T.; Takahashi, T.; Teraishi, T.; Yoshida, S.; Ota, M.; Koga, N.; Hattori, K.; Kunugi, H. Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder. J. Affect. Disord. 2016, 202, 254–257. [Google Scholar] [CrossRef]
- Kazemi, A.; Noorbala, A.A.; Azam, K.; Eskandari, M.H.; Djafarian, K. Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clin. Nutr. 2019, 38, 522–528. [Google Scholar] [CrossRef]
- Moludi, J.; Alizadeh, M.; Mohammadzad, M.H.S.; Davari, M. The Effect of Probiotic Supplementation on Depressive Symptoms and Quality of Life in Patients after Myocardial Infarction: Results of a Preliminary Double-Blind Clinical Trial. Psychosom. Med. 2019, 81, 770–777. [Google Scholar] [CrossRef] [PubMed]
- Pinto-Sanchez, M.I.; Hall, G.B.; Ghajar, K.; Nardelli, A.; Bolino, C.; Lau, J.T.; Martin, F.-P.; Cominetti, O.; Welsh, C.; Rieder, A.; et al. Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology 2017, 153, 448–459.e8. [Google Scholar] [CrossRef] [PubMed]
- Slykerman, R.; Hood, F.; Wickens, K.; Thompson, J.; Barthow, C.; Murphy, R.; Kang, J.; Rowden, J.; Stone, P.; Crane, J.; et al. Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial. EBioMedicine 2017, 24, 159–165. [Google Scholar] [CrossRef] [PubMed] [Green Version]
Treatment (mg/kg) | Traveled Distance (cm) | Number of Animals Per Group |
---|---|---|
Saline | 484.0 ± 56.78 | 10 |
Yacon 25 | 462.3 ± 57.72 | 10 |
Yacon 50 | 429.3 ± 53.96 | 10 |
Yacon 100 | 550.0 ± 51.22 | 10 |
Imipramine 15 | 525.0 ± 65.21 | 10 |
Treatment (mg/kg) | Traveled Distance (cm) | Number of Animals Per Group |
---|---|---|
Saline + saline | 519.80 ± 46.3 | 10 |
Yacon 100 + saline | 590.70 ± 23.7 | 10 |
Imipramine 15 + saline | 568.50 ± 24.2 | 8 |
Yacon 100 + imipramine 15 | 531.75 ± 24.9 | 8 |
Fluoxetine 40 + saline | 504.00 ± 61.6 | 8 |
Yacon 100 + fluoxetine 40 | 485.12 ± 72.3 | 8 |
Reboxetine 10 + saline | 507.50 ± 46.5 | 8 |
Yacon 100 + reboxetine 10 | 475.20 ± 45.5 | 10 |
Treatment (mg/kg) | Traveled Distance (cm) | Number of Animals Per Group |
---|---|---|
Saline + saline | 517.30 ± 46.9 | 10 |
Yacon 50 + saline | 522.40 ± 64.1 | 10 |
Imipramine 7.5 + saline | 523.87 ± 39.0 | 8 |
Yacon 50 + imipramine 7.5 | 562.00 ± 22.3 | 9 |
Fluoxetine 20 + saline | 451.40 ± 45.1 | 10 |
Yacon 50 + fluoxetine 20 | 495.30 ± 22.5 | 10 |
Reboxetine 5 + saline | 362.80 ± 32.5 | 10 |
Yacon 50 + reboxetine 5 | 381.30 ± 31.3 | 10 |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Wośko, S.; Serefko, A.; Szopa, A.; Kardaś, S.; Widelski, J.; Mroczek, T.; Rostkowska, E.; Szymańska, J.; Poleszak, E. Influence of Smallanthus sonchifolius (Yacon) on the Activity of Antidepressant Drugs in Mice. Life 2021, 11, 1117. https://doi.org/10.3390/life11111117
Wośko S, Serefko A, Szopa A, Kardaś S, Widelski J, Mroczek T, Rostkowska E, Szymańska J, Poleszak E. Influence of Smallanthus sonchifolius (Yacon) on the Activity of Antidepressant Drugs in Mice. Life. 2021; 11(11):1117. https://doi.org/10.3390/life11111117
Chicago/Turabian StyleWośko, Sylwia, Anna Serefko, Aleksandra Szopa, Sylwia Kardaś, Jarosław Widelski, Tomasz Mroczek, Ewelina Rostkowska, Jolanta Szymańska, and Ewa Poleszak. 2021. "Influence of Smallanthus sonchifolius (Yacon) on the Activity of Antidepressant Drugs in Mice" Life 11, no. 11: 1117. https://doi.org/10.3390/life11111117