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Personalized Diagnostics and Therapeutics for Head and Neck Surgery

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A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 5123

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Special Issue Editor

Prof. Dr. Frank Wilde

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Guest Editor

Department of Cranio-Maxillo-Facial-Surgery, University Hospital Ulm, 89081 Ulm, Germany
Interests: computed tomography; oral diseases; surgery; diagnostic imaging; fracture; oral surgery; dental implantology; implant dentistry

Special Issue Information

Dear Colleagues,

In recent years, advances in computer-assisted surgery have made it increasingly possible to offer personalized reconstructions to patients undergoing head and neck surgery. Reconstructions with patient-specific implants and surgical templates must be mentioned specifically in this context. In this respect, further developments should now focus on decreasing the workflow and, above all, increasing user friendliness and the faster availability of individual solutions.

However, new knowledge in the field of personalized diagnostics with regard to potential prognostic factors and personalized (non-)surgical therapy approaches for head and neck oncology is an exciting and forward-looking topic of research.

With this Special Issue, authors are invited to present their most recent developments and findings in personalized diagnostics and therapy in the field of head and neck surgery.

Prof. Dr. Frank Wilde
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

head and neck surgery
head and neck oncology
personalized diagnostics
personalized therapy
computer-assisted surgery
patient-specific implants
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Published Papers (5 papers)

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Research

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25 pages, 10560 KiB

Open AccessArticle

Exceptional Cases Demand Exceptional Personalized Solutions: The Next Level in Dental Rehabilitation

by Nils-Claudius Gellrich, Philippe Korn, Philipp Jehn, Michael Neuhaus, Fritjof Lentge and Björn Rahlf

J. Pers. Med. 2024, 14(3), 294; https://doi.org/10.3390/jpm14030294 - 9 Mar 2024

Viewed by 902

Abstract

Defects and bone loss in the maxilla and mandible pose significant challenges for dental rehabilitation. This paper focuses on complex cases of bimaxillary dental rehabilitation, where traditional dental implant protocols were not feasible in at least one jaw. Four patients were examined conceptually, where conventional dental implant placement (n = 20) was combined in either the same or opposite jaw with a patient-specific subperiosteal implant (n = 5). This study evaluates aspects such as primary stability, prosthodontic restoration, complications, and soft tissue management over the observation period. None of the five patient-specific subperiosteal implants (IPS Implants^® Preprosthetic; KLS-Martin Group, Tuttlingen, Germany) experienced failure or showed any loosening of screws, with the longest observation period extending to 68 months. These implants were securely fixated away from the posts, without any biomechanical restrictions on loading from the time of insertion. Planning and manufacturing, including the initial suprastructure, followed a fully digital workflow. The number of screws required for multivector fixation ranged from 13 to 22. All dental implants placed remain functional, definitive prosthodontic restoration has been performed, and no stability loss or peri-implantitis has been observed. The IPS Implants^® Preprosthetic emerges as a valuable consideration when conventional implant dentistry protocols encounter limitations. Full article

(This article belongs to the Special Issue Personalized Diagnostics and Therapeutics for Head and Neck Surgery)

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12 pages, 6221 KiB

Open AccessArticle

A Novel Method for Secondary Mandible Reconstruction to Re-Achieve a Native Condyle Position Comprising a New Design for Cutting Guides and New Positioning Devices

by Fritjof Lentge, Philipp Jehn, Michael-Tobias Neuhaus, Stephan A. Bettag, Nils-Claudius Gellrich and Philippe Korn

J. Pers. Med. 2024, 14(2), 181; https://doi.org/10.3390/jpm14020181 - 6 Feb 2024

Viewed by 705

Abstract

Secondary mandibular reconstruction using fibular free flaps (FFF) is a technical challenge for surgeons. Appropriate operation planning is crucial for postoperative quality control and is notably necessary for the (re-) achievement of a physiological condylar position, and the sensible expansion and shaping of the transplant. Computer-assisted planning may help to reconstruct mandibular defects in a patient-specific and precise manner. Herein, we present a newly-developed workflow for secondary mandibular reconstruction using FFF; it comprises digital planning and in-house manufacturing to perform precise secondary mandible reconstruction. This method utilizes a newly designed positioning device to ensure the precise positioning of the fibula segments in relation to each other and the mandibular stumps. The presented in-house-printed positioning device made it possible to achieve digital planning with high precision during surgery. Full article

(This article belongs to the Special Issue Personalized Diagnostics and Therapeutics for Head and Neck Surgery)

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Review

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13 pages, 268 KiB

Open AccessReview

Biologic Therapies across Nasal Polyp Subtypes

by Kody G. Bolk and Sarah K. Wise

J. Pers. Med. 2024, 14(4), 432; https://doi.org/10.3390/jpm14040432 - 19 Apr 2024

Viewed by 590

Abstract

Chronic rhinosinusitis with nasal polyposis is a common inflammatory condition, with subtypes like aspirin-exacerbated respiratory disease, allergic fungal rhinosinusitis, and central compartment atopic disease sharing a common type 2 inflammatory pathway. Respiratory biologic therapies have been developed that target type 2 inflammation. In this article, we discuss the use of respiratory biologic therapies for nasal polyposis in general, as well as within the various subtypes of nasal polyps. Further, we discuss future roles of novel biologic therapies targeting type 2 inflammation in nasal polyposis. Full article

(This article belongs to the Special Issue Personalized Diagnostics and Therapeutics for Head and Neck Surgery)

13 pages, 505 KiB

Open AccessReview

Velopharyngeal Incompetence in Musicians: A State-of-the-Art Review

by Lucía Mata-Pose, Miguel Mayo-Yáñez, Carlos M. Chiesa-Estomba, Jérôme R. Lechien, Luigi A. Vaira, Antonino Maniaci, Alberto M. Saibene, Christian Calvo-Henríquez and Irma Cabo-Varela

J. Pers. Med. 2023, 13(10), 1477; https://doi.org/10.3390/jpm13101477 - 9 Oct 2023

Viewed by 1647

Abstract

The velopalatine sphincter is a muscular valve that creates a hermetic seal between the nasopharynx and the oropharynx. It guarantees phonation, swallowing, and breathing (forces expirations). In wind musicians, sphincter closure must be precise during sound generation. Its failure will cause velopharyngeal incompetence (VPI) and the end of professional success. The objective of this article was to conduct a state-of-art review of VPI in wind musicians with a systematic approach based on the PRISMA Statement. The etiology, epidemiology, clinic, diagnosis, and treatment of VPI in wind musicians were evaluated. The research was carried out in different databases (PubMed/MEDLINE, the Cochrane Library, Scielo) and through the Mergullador metasearch engine. A total of 20 publications were selected. VPI is a pathology that affects around one-third of wind musicians according to studies. It causes pharyngeal noises and nasal air emissions during performance. The main etiology seems to be the fatigue of the velopalatine sphincter muscles. The most used diagnostic techniques consist of clinical history, physical examination, and nasofibroscopy. There is no consensus among authors about therapeutic management. Future investigations are necessary to confirm that fatigue of velopalatine sphincter muscles and other factors that increase it are the main causes of VPI in wind musicians. Full article

(This article belongs to the Special Issue Personalized Diagnostics and Therapeutics for Head and Neck Surgery)

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11 pages, 479 KiB

Open AccessReview

Indications, Efficacy, Safety, and Clinical Outcomes of 585 nm Pulsed Dye Laser in Non-Malignant Laryngeal Lesions: A Systematic Review

by Henar González-Rodríguez, Miguel Mayo-Yáñez, Alberto Maria-Saibene, Fabiana Allevi, Carlos M. Chiesa-Estomba, Luigi A. Vaira and Jerome R. Lechien

J. Pers. Med. 2023, 13(9), 1374; https://doi.org/10.3390/jpm13091374 - 14 Sep 2023

Viewed by 865

Abstract

The objective of this manuscript was to review the indications, efficacy, and safety of a 585 nm pulsed dye laser (PDL) in non-malignant laryngeal lesions. Following the PRISMA statement recommendations, three independent authors searched for articles published in PubMed/MEDLINE, the Cochrane Library, Google Scholar, Scielo, and Web of Science. A bias analysis was performed following NICE guidance tools. From the 506 identified publications, 19 observational studies met the inclusion criteria. The PDL improves vocal quality objectively and subjectively in vascular lesions (p < 0.005) and improves vocal quality in patients with dysplasia/leukoplasia without changing the natural history of the disease compared to other treatments. Reinke’s edema and granulomas require an average of 1.5 PDL sessions for resolution. Treatment of recurrent respiratory papillomatosis requires multiple sessions, with complete remission achieved in 50–70% of patients. Regardless of the lesion, the tolerance of the procedure under local anesthesia is exceptional (84–97%), and the results in terms of regression and vocal quality are promising. The complication rate is minimal, and the procedure does not interfere with other treatment alternatives. There is no consensus on laser settings. The lack of consistent use in evaluating vocal outcomes, whether objective or subjective, prevents the comparability between studies. The 585 nm pulsed dye laser appears to be an effective and safe therapeutic option in patients with non-malignant laryngeal pathology. Future controlled studies are needed to compare the 585 nm pulsed dye laser with other lasers or cold instrument procedures. Full article

(This article belongs to the Special Issue Personalized Diagnostics and Therapeutics for Head and Neck Surgery)

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